Cardio core conditions Flashcards
What is the presenting complaint for a patient with unstable angina?
Angina with increased frequency , unpredictability or at rest
Pain lasts <20mins
What is the minimum amount of time for chest pain to last to consider the cause being a STEMI or an nSTEMI?
> 20mins
What will an ECG show in unstable angina?
May be normal
May show ST depression or T wave changes
What is acute coronary syndrome?
Unstable angina and an evolving MI (STEMI or NSTEMI)
What will an ECG show in a STEMI?
ST elevation
T wave inversion
What will an ECG show for an NSTEMI
ST depression or T wave inversion
What happens to troponin levels in UA, STEMI, NSTEMI?
UA: normal
STEMI and NSTEMI: elevated
What do the majority of patients with ST elevation develop?
Q wave MI
What are the the symptoms of an MI? 6
1- chest pain >20mins often unresponsive to GTN spray 2-radiates to neck and down left arm 3- nausea 4-sweating 5- dyspnoea 6-palpitations
How do elderly or diabetic patients present with an MI? 9
1- dyspnoae 2-fatigue 3-syncope 4-epigastric pain 5-oliguria 6-pulmonary oedema 7-acute confused state 8-stroke 9- diabetic hyperglycaemic attacks
What will the pulse feel like in an MI?
Thready= a weak pulse that is difficult to feel or obliterated easily with slight pressure
What happens to BP in MIs?
It decreases
What other signs will be seen in an MI (aside from low BP and thready pulse)? 5
1- 4th heart sounds 2- signs of heart failure= increased JVP, 3rd heart sound, basal crepitations 3- pansystolic murmur 4- later a pericardial friction rub 5- later peripheral oedema may develop
What are the risk factors for an MI? 9
1- age >65 2- Male 3- Fh of IHD 3- smoking 4- hypertension 5- DM 6- hyperlipidaemia 7-obesity 8- stress 9- type A personality
What will an ECG show in a STEMI over time?
Hours: T wave peaks, ST segments may begin to rise
within 24 hours: T wave inverts as ST elevation begins to resolve
within a few days: pathological Q waves form, these usually persist
What will a CXR show in a MI?
Cardiomegaly
pulmonary oedema
widened mediastinum
What biochemical markers are tested for an MI? 3
Creatine kinase MB
Troponin
Myoglobin (useful for rapid diagnosis of ACS, but not specific- also found in muscles)
Why is creatine kinase tested less frequently now?
As there are low levles in the serum of normal people and people with skeletal damage, prolonged exercise, Afro-carribeans, hypothermia and hypothyroidism
Which parts of troponin are tested for in an MI?
mAB against troponin T
mAB against troponin I
What do each of the parts of troponin do?
T: attaches the complex to tropomyosin
C: binds calcium during excitation contraction coupling
I: inhibits the myosin binding site of the actin. Isn’t found in normal people
When do Troponin T levels peak and for how long post MI can they be detected?
12-24 hours
for a week
What are the criteria for MI diagnosis?
2/3 of:
chest pain/ typical history
ECG changes
cardiac enzyme ris
How do you manage high death risk patients with an MI?
urgent coronary angiography?
How do you manage low risk MI patients?
aspirin, clopidpgrel, beta blockers and nitrates