Cardiac SEE Flashcards
What is
Inotropy
Chronotropy
Dromotropy
Lusitropy
Inotropy - Contractility
Chronotropy - HR
Dromotropy - Conduction velocity
Lusitropy - Myocardial relaxation during diastole
What is the RMP and TP of the cardiac myocyte?
TP, -55
RMP, -70
What happens to the RMP when potassium is increased or decreased
Decreased K - Decreases RMP
Increased K - Increases RMP
What is the primary determinant of TP? How does hyper/hypo affect it?
Ca
Increased Ca - TP becomes positive
Decreased Ca - TP becomes more negative
What happens when RMP becomes closer to TP? What about further away?
Closer - more easily depolarized
Further - Harder to depolarize
What is the sodium-potassium ATPase pump?
Restores balance towards RMP
For every 3 Na lost, 2 K enters the cell
What drug inhibits the Sodium-potassium ATPase pump?
Digoxin
Cardiac Conduction
What happens in phase 0 of the myocyte action potential
Sodium enters the ICF
(depolarization)
What happens in phase 1 of the myocyte action potential
Cl- enters the ICF
K+ leaves the ICF
(Initial repolarization)
What happens in phase 2 of the myocyte action potential
Ca+ enters and K+ leaves
(Plateau)
What happens in phase 3 of the myocyte action potential
K leaves the ICF
(Final repolarization)
What happens in phase 4 of the myocyte action potential
Resting phase
K out
Na/K/ATPase pump working
Between what phases is the absolute refractory period?
End of phase 1 to middle of phase 3
When is the relative refractory period?
End of phase 3
What is the conduction pathway through the heart?
SA node
Internodal Tracts
AV node
Bundle of HIS
Bundle branches
Purkinje fibers
Cardiac conduction potential
What is phase 4 of the cardiac conduction potential?
Spontaneous depolarization
Na in through leaky channels
Ca channels open (T type)
What is phase 0 of the cardiac conduction potential?
Depolarization
Ca enters through L channels