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Cardio - heart failure meds Flashcards

1
Q

What is the drug class for Furosemide?

A 
The drug class for Furosemide is Diuretics: 
Loop diuretics
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2
Q

What is the MOA for Furosemide?

A

Furosemide inhibits Na+-K+-2Cl- symporter in TAL of Loop & distal tubule

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3
Q

What are the indications for Furosemide?

A

The indications for Furosemide are edema sec to CHF, Renal Failure, Liver Failure

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4
Q

What is the drug class for Torsemide?

A 
The drug class for Torsemide is Diuretics: 
Loop diuretics
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5
Q

What is the MOA for Torsemide?

A

Torsemide inhibits Na+-K+-2Cl- symporter in TAL of Loop & distal tubule

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6
Q

What are the indications for Torsemide?

A

The indications for Torsemide are edema of cardiac, renal, hepatic failure; HTN

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7
Q

What is the drug class for Ethacrynic Acid?

A 
The drug class for Ethacrynic Acid is Diuretics: 
Loop diuretics
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8
Q

What is the MOA for Ethacrynic Acid?

A

Ethacrynic Acid inhibits Na+-K+-2Cl- symporter in TAL of Loch & distal tubule

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9
Q

What are the indications for Ethacrynic Acid?

A

The indications for Ethacrynic Acid are edema sec to CHF, Renal Failure, Liver Failure

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10
Q

What is the drug class for Spironolactone?

A

The drug class for Spironolactone is Diuretics: Aldosterone Antagonists

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11
Q

What is the MOA for Spironolactone?

A

Spironolactone is an aldosterone receptor antagonist in distal renal tubule and blood vessels

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12
Q

What are the indications for Spironolactone?

A

The indications for Spironolactone are excessive aldosterone excretion or heart failure, hypertension, hypokalemia, liver cirrhosis with edema or ascites, nephrotic syndrome

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13
Q

What is the drug class for Eplerenone?

A

The drug class for Eplerenone is Diuretics: Aldosterone Antagonists

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14
Q

What is the MOA for Eplerenone?

A

Eplerenone is a more specific aldosterone receptor antagonist in kidney, heart, blood vessels, brain; reduces vascular & cardiac fibrosis

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15
Q

What are the indications for Eplerenone?

A

The indications for Eplerenone are excessive aldosterone excretion or heart failure, hypertension, hypokalemia, liver cirrhosis with edema or ascites, nephrotic syndrome

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16
Q

What is the drug class for Metoprolol Tartrate & Metoprolol Succinate?

A 
The drug class for Metoprolol Tartrate &  Metoprolol Succinate is Beta Blockers:
B1 Selective
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17
Q

What is the MOA for Metoprolol Tartrate & Metoprolol Succinate?

A

Metoprolol Tartrate & Metoprolol Succinate are selective antagonist(s) of B1 receptors at doses

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18
Q

What are the indications for Metoprolol Tartrate & Metoprolol Succinate?

A

The indications for Metoprolol Tartrate & Metoprolol Succinate are angina, HTN, and hemodynamicly stable AMI

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19
Q

What is the drug class for Carvedilol?

A 
The drug class for Carvedilol is Beta Blockers:
Non-selective
B1, B2, Alpha1
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20
Q

What is the MOA for Carvedilol?

A

Carvedilol is a nonselective B1 and B2 and Alpha1 blocking activity

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21
Q

What are the indications for Carvedilol?

A

The indications for Carvedilol are HF or ischemic cardiomyopathy, LVD following AMI

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22
Q

What is the drug class for Captopril?

A 
The drug class for Captopril is Vasodilators:
ACE Inhibitors
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23
Q

What is the MOA for Captopril?

A

Captopril is a competitive inhibitor of ACE preventing conversion Angiotensin I conversion to Angiotensin II decreasing vasoconstriction by Angiotensin II & decreases aldosterone secretion

24
Q

What are the indications for Captopril?

A

The indications for Captopril are hypertension, heart failure, left ventricular dysfunction after MI, diabetic nephropathy

25
What is the drug class for Lisinopril?
``` The drug class for Lisinopril is Vasodilators: ACE Inhibitors ```
26
What is the MOA for Lisinopril?
Lisinopril is a competitive inhibitor of ACE preventing conversion Angiotensin I conversion to Angiotensin II decreasing vasoconstriction by Angiotensin II & decreases aldosterone secretion
27
What are the indications for Lisinopril?
The indications for Lisinopril are competitive inhibitor of ACE preventing conversion Angiotensin I conversion to Angiotensin II decreasing vasoconstriction by Angiotensin II & decreases aldosterone secretion
28
What is the drug class for Fosinopril?
``` The drug class for Fosinopril is Vasodilators: ACE Inhibitors ```
29
What is the MOA for Fosinopril?
Fosinopril is a competitive inhibitor of ACE preventing conversion Angiotensin I conversion to Angiotensin II decreasing vasoconstriction by Angiotensin II & decreases aldosterone secretion
30
What are the indications for Fosinopril?
The indications for Fosinopril are competitive inhibitor of ACE preventing conversion Angiotensin I conversion to Angiotensin II decreasing vasoconstriction by Angiotensin II & decreases aldosterone secretion
31
What is the drug class for Losartan?
The drug class for Losartan is Vasodilators: Angiotensin 2 Receptor Blockers ARBs
32
What is the MOA for Losartan?
Losartan selectively & competitively blocks AT 1 (1000x greater) & AT2 receptors
33
What are the indications for Losartan?
The indications for Losartan are hypertension, diabetic nephropathy in T2DM, stroke risk reduction in HTN, LVH
34
What is the drug class for Amlodipine?
The drug class for Amlodipine is Vasodilators: Calcium Channel Blockers- Dihydropyridine
35
What is the MOA for Amlodipine?
Amlodipine blocks calcium channel in vascular smooth muscle causing vasodilation; vasodilates coronary arteries
36
What are the indications for Amlodipine?
The indications for Amlodipine are angina (chronic stable and vasospastic), HTN; not used specifically for HF but in people with HF and HTN
37
``` What is the drug class for Hydralazine & Isosorbide Dinitrate? ```
Hydralazine & Isosorbide Dinitrate are Direct-Acting Vasodilators
38
What is the MOA for Hydralazine & | Isosorbide Dinitrate?
Hydralazine & Isosorbide Dinitrate are direct acting arteriolar vasodilators
39
What are the indications for Hydralazine & | Isosorbide Dinitrate?
The indications for Hydralazine & | Isosorbide Dinitrate are adjunctive treatment of HF, esp. in Afro-Americans
40
What is the drug class for Digoxin?
``` The drug class for Digoxin is Positive Inotropic Agents: Cardiac Glycosides ```
41
What is the MOA for Digoxin?
Digoxin inhibits Na/K ATPase pump in myocardial cells promoting influx Ca++ leading to increased contractility; also direct suppressor of AV node decr ventricular rate
42
What are the indications for Digoxin?
The indications for Digoxin are mild to moderate HF; A fib rate control
43
What is the drug class for Dobutamine?
``` The drug class for Dobutamine is positive Inotropic Agents: B-agonists ```
44
What is the MOA for Dobutamine?
Dobutamine stimulates B1 adrenergic receptors increasing cardiac contractility and HR; little impact on B2 or alpha receptors
45
What are the indications for Dobutamine?
The indications for Dobutamine are short-term management of cardiac decompensation
46
What is the drug class for Milrinone?
``` The drug class for Milrinone is Positive Inotropic Agents: Phosphosdiesterase Inhibitors ```
47
What is the MOA for Milrinone?
Milrinone is a selective PDE inhibitor in cardiac and vascular tissue producing vasodilation and inotropic effects with little chronotropic activity
48
What are the indications for Milrinone?
The indications for Milrinone are short-term IV therapy of acutely decompensated HF
49
What is the drug class for Nesiritide?
``` The drug class for Nesiritide is miscellaneous: Recombinant BNP ```
50
What is the MOA for Nesiritide?
Nesiritide increases intracellular GMP in vascular smooth muscle cells and endothilium resulting in smooth muscle relaxation reducing pulmonary capillary wedge pressure (PCWP) & systemic arterial pressure
51
What are the indications for Nesiritide?
The indications for Nesiritide are acutely decompensated HF with dyspnea at rest or with minimal activity
52
What is the drug class for Aliskiren?
``` The drug class for Aliskiren is miscellaneous: Direct Renin Inhibitor ```
53
What is the MOA for Aliskiren?
Aliskiren is a direct renin inhibitor preventing conversion of angiotensinogen to angiotensin I (AT1)which reduces conversion to angiotensin II (AT2) producing arteriolar vasodilation
54
What are the indications for Aliskiren?
The indications for Aliskiren are Hypertension
55
What is the drug class for Ivabradine?
The drug class for Ivabradine is miscellaneous:
56
What is the MOA for Ivabradine?
Ivabradine acts to selectively and specificly inhibit If within SA node & prolonging diastolic depolarization and reducing HR
57
What are the indications for Ivabradine?
The indications for Ivabradine are stable HF with EF 70 bpm & who are on max tolerated doses of B-blocker or unable to take B-blocker

Cardiology Pharmacology (4 decks)

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