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Cardiology Pharmacology > Cardio - heart failure meds > Flashcards

Cardio - heart failure meds Flashcards

1
Q

What is the drug class for Furosemide?

A 
The drug class for Furosemide is Diuretics: 
Loop diuretics
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2
Q

What is the MOA for Furosemide?

A

Furosemide inhibits Na+-K+-2Cl- symporter in TAL of Loop & distal tubule

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3
Q

What are the indications for Furosemide?

A

The indications for Furosemide are edema sec to CHF, Renal Failure, Liver Failure

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4
Q

What is the drug class for Torsemide?

A 
The drug class for Torsemide is Diuretics: 
Loop diuretics
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5
Q

What is the MOA for Torsemide?

A

Torsemide inhibits Na+-K+-2Cl- symporter in TAL of Loop & distal tubule

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6
Q

What are the indications for Torsemide?

A

The indications for Torsemide are edema of cardiac, renal, hepatic failure; HTN

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7
Q

What is the drug class for Ethacrynic Acid?

A 
The drug class for Ethacrynic Acid is Diuretics: 
Loop diuretics
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8
Q

What is the MOA for Ethacrynic Acid?

A

Ethacrynic Acid inhibits Na+-K+-2Cl- symporter in TAL of Loch & distal tubule

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9
Q

What are the indications for Ethacrynic Acid?

A

The indications for Ethacrynic Acid are edema sec to CHF, Renal Failure, Liver Failure

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10
Q

What is the drug class for Spironolactone?

A

The drug class for Spironolactone is Diuretics: Aldosterone Antagonists

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11
Q

What is the MOA for Spironolactone?

A

Spironolactone is an aldosterone receptor antagonist in distal renal tubule and blood vessels

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12
Q

What are the indications for Spironolactone?

A

The indications for Spironolactone are excessive aldosterone excretion or heart failure, hypertension, hypokalemia, liver cirrhosis with edema or ascites, nephrotic syndrome

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13
Q

What is the drug class for Eplerenone?

A

The drug class for Eplerenone is Diuretics: Aldosterone Antagonists

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14
Q

What is the MOA for Eplerenone?

A

Eplerenone is a more specific aldosterone receptor antagonist in kidney, heart, blood vessels, brain; reduces vascular & cardiac fibrosis

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15
Q

What are the indications for Eplerenone?

A

The indications for Eplerenone are excessive aldosterone excretion or heart failure, hypertension, hypokalemia, liver cirrhosis with edema or ascites, nephrotic syndrome

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16
Q

What is the drug class for Metoprolol Tartrate & Metoprolol Succinate?

A 
The drug class for Metoprolol Tartrate &  Metoprolol Succinate is Beta Blockers:
B1 Selective
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17
Q

What is the MOA for Metoprolol Tartrate & Metoprolol Succinate?

A

Metoprolol Tartrate & Metoprolol Succinate are selective antagonist(s) of B1 receptors at doses

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18
Q

What are the indications for Metoprolol Tartrate & Metoprolol Succinate?

A

The indications for Metoprolol Tartrate & Metoprolol Succinate are angina, HTN, and hemodynamicly stable AMI

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19
Q

What is the drug class for Carvedilol?

A 
The drug class for Carvedilol is Beta Blockers:
Non-selective
B1, B2, Alpha1
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20
Q

What is the MOA for Carvedilol?

A

Carvedilol is a nonselective B1 and B2 and Alpha1 blocking activity

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21
Q

What are the indications for Carvedilol?

A

The indications for Carvedilol are HF or ischemic cardiomyopathy, LVD following AMI

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22
Q

What is the drug class for Captopril?

A 
The drug class for Captopril is Vasodilators:
ACE Inhibitors
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23
Q

What is the MOA for Captopril?

A

Captopril is a competitive inhibitor of ACE preventing conversion Angiotensin I conversion to Angiotensin II decreasing vasoconstriction by Angiotensin II & decreases aldosterone secretion

24
Q

What are the indications for Captopril?

A

The indications for Captopril are hypertension, heart failure, left ventricular dysfunction after MI, diabetic nephropathy

25
Q

What is the drug class for Lisinopril?

A 
The drug class for Lisinopril is Vasodilators:
ACE Inhibitors
26
Q

What is the MOA for Lisinopril?

A

Lisinopril is a competitive inhibitor of ACE preventing conversion Angiotensin I conversion to Angiotensin II decreasing vasoconstriction by Angiotensin II & decreases aldosterone secretion

27
Q

What are the indications for Lisinopril?

A

The indications for Lisinopril are competitive inhibitor of ACE preventing conversion Angiotensin I conversion to Angiotensin II decreasing vasoconstriction by Angiotensin II & decreases aldosterone secretion

28
Q

What is the drug class for Fosinopril?

A 
The drug class for Fosinopril is Vasodilators:
ACE Inhibitors
29
Q

What is the MOA for Fosinopril?

A

Fosinopril is a competitive inhibitor of ACE preventing conversion Angiotensin I conversion to Angiotensin II decreasing vasoconstriction by Angiotensin II & decreases aldosterone secretion

30
Q

What are the indications for Fosinopril?

A

The indications for Fosinopril are competitive inhibitor of ACE preventing conversion Angiotensin I conversion to Angiotensin II decreasing vasoconstriction by Angiotensin II & decreases aldosterone secretion

31
Q

What is the drug class for Losartan?

A

The drug class for Losartan is Vasodilators:
Angiotensin 2 Receptor Blockers
ARBs

32
Q

What is the MOA for Losartan?

A

Losartan selectively & competitively blocks AT 1 (1000x greater) & AT2 receptors

33
Q

What are the indications for Losartan?

A

The indications for Losartan are hypertension, diabetic nephropathy in T2DM, stroke risk reduction in HTN, LVH

34
Q

What is the drug class for Amlodipine?

A

The drug class for Amlodipine is Vasodilators:
Calcium Channel Blockers-
Dihydropyridine

35
Q

What is the MOA for Amlodipine?

A

Amlodipine blocks calcium channel in vascular smooth muscle causing vasodilation; vasodilates coronary arteries

36
Q

What are the indications for Amlodipine?

A

The indications for Amlodipine are angina (chronic stable and vasospastic), HTN; not used specifically for HF but in people with HF and HTN

37
Q 
What is the drug class for Hydralazine &
Isosorbide Dinitrate?
A

Hydralazine & Isosorbide Dinitrate are Direct-Acting Vasodilators

38
Q

What is the MOA for Hydralazine &

Isosorbide Dinitrate?

A

Hydralazine & Isosorbide Dinitrate are direct acting arteriolar vasodilators

39
Q

What are the indications for Hydralazine &

Isosorbide Dinitrate?

A

The indications for Hydralazine &

Isosorbide Dinitrate are adjunctive treatment of HF, esp. in Afro-Americans

40
Q

What is the drug class for Digoxin?

A 
The drug class for Digoxin is Positive Inotropic Agents:
Cardiac Glycosides
41
Q

What is the MOA for Digoxin?

A

Digoxin inhibits Na/K ATPase pump in myocardial cells promoting influx Ca++ leading to increased contractility; also direct suppressor of AV node decr ventricular rate

42
Q

What are the indications for Digoxin?

A

The indications for Digoxin are mild to moderate HF; A fib rate control

43
Q

What is the drug class for Dobutamine?

A 
The drug class for Dobutamine is positive Inotropic Agents:
B-agonists
44
Q

What is the MOA for Dobutamine?

A

Dobutamine stimulates B1 adrenergic receptors increasing cardiac contractility and HR; little impact on B2 or alpha receptors

45
Q

What are the indications for Dobutamine?

A

The indications for Dobutamine are short-term management of cardiac decompensation

46
Q

What is the drug class for Milrinone?

A 
The drug class for Milrinone is Positive Inotropic Agents:
Phosphosdiesterase Inhibitors
47
Q

What is the MOA for Milrinone?

A

Milrinone is a selective PDE inhibitor in cardiac and vascular tissue producing vasodilation and inotropic effects with little chronotropic activity

48
Q

What are the indications for Milrinone?

A

The indications for Milrinone are short-term IV therapy of acutely decompensated HF

49
Q

What is the drug class for Nesiritide?

A 
The drug class for Nesiritide is miscellaneous:
Recombinant BNP
50
Q

What is the MOA for Nesiritide?

A

Nesiritide increases intracellular GMP in vascular smooth muscle cells and endothilium resulting in smooth muscle relaxation reducing pulmonary capillary wedge pressure (PCWP) & systemic arterial pressure

51
Q

What are the indications for Nesiritide?

A

The indications for Nesiritide are acutely decompensated HF with dyspnea at rest or with minimal activity

52
Q

What is the drug class for Aliskiren?

A 
The drug class for Aliskiren is miscellaneous:
Direct Renin Inhibitor
53
Q

What is the MOA for Aliskiren?

A

Aliskiren is a direct renin inhibitor preventing conversion of angiotensinogen to angiotensin I (AT1)which reduces conversion to angiotensin II (AT2) producing arteriolar vasodilation

54
Q

What are the indications for Aliskiren?

A

The indications for Aliskiren are Hypertension

55
Q

What is the drug class for Ivabradine?

A

The drug class for Ivabradine is miscellaneous:

56
Q

What is the MOA for Ivabradine?

A

Ivabradine acts to selectively and specificly inhibit If within SA node & prolonging diastolic depolarization and reducing HR

57
Q

What are the indications for Ivabradine?

A

The indications for Ivabradine are stable HF with EF 70 bpm & who are on max tolerated doses of B-blocker or unable to take B-blocker

Cardiology Pharmacology (4 decks)

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