Cardio Physiology Part 1 Flashcards
What are the three principal components of the cardiovascular system?
- Heart
- Blood Vessels
- Blood
What are the formed elements in blood?
- Red Blood Cells
- Platelets
- White Blood Cells
What are the two divisions in White Blood Cells or leukocytes?
- Granulocytes
- Agranulocytes
What are the three types of granulocytes?
- Neutrophils
- Eosinophils
- Basophils
What are the two types of agranulocytes?
- Lymphocyte
- Monocyte
This carries blood cells, proteins, nutrients, metabolic wastes, and other molecules transported around the body
Plasma
This is a physiological mechanism that stops bleeding
Hemostasis
What is the 3-step process of hemostasis?
- Vascular spasm
- Platelet plug formation
- Blood coagulation
This results from damage to the blood vessel. The damaged tissue secretes factors that cause contraction.
Vascular spasm
Vessels __________ to minimize blood loss
Constrict
This forms around the site of damage to decrease blood loss and maintain blood pressure.
Platelet Plug Formation
This occurs around the platelet plug, providing protection or blood clots.
Blood coagulation
These are secreted in inactive forms into the blood then becomes activated during cascade
Clotting factors
Where are clotting factors produced?
Liver
Plasma without clotting factors
Serum
When there’s collagen, activation of clotting factors
Intrinsic pathway
What is the common pathway for both intrinsic and extrinsic pathways?
Factor IX — Christmas Factor (Primary Thromboplastin Component)
Both pathways activate __________ to __________
Thrombin; Prothrombin
This converts plasminogen to plasmin
Plasminogen activators
Medication given to dissolve clots obstructing in coronary, pulmonary and cerebral arteries
Recombinant Tissue Plasminogen Activator (TPA)
This facilitates the swift removal of clotting factors and inhibition of active clotting factors becoming unnecessarily large
Clot controllers
Unbound thrombin is inactivated by __________ and __________
Antithrombin III; Protein C
This is an anticoagulant in mast cells and basophils, and on endothelial cells surface
Heparin
These are normally smooth and intact, preventing platelets from adhering
Endothelial cells
What are the secretions of endothelial cells that help prevent platelet aggregation?
- Nitric Oxide (NO)
- Prostacyclin
What are the three drugs used clinically to prevent clots?
- Aspirin
- Heparin
- Warfarin
It is an antiprotaglandin
Aspirin
It is injected clinically
Heparin
This is a coumadin taken orally
Warfarin
This clotting disorder can block vessel and if it’s large enough; not moving
Thrombus
This clotting disorder wedges in a vessel; moving
Embolus
Lack of platelets that causes spontaneous bleeding in small BVs
Thrombocytopenia
Causes lack of procoagulants
Impaired liver
What are the three types of Haemophilia?
- Lack of Factor VIII
- Lack of Factor IX
- Lack of Factor XI
Blood from heart to the body
Systemic loop
Oxygen-poor blood to the lungs and back to the heart
Pulmonary
What is the order of blood vessels?
Arteries —> Arterioles —> Capillaries —> Venules —> Veins
This carries oxygenated blood away from the heart.
Arteries
This carries deoxygenated blood back to the heart.
Veins
What are the factors that affect resistance?
- Blood viscocity
- Total blood vessel length
- Blood vessel diameter
What are the 4 layers of the heart?
- Epicardium
- Myocardium
- Endocardium
- Pericardium
This initiates heart beat and helps spread impulse rapidly throughout the heart
Conduction system
Peptide hormone secreted in atria
Atrial natriuretic peptide
This innervates entire heart and releases norepinephrine
Sympathetic Nervous System (SNS)
This innervates node cells and releases ACh
Parasympathetic Nervous System (PSNS)