Cardio Flashcards
Acute autoimmune inflammatory multi-systemic illness sequela of a beta-hemolytic streptococcal infx of the pharynx
Rheumatic fever
Pathophys of Acute rheumatic fever
Symptomatic or asymptomatic infection with Group A Streptococcus (aka Strep pyogenes) stimulates antibody production to host tissues & damages organs directly
Children 5-15 years old
Major criteria for acute rheumatic fever
JONES = Joint (migratory polyarthritis), Oh (active carditis), Nodules (Subcutaneous), Erythema marginatum (macular erythematous non pruritic annular rash), Sydenham’s chorea
Minor criteria for acute rheumatic fever
Arthralgia
Fever 101.3 +
EKG = prolonged PR
Elevated CRP/ESR
Leukocytosis
Dx of acute rheumatic fever
Jones criteria for rheumatic fever – 2 Major OR 1 Major + 2 Minor PLUS Supporting evidence of recent strep infx
Tx of rheumatic fever
Anti-inflammatory: Aspirin (2-6 weeks with taper) +/- corticosteroids in severe cases & carditis
Penicillin G – antibiotic of choice (or erythromycin if PCN allergic) both in acute phase & after acute episode
Prevention is the most important therapeutic course – therefore all patients should be treated w/ abx
Biggest complication from rheumatic fever
Rheumatic valve dz = mitral (75-80%), aortic (30%), tricuspid & pulmonic (5%)
Abnormal opening in the atrial septum between the right & left atrium → volume overload of right atrium & ventricle
Atrial septal defect
MC type of atrial septal defect
ostium secundum
2nd MC congenital heart dz
Atrial septal defect
Sx of atrial septal defect
Infants & young children: recurrent respiratory infx, failure to thrive, DOE
Adolescents & young adults: exertional dyspnea, easy fatigability, palpitations, atrial arrhythmias, syncope, heart failure
Over 30 – dyspnea & chest pain, over 50 – afib & RVF
PE findings of atrial septal defect
Systolic ejection crescendo-decrescendo flow murmur @ pulmonic area (LUSB – 2nd or 3rd intercostal space)
Wide, fixed split S2 that does not vary with respirations, loud S1 & hyperdynamic right ventricle
Dx of Atrial septal defect
Echo = best test
Tx of ASD
Small ASD < 5mm may be observed (most small ASD spontaneously close in the first year of life)
Symptomatic treatment: Diuretics, ACE inhibitors, digoxin
Surgical correction: 1cm+/symptomatic (between 2-4 y/o) → perQ transcatheter closure v. surgical intervention
Persistent communication between the descending thoracic aorta & main pulmonary artery after birth
Patent ductus arteriosus
Pathophys for PDA
Continued prostaglandin E1 production & low arterial oxygen content promotes patency
Acyanotic vs cyanotic heart disease
Acyanotic = defect in which oxygen levels delivered to the body remain normal = VSD, PDA, ASD, AV Canal
*VSD = MC Acyanotic type
Cyanotic= Transposition of great arteries, terat of fallot, tricuspid valve abnormalities