CARDIO-HTN* Flashcards

1
Q

Who are at risk for HTN

A
**POSTmenopause
Blacks 
60+ 
M, W- 23%
White/Hispanic, 40+
Obese
PMH CVD
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2
Q

What is the MC reason for medical office visits and prescription drugs in the US?

A

HTN
1:4 Americans
31% unaware-silent killer

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3
Q

What does the USPSTF recommend BP screening adults?

A

starting at 18
○ Annual >40 years
○ Annual high risk patients
○ 3-5 years for normotensive, avg risk patients
○ BP readings outside clinical setting for diagnostic confirmation, treatment
PEDs- BP at 2y, then 1-3-5yr FH

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4
Q

Pts >60yo: BP<152/95. Did this person meet goal of HTN?

A

NO. 2017
Pts <65yo: GOAL is <130/80;

Pts >65yo w comorbid: GOAL <150/90

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5
Q

PT has BP of 132/90 at first visit, what is diagnosis?

A

ALWAYS NEED 2+ ​ properly measured readings

​AT 2+ visits after an initial screen​

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6
Q

Pt has a BP of 128/80 at 2 visits? What is the diagnosis?

A

Elevated​:
○ systolic 120-129
diastolic <80

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7
Q

Pt has a BP of 135/88 at 2 visits? What is the diagnosis?

A

HTN STAGE 1
● Hypertension​:
○ Stage 1: systolic 130-139 or diastolic 80-89
○ Stage 2: systolic ≥140 or diastolic ≥90 or higher

USPSTF- 2017 ABPM- one criteria of ABPM can DX HTN

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8
Q

What is the pathphysicology of blacks risk for HTN?

A

poorly understood:

AA lower renin levels L/T ACEI not useful in AA’s

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9
Q

What system will make a pt more sensitive to stress?

A

INC SNS

enhanced beta-adrenergic responsiveness-sensitive to stress and fight-or-flight response

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10
Q

How do the kidneys contribute to HTN?

A

○INC HR (via stretch of atria w/BV)_DEC LV contraction rate/DEC CO, stimulate RAAS

INC angiotensin vasoconstriction, SNS

Reduced adult nephron size - smaller so can’t filter as well → low filtrate L/T activated RAAS

Aldosterone-INC NA channels for resorption and H20 retention, lowers K

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11
Q

What genetics and neonatal factors play are role HTN?

A

■ intrauterine neonatal risk HTN: hypoxia, drugs, nutritional deficiency​, smoking mom
■ malnutrition, infections

○ Genetic:2 HTN parents=2x risk

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12
Q

What is the main cause of secondary HTN?

A

Renal artery stenosis*- 10%

consider of HTN resistant if Pt on multi meds

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13
Q

What questions should you ask for HTN?

A

STOP BANG- Snore, Tired, Observed, Pressure, BMI, Age, Neck cir, Gender M.
HTN 2/2 OSA
Screen OSA pt

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14
Q

What happens if mechanical obstruction in Aorta?

A

Coarctation of the Aorta
SECONDARY HTN
DEC flow is responsible for the elevation of BP in the upper extremities vs lower

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15
Q

How is the endocrine system connected with HTN?

A

● Pheochromocytoma- Catecholamine-secreting tumors​

● Primary hyperaldosteronism- HTN BP is dependent on mild volume expansion that occurs

● Cushing’s syndrome ​d/t elevated cortisol

● Ectopic ACTH — Severe hypertension and hypokalemia

● Hyper/Hypothyroidism

● Hyperparathyroidism

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16
Q

What suggestions are needed for blacks in risk of HTN?

A

●MC and severe
● ​higher sodium intake leads to higher BP
● Excess​ alcohol intake
● Smoking ​(ruins endothelium)
● Obesity and sedentary lifestyle
● Dyslipidemia
● Personality traits / Stress – hostile, anxious, type A

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17
Q

Pt is 25 and here for annual PE, what can be used for CVD risk?

A
app ASCVD risk calculator- use Q 4-6yr Pt 20-79
age
gender
race
lipids
BP
DM
smoking
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18
Q

Why is HTN treated so aggressively early?

A
**complications Small vessel damage**GOAL prevent End organ dz.
CHF
LVH-ventricular arrhythmia
MI
ESRD renal-check microalbumin, SCr/yr
stroke
Retinopathy- HTN MC
PV- ask ED pain walking, intermittent claudication
Emergency
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19
Q

What should be included on all HTN cases?

A

Mini Mental/MOCA - r/o HTN complication in brain

Risk of CVA or intracranial HTN

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20
Q

How do you work up HTN?

A

**BMP- Chem 7- Na, K, BUN, Scr, Cl/HCO3, Glucose
CBC-WBC, Hgb, Ht (thick), bands, MCV +-
Fasting lipids- TGs (high), LDL(high), HDL (low not good)
UA- microalbuminuria DM
ECG- LVH, arrhythmias, MIs (q-wave, STEMI, inverted T-wave). Q2y
ROS- TSH, toxicology

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21
Q

What lifestyle modification will manage HTN?

A
whole foods
<200mg Na/ day
INC K+- aldosterone factor- watch toxic
Exercise
Wt loss- 10kg (22 loss= 5-20 reduction in BP
Stress control
Dec. Alcohol
NO smoke
Risk for DM-screen
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22
Q

Pt 45y smoker obese has > 6-7% risk with 10yr calculator? What should they take?

A

Statin therapy- not for everyone, Atorvastatin
ADE- monitor LFT, lipid

or has: pre/DM and high LDL/low HDL/ high cholesterol, metabolic syndrome,
ASA aspirin 81mg
Check DM

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23
Q

What should you include in PE for HTN risk pt?

A
vitals
EYES-retinopathy: flame, cotton, exudates 
Brain-CN, HA
Neck- bruits, thyroid
Heart- PMI displaced, Arrythimia, Murmurs, thrills, lifts
Lungs- Basal crackles/rales
ABD- pulses, width AAA, bruits, acite
PV- pules, cap, pitting edema, lesions
M- Erectile Dys
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24
Q

Mr. Pressure, 55 years, BP 145/85. What is the biggest concern?

A

SBP > 140 mmHg higher CVD risk factor than DBP.
● risk of CVD doubles with each increment over 20/+10 mmHg
● normotensive at 55y have a 90% lifetime risk for developing HTN

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25
Persons has DM and CKD, BP is 132/85. What is there goal BP and TX?
``` 2017 Goal <130/80 Stage 1 HTN-LIFESTYLE and RX NO CVD risk-Lifestyle changes, DASH diet, limit salt, ETOH, fats, Wt loss RX-ACE ``` Reassess- 1mo IF at goal Reassess- 3-6mo
26
``` What are the avg BP reduction for the following lifestyle changes WT loss DASH plan NA reduction Activity Dec Alcohol ```
``` WT loss- 10kg loss- 5-20mm/hg DASH plan- 8-14 NA reduction- 2-8 Activity- 4-9 Dec Alcohol- 2-4 ```
27
Which medication should be avoided in HFreducedEF. Thiazide diuretic Beta Blocker Calcium channel blocker Angiotensinigen convert enzyme inhib- ACEI Angiotensin receptor blocker-ARB Aldosterone antagonist-Aldo ANT
**AVOID CCB** in HF reduced EF- systolic
28
Which medication should a ischemia Heart Dx pt initially start?
MI- BB, ACEI Angina-BB, CCB ADD CCB or Thiazide CVA- Thiazide diuretic, ACEI
29
What medication should a High CVD risk pt initially start
Thiazide diuretic- Thiaz BB Angiotensin convert enzyme inhib- ACEI Calcium channel blocker- inc CA inc inflam/contract
30
What medication should a DM pt initially start
ACEI w/ albuminuria**- renal protective Calcium channel blocker Angiotensin receptor blocker-ARB Thiazide diuretic- LAST resort
31
What medication should a CKD pt initially start
ACEI | ARB
32
``` Which medication should NOT be used in HFpreservedEF Chlorthalidone CCB Nitrates A-blockers ```
**AVOID CCB, nitrates, a-blockers | HFpreservedEF- diastolic- Cholorthalidone
33
At what BP is medication required for people <60?
``` STAGE 1 HTN>130-139/80-89 w/ cormorbid Lifestyle modification DOC #1-Thiazide diuretic Beta Blocker ACEI ARB ```
34
At what BP is 2 medication required for people?
STAGE 2-SBP >140/90 therapy with ​two agents at the same time ​=more side effects Thiazide diuretic + 1 below ``` Beta Blocker ACEI ARB Aldo ANT CBB- calcium inc rxn/inflam ```
35
What is metabolic syndrome?
Waist circumference ≥40 inches men, ≥35 inches women DYSLIPIDEMIA Serum TG ≥ 150 mg/dL Serum HDL <40 mg/dL men, <50 mg/dL women ○ BP ≥130/85 mmHg ○HYPERGLYCEMIA- FPG ≥100, IGT >140, >200, A1C 5.7->6.49, RPG >200
36
What are 3-6 month goals for HTN w/ metabolic syndrome?
○ Goal BP <120/80 ​(at least <130/80) ○ Goal FPG <100 ○ Goal TG <150, HDL >40, LDL <130
37
What is difference for black with first line for STAGE 1-2
Thiazide diuretic Calcium channel blocker AVOID- ACEI/ARB
38
What is difference for CKD with first line for STAGE 1-2
Initial or add-on tx ACEI OR ARB NEVER BOTH
39
What are goals of antihypertensive meds?
PRIMARY LOWER SBP- DBP will follow | dec CV and ERSD
40
Pt is 30y w/ DBP of 92. What is next step
``` HTN STAGE 2 RX Lifestyle modification DOC #1 Thiazide diuretic Beta Blocker ACEI ARB ```
41
PT has CAD, Which RX provides better CV protection in?
Thiazide Diuretic- inc Na and H2O excretion Oldest/studied ADE- urinary frequency, hypokalemia, hyperglycemia HCTZ, chorothalizone ***unlikely ACE or CCB
42
What is the method of titrating with combo therapy?
○ Start 1 drug, titrate to max dose, then add 2nd drug LOW and SLOW If BP goal is >20 SBP/ >10DB to reduce, or HIGH, Start 2 drug slow and low
43
What if PT is relatively unresponsive to one drug?
50% likely to be normotensive w/ a different drug **● If ​NO​ response 1st- ​switch​ rather than add 2nd ○ 70-80% mild hypertension will be controlled with a single agent ● Most require more than one medication!***
44
What RX block the formation of angiotensin II?
ACE Inhibitors ○ Arterial dilation, dec. resistance to blood flow and consequently dec. blood pressure ● First-line: ​heart failure​ or ​asymptomatic LV dysfunction, MI, anterior infarct, DM, systolic dysfunction, proteinuric chronic kidney disease​ -DOC for DM/CKD ● ADE- 10% ​chronic nonproductive cough lungs conversion- d/c the ACE inhibitor! ○ Angioedema​: Rare, ​(life-threatening) ○ May affect renal function and raise the potassium level ■ Check Chem 7 - 1 week after initiating ACEI therapy ■ Consult a nephrologist patient with known renal disease
45
What RX blocks binding of angiotensin II to the AT1 receptor?
Angiotensin Receptor Blocker ● Similar to ACE inhibitors ● For pts who do not tolerate ACE inhibitors ● Improve CHF symptoms, decrease hospitalizations for heart failure, and decreased morbidity ● Now generics are available
46
Can pregnant woman take ACE or ARBs?
NO!
47
What RX decrease force of contraction and dialate peripherally and COPD pt may benefit?
Calcium Channel Blockers ● Decrease BP by decreasing the force of myocardial contractions, dilating the arteries, decreasing resistance to blood flow ● ADEs ○ ​worsen CHF symptoms ○ Verapamil - ​constipation​, elderly ○ Headache and LE​ ​edema
48
Which drug combo should be avoided?
1. **diuretic with CCB-hypotensive risk | 2. ACEI with β-blocker- hypotensive
49
What are better combo choices?
1- ACEI + diuretic, 2- ACEI + CCB BLACKS Diuretic +BB
50
Which two drugs in combo may lead to bradycardia​ or heart block?
Beta blocker and CCB | NEVER USE SAME MOA OF RX
51
Why may some ACE inhibitor not work on AA or elderly?
Lower plasma renin activity- PRA | Whites - higher PRA
52
What drug is not a TRUE indicator of hypertension?
Beta blockers | Need another DX- post MI, HF, Afib, CAD/Agina
53
What is severe HTN in ASX pt?
HYPERTENSION URGENCY SBP ≥180 mmHg DBP ≥120 mmHg TX- DO NOT RAPID BP REDUCTION d/t risk of stroke GOAL- DEC hrs/days w/ ORALS MONITOR 1-2hr OUTPATIENT before going home
54
Pt has BP 180/122 with retinal hemorrhages, exudates, papilledema. What is next step
``` ER-ACUTE HTN EMERGENCY CP 1-HTN ENCEPHALOPATHY-seizure, mental altered, HA+, VA s/s 2. Oliguria- ARF 3. Eclampsia- pregnant/post ```
55
What do we manage 1st? DM or BP
#1 BP first/under control 2. DM
56
What are the leading cause of ARF, stroke, CAD and CVA?
DM and HTN ● HTN is the leading cause of stroke ● CAD and CVA are the leading causes of death in women ​(esp >55yo) ​over all other causes combined
57
What is ideal agents for elderly?
​CCB, diuretics -less likely to have orthostatic hypotension ***AVOID-Beta blocker, ACEI
58
What are agents for CVD?
● CHF:​ ACEI/ARB, diuretic, BB-caution ● Post-MI:​ beta blocker, ACEI/ARB, aldosterone antagonist ● Angina: ​BB, CCB (women) ● Afib/flutter: ​BB, non-DHP CCB (eg, Verapamil PVCs/PACs: ​beta blocker
59
What are renal protective?
CKD: ​ACEI/ARB
60
What are other hypertensives useful for?
● BPH:​ alpha blocker (works on peripheral vasculature → causes vasodilation) ● Tremor:​ beta blocker ● Hyperthyroid:​ beta blocker (for tachycardia) ● Migraine:​ beta blocker, CCB
61
What contraindications are for Beta blockers?
○ Asthma/COPD/bronchospasms → NO beta blocker ○ Heart block → NO beta blockers or non-DHP CCB ○ Depression → beta blockers ○ Elderly!
62
Avoid diuretics for the following?
``` ○ Hypokalemia → NO diuretics (thiazide/loop) ○ Hypomagnesemia → NO diuretics ○ Hypocalcemia → NO loop ○ Hyperlipidemia → NO diuretics ○ Hyperglycemia → NO diuretics ○ Hypercalcemia →NO thiazides ```