CARDIO-VENOUS DZ Flashcards

1
Q

Pt with PMH of the following: ligamentous laxity, older age, obesity, FH, standing, OCP, estrogens, trauma/surgery, smoking, DVTs or prior h/o ulcers. What are their risk?

A

Venous DZ

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2
Q

Women who have this are at high risk for benign vein abnormalities.

A

Reticular veins-Spider veins

Telangiectasis-smaller face legs

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3
Q

A vein abnormality of >3mm defines.

A

Varicose veins

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4
Q

Clinical classes of Chronic Venous Dz

A
○ 0 ​no signs of disease
○ 1​ telangiectasias or reticular veins
○ 2 ​varicose veins
○ 3​ edema
○ 4​ pigmentation or eczema
○ 5 ​healed venous ulcer
○ 6​ active venous ulcer
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5
Q

Eitology class of Chronic Venous Dz

A

○ c​ congenital-
○ p​ primary-​d/t ​valve degeneration
○ s​ secondary-post-thrombotic/trauma

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6
Q

Anatomy class of Chronic Venous Dz

A

○ s​ superficial veins
○ p​ perforator veins
○ d​ deep veins

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7
Q

Pathophysiology class of Chronic Venous Dz

A

○ r ​reflux
○ o​ obstruction
○ b= r, o​ reflux and obstruction

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8
Q

CEAP= C3EpAdPo

A

Edema
Primary degeneration
Deep vein
Obstructions

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9
Q

Pt has capillary hemangioma, limb HYPERtrophy, and varicose veins. Wha is the syndrome?

A

Klippel-Trenauany
Hallmark- PORT WINE STAIN**
Rare- congenital, dfx development of deep vein system
Unilateral

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10
Q

Which are Superficial Venous System in the Lower Extremity?

A

○ Great saphenous vein

○ small saphenous vein

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11
Q

Which Deep Veins are of Lower Extremity?

A
○ Post +Ant tibial
○ Peroneal
○ Popliteal vein/femoral
○ Profunda femoris joins femoral vein,  to become
    common femoral vein in the groin
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12
Q

What is normal ABI standing pressure?

A

90-100mmhg systolic
Calf reduces pressure by 70% w/in 10steps
Calf pumps produces 200mmhg to propel blood in one valve veins

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13
Q

How is venous HTN and ulcer developed by REFLUX?

A

leaky capillaries d/t HTN-inflam response leak into ICF
RBC, matrix metaloproteinase, destroy enzymes- affect Na/K pump= leak
More valves below the knee
Dec up to inguinal lig.
Further away from heart, need help

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14
Q

How is venous HTN and ulcer developed by OBSTRUCTion?

A

Deep vein obstruction
Pressure may NOT DEC, may INC
L/T ambulatory venous HTN + venous claudication

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15
Q

Which veins DO NOT have valves

A

common iliac, IVC/SVC, portal venus system

Less muscle to assist

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16
Q

Mrs. Myerss c/o heavy legs, fatigue, pain walking, and itching in Left calf.
PE: bulges in poplietal fossa, mild abrasions, edema, hair loss
PMH- Previous sutures for last abrasion
What other findings?

A
Venous insufficiency
Lipodermatosclerosis
Hyperpigmentation ​(​hemosiderin staining​)
Thickened nails
Varicosities
 Blistering/bullae
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17
Q

Mr. Universe has thigh pain and feeling of tightness

with exercise. What is pathology?

A

Chronic iliofemoral obstruction can result in ​venous​ ​claudication​

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18
Q

What is an inflammatory process that causes a blood clot to form and block one or more veins, and rarely l/t PE?

A

Superficial thrombophlebitis
common.
painful.
Rarely leads to PE ​b/c it’s in the superficial system

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19
Q

What is Hypoxia of subcutaneous fat lobules lead to inflammatory response?

A

Lipodermatosclerosis
**Hard “woody” induration
●Starts at ankles and progresses proximally- inveterd/ bowling pin​ appearance
● Avoid biopsy​ – ​poor healing​ of fibrotic tissue
● **
Can clinically diagnosis this!

TX- Stanozolol = anabolic steroid with fibrinolytic properties; helps with pain, inflammation and pigmentation

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20
Q

What causes hyperpigmentaion when valves fail → regurgitated blood/venous hypertension, then forces RBC’s to leak from capillaries?

A

Hemosiderin Staining-brownish-reddish discoloration
● RBC’s degrade and release iron

TX
● irreversible

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21
Q

Differiante btwn hemosiderin and cellulits?

A
  1. Hemosiderin does not extend,
  2. No calor(warm) or dolor(pain)
  3. doesn’t respond to antibiotics
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22
Q
Mrs. Myers ulcer is irregularly shaped, defined borders, erythematous, hyperpigment induration
Exudate- yellow, greenish, gray 
Her lower ankle has edema
PHM varicose veins for years
What is her DX?
A

VENOUS LEG ULCER
1/3 of lower leg MC medial mallelous (Gaiter old term)
RARE above knee or on foot

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23
Q

What is presentation of Venous Leg ULcers that interesting?

A

Look bad BUT PAINLESS

TX- R.i.C.E, Diuretics prn

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24
Q

How do you treat VENOUS LEG Ulcer ?

A

IF ulcer- compression unnas and profore
ASA
ABX if infected and Dress

IF NO ulcer
Elevation
Check ABI and pulse
Compression Therapy- if NORMAL ABI**. Circaid, Stockings

25
What is name of ulcer if round, punch hole, painful, but relieve with walking, at tip of toes, on foot?
Arterial Ulcers
26
What should be checked prior to compression for venous ulcers?
***​pedal pulses,​ ​femoral +popliteal pulses ● Get an ​ABI in office ○ If ABI < 0.70 → refer
27
What are other causes of venous and arterial ulcers?
``` Untreated CHF - lung rales Lymphedema - S/P surgery Arterial disease Cellulitis DVT Squamous cell carcinoma ​of skin- *MARJOLIN ULCER ```
28
How is Ankle Bracial Index determined
``` RABI= R ankle/R arm BP divided by LABI= L ankle/L arm BP Normal= 1.00-1.29 <0.70 =refer <0.20= arterial dz ```
29
What is gold standard lab test to determine damage of central veins?
Rare for VLU CT MR venography
30
Which lab test MC orderded, inexpensive, reliable and confirms reflux?
Duplex US-MC
31
MS MYERS US is normal. What are the other DDX?
``` ○Arterial Dz** ○Lymphedema ○ Rheumatoid ulcer ○ Sickle Cell ulcer ○ Marjolin’s ulcer-SCC ```
32
Mrs. Myers skin W/ active ulcer is a venous DISEASE. What is initial tX?
**Compression​ to reduce venous hypertension Profore and Unna's boot-for ULCERS active Elevate Walking- stop if pain, then repeat DEC wt DEC standing/sit Skin checks-MOISTure
33
What is drug is used to heal treat venous insufficiency?
Simvastatin- EMB B, not effective
34
After 2 weeks Mrs. Meyers is back with an abrasion that is not healing? what is next step
Control exudate Debride- no sharps VENEFIT- endovenous radio-frequency ablation RFA catheter to collapse/close veins
35
What is RX to improve ulcer healing?
Pentoxifyline- rare in wound care
36
Mrs. Myers ulcer smells and is green. What is next step?
Culture d/t signs of infections Pseudomonas -green E. coli norma flora PT education- lots of soap and water
37
Mrs. Stockings is here with claudication, edema, hyperpigmentation. What is contraindicated b4 compression therapy?
○ Arterial disease- pulses/obtain ABI ○ CHF- treat 1st ○ Neuropathy- CIRCAIDS only ○ Active cellulitis- treat 1st
38
What is needed to reassure Mrs. Stockings?
``` VLU are NOT life or limb threatening ■ blood flow is sufficient ■ Caution infected/sepsis HCP- ALWAYS measure size 60-70% closed 3-6mo ``` If not response- vascular surgeon, misdiagnosed Arterial dz- get doppler/ABI Vasculitis, Marjoin- biopsy
39
What should NEVER be used for compression?
**ACE wraps- harm IDEAL 20-30mmhg- Profore, Circaids, Unna boot Graduated stockings Measure- thick calf or thigh part Weekly dressing change d/o exudate
40
What can be used once the person has a healed ulcer?
Circaids- continued compression | Compression stockings
41
What is rare congenital syndrome that Compresses left common iliac vein by the right common iliac artery?
May-Thurner 20% +/- SX- edema, leg ASYM, thrombosis TX- stent referral
42
Pt has stasis, hypercoagulate state, with vein injury 2/2 surgery for breast cancer. What is the triad and risk?
Virchow's triad | Risk-Thromboembolism
43
Ms. Vain has c/c pain, warmth, redness, tight cord in her varicose veins? What is on DDX
Phlebitis- inflammation of veins, not life threatening, self limiting 2-4wks. F/u 7-10d WU-#1 US and/or D-dimer (lab) 99% neg predictive value TX- topical Diclofenac/NSAIDs, ICE
44
Mr. T has c/c pain, warmth, redness, tight cord in his leg P/O varicose vein removal?What is DDX
Thrombosis- clot, deep or superficial
45
What is special test for DVT/SVT when passive flex w/ squeeze calf?
Homan sign-NOT good SP/SN | **US highly sensitive in femor/pop vs calf
46
US confirmed Mr. T's thrombosis w/ >5cm and <5cm from the deep system. What is next Tx?
DVT High risk pt-Warfarin-anticoagulation therapy​ ​4 weeks​. SVT- supportive confirmed US
47
Mr T has UL pitting edema, local tenderness, and in bed 3days. What is his Wells score
Well Clinical Prediction Rule for DVT ● >3 = high probability of DVT ● 1-2 = moderate probability of DVT ● 0 = low probability of DVT
48
Mr. T D-Dimer labs returned positive what is next step with low Wells score of 0?
US if neg- NO DVT IF post- TREAT
49
Mrs. Meyers well score is 3, What is next for work up?
US- 1st before d-dimer IF NEG- D-dimer IF POST- DVT
50
Tim post op ACL has massive swelling in leg blue in color. What is DDX
``` DVT-EMERGENT Phlegmasia Cerulea Dolens ● collateral veins -HUGE thrombosis! ● Increased​ congestion ● Affects arterial flow ​→ ​ischemia ● Risk of ​gangrene TX- surgery ```
51
Jen is 12 wks postpartum with massive swelling in her pale L leg, coming back from vacation in Spain. What is DX?
``` DVT URGENT Phlegmasia Alba Dolens ● NO collateral veins- ● Less​ venous congestion ● No​ ischemia ● Higher-in ​3rd trimester​ and ​postpartum ```
52
Anticoagulation goal is to ​prevent the propagation​ of thrombus or embolism to the pulmonary circulation. What does it NOT do?
NOT dissolve clot​ but allows the fibrinolytic system to eliminate it over time.
53
What are risk with DVT over time?
Postphlebitic syndrome Leg discomfort and edema 1-2y after DVT ● 80% w/ DVT- develop venous insufficiency signs after 5-10 years.
54
Ms. Myers has a distal DVT, stable, no renal dz, low bleeder. What are next TX steps?
1st send to surgery IVC filter- chops clot Then TX LTC Can she safely administer LMWH-low molecular wt heparin at home LMWH- inj BID until INR PT range is 2-3 IF so...give 5mg warfarin PO QD 1st DVT unprovoked- min 3 mo of LMWH 1st DVT d/t surgery min 3mo REcurrent- 6-12 mo High Risk recurrent DVT- LTC
55
When people have a Iliofemoral DVT, a PE , or co-morbiites, and high risk bleeder? Then where to they go
ADMIT ED | HIGH Risk of Pulmonary embolism
56
Who are at risk for hypercoagulabiltiy?
``` maligancy pregnacny oestrogen tx trauma, surgery waist- toes IBD nephrotic syndrome Sepis Thrombophilia ```
57
Who are at risk for vascular wall injury?
``` Trauma surgery venepuncture chemical irriation heart valve dz athersclerosis Indwelling catheters ```
58
Who are the circulatory stasis people?
``` A. fib LV dysfx Immobile Venous insuff, varicose veins venous obstruction tumor obesity preg. ```
59
Who should NEVER have anticoagulation TX?
``` ● Active bleeding ● Severe bleeding diathesis/​tendency ● Platelet count <50,000/microL ● Recent, planned, or emergent surgery/procedure ● Major trauma ● H/o intracranial hemorrhage ● H/o heparin-induced thrombocytopenia ```