CARDIAC PHARMACOLOGY (HYPERLIPIDEMIA) Flashcards
how to treat HYPERLIPIDEMIA
increase HDL
decrease LDL
decrease TRIGLYCERIDES
enzyme responsible for the production of cholesterols
HMG-CoA REDUCTASE
managing HYPERLIPIDEMIA
- inhibit HMG-CoA REDUCTASE
- increase LDL receptors on HEPATOCYTES
- increase lipoprotein lipase
- decrease VLDL production
increase in lipoprotein lipase results to
increase peripheral clearance of lipoproteins
agent that decreases cholesterol synthesis in the liver
HMG-CoA REDUCTASE INHIBITORS
drugs that lowers cholesterol levels
ARTOVASTATIN, LOVASTATIN, PRAVASTATIN, SIMVASTATIN
trade name of ARTOVASTATIN
LIPITOR
trade name of SIMVASTATIN
PROVAST
SE of HMG-CoA REDUCTASE INHIBITORS
- increase in serum transaminases
- muscle tenderness
agent that increases LDL receptors on hepatocytes and decreases bile acid absorption
BILE ACID SEQUESTRANTS
BILE ACID SEQUESTRANTS
CHOLESTYRAMINE & COLESTIPOL
SE of BILE ACID SEQUESTRANTS
- constipation
- flatulence
increases activity of lipoprotein lipase, thus enhances clearance of triglycerides
FIBRIC ACID DERIVATIVES
FIBRIC ACID DERIVATIVES
- GEMFIBROZIL
- CLOFIBRATE
- BENZAFIBRATE
- FENOFIBRATE
SE of FIBRIC ACID DERIVATIVES
- flushing
- rashes
- itchiness
trade name of GLEMFIBROZIL
LOPID
agent that decreases production of VLDL
NICOTINIC ACID
precursor of LDL
VLDL
NICOTINIC ACID
NIACIN
SE of NICOTINIC ACID
- flushing
- rashes
- itchiness
agents would be more toxic if
COMBINED
used for assessing if there is still a need to take drugs for HYPERLIPIDEMIA
SERUM CHOLESTEROL
