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Year 1: Drug Revision > Cardio: Anti-Arrythmic Drugs > Flashcards

Cardio: Anti-Arrythmic Drugs Flashcards

1
Q

What do class 1 drugs act on? Which phase of the action potential is this?

A

Voltage activated sodium channels

Phase 0

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2
Q

Which drug is an example of a class 1A anti-arhythmic drug?

A

Quinidine

Disopyramide

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3
Q

Which drug is an example of a class 1B anti-arhythmic drug?

A

Lignocaine

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4
Q

Which drug is an example of a class 1C anti-arhythmic drug?

A

Flecainide

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5
Q

What are class 1 anti-arhythmic drugs used to treat?

A

Paroxysmal AF

Prevention of ventricular tachycardia

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6
Q

Which class 1 drug is given to manage rhythm in chronic AF where there is no underlying heart disease?

A

Flecainide

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7
Q

Which class 1 drug is given post MI to prevent ventricular tachycardia/fibrillation?

A

Lignocaine

‘Say no to ventricular tachycardia’ - ligNOcaine

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8
Q

Which drugs are class 2 anti-arhythmic drugs?

A

Beta-blockers

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9
Q

How do class 2 drugs work?

A

Counter elevated sympathetic activity
Increase refractory period
Decrease firing of SA node

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10
Q

What are beta-blockers used to treat?

A

Rate control in AF

Persistent sinus tachycardia

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11
Q

What are the main side effects of beta-blockers?

A 
Bronchospasm
Cold peripheries 
Hypoglycaemia 
Lethargy 
Aggravation of HF
Bradycardia
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12
Q

Which phase of the action potential do beta-blockers work on?

A

Phase 0

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13
Q

What do class 3 drugs work on? Which phase of the action potential is this?

A

Voltage activated potassium channels

Phase 3

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14
Q

Which drugs are example of class 3 anti-arrythmics?

A

Amiodarone

Stall

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15
Q

How do class 3 drugs affect the action potential?

A

Prolong the action potential

Increase refractory period

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16
Q

What is amiodarone used to treat?

A

Ventricular tachycardia
WPW syndrome
Rhythm control in AF patients with underlying heart disease
Atrial flutter

17
Q

What is sotalol used to treat?

A

Paroxysmal SVTs

18
Q

What are the main side affects of amiodarone?

A

Blue/slate grey skin
Thyroid abnormalities
Pulmonary fibrosis

19
Q

What type of drug are class 4 anti-arhythmic drugs?

A

Calcium channel blockers

20
Q

Which phase of the action potential do class 4 drugs act on?

A

Phase 2

21
Q

Which type of calcium channel blocker is preferred in the treatment of arrhythmias?

A

Drugs selective for cardiac L type calcium channels, e.g. verapamil

22
Q

When is verapamil contraindicated?

A

In conjunction with beta blockers

WPW syndrome

23
Q

When is verapamil used?

A

Rate control in AF

SVT once vagal manœuvres + adenosine fail

24
Q

How is a ventricular tachycardia due to hypokalaemia treated?

A

IV magnesium sulphate

Year 1: Drug Revision (15 decks)

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