Cardio Flashcards
RE-LY - 2009
Noninferiority trial
Dabigatran vs Warfarin
Warfarin reduces stroke risk by
~55%
AFFIRM - 2002
Pts w non-valvular AF
Rate vs rhythm control non-inferior,
Rhythm control shows trends towards increased mortality
RACE II -2010
Lenient (HR <80/min) in preventing cardiovascular events
Antiarrythmic drugs - Class I
NaCB
1a - procainamide, quinidine
1b - lidocaine
1c - flecanaide, propafenone
Anti arrhythmic drugs - Class II
BBs
Anti arrhythmic drugs - Class III
KCBs
Amiodarone, sotalol, dofetilide
Anti arrhythmic drugs - Class IV
CCBs
Digoxin
Na-K ATPase inhibitor: increases contractility (IC Na increases, resulting in Ca influx)
AV node blockade - increases effective refractory period, slows heartrate
Inotropic effect
+ increases myocardium contractility
- decreases myocardium contractility
Chronotropic effect
+ increases HR
- decreases HR
Dromotropic effect
+ increases AV node conduction speed
- decreases Av node conduction speed
Maintenance of Sinus rythtm if no Heart disease (and HTN without LVH)
1st choice: flecanaide, propafenone, sotalol
2nd line: amio, dofetilide, cath ablation
Maintenance of sinus rhythm if HTN & LVH
1st line: amio
2nd line: cath ablation
Maintenance of sinus rhythm if CAD
1st line: dofetilide, sotalol
2nd line: amio or cath ablation
Maintenance of sinus rhythm if CHF
1st line: amio, dofetilide
2nd line: cath ablation