CARDIO-HTN* Flashcards

1
Q

Who are at risk for HTN

A
**POSTmenopause
Blacks 
60+ 
M, W- 23%
White/Hispanic, 40+
Obese
PMH CVD
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2
Q

What is the MC reason for medical office visits and prescription drugs in the US?

A

HTN
1:4 Americans
31% unaware-silent killer

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3
Q

What does the USPSTF recommend BP screening adults?

A

starting at 18
○ Annual >40 years
○ Annual high risk patients
○ 3-5 years for normotensive, avg risk patients
○ BP readings outside clinical setting for diagnostic confirmation, treatment
PEDs- BP at 2y, then 1-3-5yr FH

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4
Q

Pts >60yo: BP<152/95. Did this person meet goal of HTN?

A

NO. 2017
Pts <65yo: GOAL is <130/80;

Pts >65yo w comorbid: GOAL <150/90

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5
Q

PT has BP of 132/90 at first visit, what is diagnosis?

A

ALWAYS NEED 2+ ​ properly measured readings

​AT 2+ visits after an initial screen​

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6
Q

Pt has a BP of 128/80 at 2 visits? What is the diagnosis?

A

Elevated​:
○ systolic 120-129
diastolic <80

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7
Q

Pt has a BP of 135/88 at 2 visits? What is the diagnosis?

A

HTN STAGE 1
● Hypertension​:
○ Stage 1: systolic 130-139 or diastolic 80-89
○ Stage 2: systolic ≥140 or diastolic ≥90 or higher

USPSTF- 2017 ABPM- one criteria of ABPM can DX HTN

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8
Q

What is the pathphysicology of blacks risk for HTN?

A

poorly understood:

AA lower renin levels L/T ACEI not useful in AA’s

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9
Q

What system will make a pt more sensitive to stress?

A

INC SNS

enhanced beta-adrenergic responsiveness-sensitive to stress and fight-or-flight response

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10
Q

How do the kidneys contribute to HTN?

A

○INC HR (via stretch of atria w/BV)_DEC LV contraction rate/DEC CO, stimulate RAAS

INC angiotensin vasoconstriction, SNS

Reduced adult nephron size - smaller so can’t filter as well → low filtrate L/T activated RAAS

Aldosterone-INC NA channels for resorption and H20 retention, lowers K

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11
Q

What genetics and neonatal factors play are role HTN?

A

■ intrauterine neonatal risk HTN: hypoxia, drugs, nutritional deficiency​, smoking mom
■ malnutrition, infections

○ Genetic:2 HTN parents=2x risk

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12
Q

What is the main cause of secondary HTN?

A

Renal artery stenosis*- 10%

consider of HTN resistant if Pt on multi meds

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13
Q

What questions should you ask for HTN?

A

STOP BANG- Snore, Tired, Observed, Pressure, BMI, Age, Neck cir, Gender M.
HTN 2/2 OSA
Screen OSA pt

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14
Q

What happens if mechanical obstruction in Aorta?

A

Coarctation of the Aorta
SECONDARY HTN
DEC flow is responsible for the elevation of BP in the upper extremities vs lower

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15
Q

How is the endocrine system connected with HTN?

A

● Pheochromocytoma- Catecholamine-secreting tumors​

● Primary hyperaldosteronism- HTN BP is dependent on mild volume expansion that occurs

● Cushing’s syndrome ​d/t elevated cortisol

● Ectopic ACTH — Severe hypertension and hypokalemia

● Hyper/Hypothyroidism

● Hyperparathyroidism

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16
Q

What suggestions are needed for blacks in risk of HTN?

A

●MC and severe
● ​higher sodium intake leads to higher BP
● Excess​ alcohol intake
● Smoking ​(ruins endothelium)
● Obesity and sedentary lifestyle
● Dyslipidemia
● Personality traits / Stress – hostile, anxious, type A

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17
Q

Pt is 25 and here for annual PE, what can be used for CVD risk?

A
app ASCVD risk calculator- use Q 4-6yr Pt 20-79
age
gender
race
lipids
BP
DM
smoking
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18
Q

Why is HTN treated so aggressively early?

A
**complications Small vessel damage**GOAL prevent End organ dz.
CHF
LVH-ventricular arrhythmia
MI
ESRD renal-check microalbumin, SCr/yr
stroke
Retinopathy- HTN MC
PV- ask ED pain walking, intermittent claudication
Emergency
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19
Q

What should be included on all HTN cases?

A

Mini Mental/MOCA - r/o HTN complication in brain

Risk of CVA or intracranial HTN

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20
Q

How do you work up HTN?

A

**BMP- Chem 7- Na, K, BUN, Scr, Cl/HCO3, Glucose
CBC-WBC, Hgb, Ht (thick), bands, MCV +-
Fasting lipids- TGs (high), LDL(high), HDL (low not good)
UA- microalbuminuria DM
ECG- LVH, arrhythmias, MIs (q-wave, STEMI, inverted T-wave). Q2y
ROS- TSH, toxicology

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21
Q

What lifestyle modification will manage HTN?

A
whole foods
<200mg Na/ day
INC K+- aldosterone factor- watch toxic
Exercise
Wt loss- 10kg (22 loss= 5-20 reduction in BP
Stress control
Dec. Alcohol
NO smoke
Risk for DM-screen
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22
Q

Pt 45y smoker obese has > 6-7% risk with 10yr calculator? What should they take?

A

Statin therapy- not for everyone, Atorvastatin
ADE- monitor LFT, lipid

or has: pre/DM and high LDL/low HDL/ high cholesterol, metabolic syndrome,
ASA aspirin 81mg
Check DM

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23
Q

What should you include in PE for HTN risk pt?

A
vitals
EYES-retinopathy: flame, cotton, exudates 
Brain-CN, HA
Neck- bruits, thyroid
Heart- PMI displaced, Arrythimia, Murmurs, thrills, lifts
Lungs- Basal crackles/rales
ABD- pulses, width AAA, bruits, acite
PV- pules, cap, pitting edema, lesions
M- Erectile Dys
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24
Q

Mr. Pressure, 55 years, BP 145/85. What is the biggest concern?

A

SBP > 140 mmHg higher CVD risk factor than DBP.
● risk of CVD doubles with each increment over 20/+10 mmHg
● normotensive at 55y have a 90% lifetime risk for developing HTN

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25
Q

Persons has DM and CKD, BP is 132/85. What is there goal BP and TX?

A
2017
Goal <130/80
Stage 1 HTN-LIFESTYLE and RX
NO CVD risk-Lifestyle changes, DASH diet, limit salt, ETOH, fats, 
Wt loss
RX-ACE

Reassess- 1mo
IF at goal Reassess- 3-6mo

26
Q
What are the avg BP reduction for the following lifestyle changes
WT loss
DASH plan
NA reduction
Activity
Dec Alcohol
A
WT loss- 10kg loss- 5-20mm/hg
DASH plan- 8-14
NA reduction- 2-8
Activity- 4-9
Dec Alcohol- 2-4
27
Q

Which medication should be avoided in HFreducedEF.
Thiazide diuretic
Beta Blocker
Calcium channel blocker
Angiotensinigen convert enzyme inhib- ACEI
Angiotensin receptor blocker-ARB
Aldosterone antagonist-Aldo ANT

A

AVOID CCB in HF reduced EF- systolic

28
Q

Which medication should a ischemia Heart Dx pt initially start?

A

MI- BB, ACEI
Angina-BB, CCB

ADD CCB or Thiazide

CVA- Thiazide diuretic, ACEI

29
Q

What medication should a High CVD risk pt initially start

A

Thiazide diuretic- Thiaz
BB
Angiotensin convert enzyme inhib- ACEI
Calcium channel blocker- inc CA inc inflam/contract

30
Q

What medication should a DM pt initially start

A

ACEI w/ albuminuria**- renal protective
Calcium channel blocker
Angiotensin receptor blocker-ARB
Thiazide diuretic- LAST resort

31
Q

What medication should a CKD pt initially start

A

ACEI

ARB

32
Q
Which medication should NOT be used in HFpreservedEF 
Chlorthalidone
CCB
Nitrates
A-blockers
A

**AVOID CCB, nitrates, a-blockers

HFpreservedEF- diastolic- Cholorthalidone

33
Q

At what BP is medication required for people <60?

A
STAGE 1 HTN>130-139/80-89 w/ cormorbid
Lifestyle modification
DOC #1-Thiazide diuretic
Beta Blocker
ACEI
ARB
34
Q

At what BP is 2 medication required for people?

A

STAGE 2-SBP >140/90
therapy with ​two agents at the same time ​=more side effects

Thiazide diuretic + 1 below

Beta Blocker 
ACEI
ARB
Aldo ANT
CBB- calcium inc rxn/inflam
35
Q

What is metabolic syndrome?

A

Waist circumference ≥40 inches men, ≥35 inches women

DYSLIPIDEMIA
Serum TG ≥ 150 mg/dL
Serum HDL <40 mg/dL men, <50 mg/dL women

○ BP ≥130/85 mmHg

○HYPERGLYCEMIA- FPG ≥100, IGT >140, >200, A1C 5.7->6.49, RPG >200

36
Q

What are 3-6 month goals for HTN w/ metabolic syndrome?

A

○ Goal BP <120/80 ​(at least <130/80)
○ Goal FPG <100
○ Goal TG <150, HDL >40, LDL <130

37
Q

What is difference for black with first line for STAGE 1-2

A

Thiazide diuretic
Calcium channel blocker

AVOID- ACEI/ARB

38
Q

What is difference for CKD with first line for STAGE 1-2

A

Initial or add-on tx
ACEI OR ARB
NEVER BOTH

39
Q

What are goals of antihypertensive meds?

A

PRIMARY LOWER SBP- DBP will follow

dec CV and ERSD

40
Q

Pt is 30y w/ DBP of 92. What is next step

A
HTN STAGE 2
RX
Lifestyle modification
DOC #1
Thiazide diuretic
Beta Blocker
ACEI
ARB
41
Q

PT has CAD, Which RX provides better CV protection in?

A

Thiazide Diuretic- inc Na and H2O excretion
Oldest/studied
ADE- urinary frequency, hypokalemia, hyperglycemia
HCTZ, chorothalizone

***unlikely ACE or CCB

42
Q

What is the method of titrating with combo therapy?

A

○ Start 1 drug, titrate to max dose, then add 2nd drug
LOW and SLOW
If BP goal is >20 SBP/ >10DB to reduce, or HIGH, Start 2 drug slow and low

43
Q

What if PT is relatively unresponsive to one drug?

A

50% likely to be normotensive w/ a different drug
**● If ​NO​ response 1st- ​switch​ rather than add 2nd

○ 70-80% mild hypertension will be controlled with a single agent

● Most require more than one medication!***

44
Q

What RX block the formation of angiotensin II?

A

ACE Inhibitors
○ Arterial dilation, dec. resistance to blood flow and consequently dec. blood pressure
● First-line: ​heart failure​ or ​asymptomatic LV dysfunction, MI, anterior infarct, DM, systolic dysfunction, proteinuric chronic kidney disease​
-DOC for DM/CKD

● ADE- 10% ​chronic nonproductive cough lungs conversion- d/c the ACE inhibitor!
○ Angioedema​: Rare, ​(life-threatening)
○ May affect renal function and raise the potassium level

■ Check Chem 7 - 1 week after initiating ACEI therapy
■ Consult a nephrologist patient with known renal disease

45
Q

What RX blocks binding of angiotensin II to the AT1 receptor?

A

Angiotensin Receptor Blocker
● Similar to ACE inhibitors
● For pts who do not tolerate ACE inhibitors
● Improve CHF symptoms, decrease hospitalizations for heart failure, and decreased morbidity
● Now generics are available

46
Q

Can pregnant woman take ACE or ARBs?

A

NO!

47
Q

What RX decrease force of contraction and dialate peripherally and COPD pt may benefit?

A

Calcium Channel Blockers
● Decrease BP by decreasing the force of myocardial contractions, dilating the arteries, decreasing resistance to blood flow

● ADEs
○ ​worsen CHF symptoms
○ Verapamil - ​constipation​, elderly
○ Headache and LE​ ​edema

48
Q

Which drug combo should be avoided?

A
  1. **diuretic with CCB-hypotensive risk

2. ACEI with β-blocker- hypotensive

49
Q

What are better combo choices?

A

1- ACEI + diuretic,
2- ACEI + CCB
BLACKS Diuretic +BB

50
Q

Which two drugs in combo may lead to bradycardia​ or heart block?

A

Beta blocker and CCB

NEVER USE SAME MOA OF RX

51
Q

Why may some ACE inhibitor not work on AA or elderly?

A

Lower plasma renin activity- PRA

Whites - higher PRA

52
Q

What drug is not a TRUE indicator of hypertension?

A

Beta blockers

Need another DX- post MI, HF, Afib, CAD/Agina

53
Q

What is severe HTN in ASX pt?

A

HYPERTENSION URGENCY
SBP ≥180 mmHg
DBP ≥120 mmHg

TX- DO NOT RAPID BP REDUCTION d/t risk of stroke
GOAL- DEC hrs/days w/ ORALS
MONITOR 1-2hr OUTPATIENT before going home

54
Q

Pt has BP 180/122 with retinal hemorrhages, exudates, papilledema. What is next step

A
ER-ACUTE HTN EMERGENCY
CP
1-HTN ENCEPHALOPATHY-seizure, mental altered, HA+, VA s/s
2. Oliguria- ARF
3. Eclampsia- pregnant/post
55
Q

What do we manage 1st? DM or BP

A

1 BP first/under control 2. DM

56
Q

What are the leading cause of ARF, stroke, CAD and CVA?

A

DM and HTN
● HTN is the leading cause of stroke
● CAD and CVA are the leading causes of death in women ​(esp >55yo) ​over all other causes combined

57
Q

What is ideal agents for elderly?

A

​CCB, diuretics -less likely to have orthostatic hypotension

***AVOID-Beta blocker, ACEI

58
Q

What are agents for CVD?

A

● CHF:​ ACEI/ARB, diuretic, BB-caution

● Post-MI:​ beta blocker, ACEI/ARB, aldosterone antagonist

● Angina: ​BB, CCB (women)

● Afib/flutter: ​BB, non-DHP CCB (eg, Verapamil

PVCs/PACs: ​beta blocker

59
Q

What are renal protective?

A

CKD: ​ACEI/ARB

60
Q

What are other hypertensives useful for?

A

● BPH:​ alpha blocker (works on peripheral vasculature → causes vasodilation)
● Tremor:​ beta blocker
● Hyperthyroid:​ beta blocker (for tachycardia)
● Migraine:​ beta blocker, CCB

61
Q

What contraindications are for Beta blockers?

A

○ Asthma/COPD/bronchospasms → NO beta blocker
○ Heart block → NO beta blockers or non-DHP CCB
○ Depression → beta blockers
○ Elderly!

62
Q

Avoid diuretics for the following?

A
○ Hypokalemia → NO diuretics (thiazide/loop)
○ Hypomagnesemia → NO diuretics
○ Hypocalcemia → NO loop
○ Hyperlipidemia → NO diuretics
○ Hyperglycemia → NO diuretics
○ Hypercalcemia →NO thiazides