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PHARMACOLOGY > CARDIAC PHARMACOLOGY (HYPERLIPIDEMIA) > Flashcards

CARDIAC PHARMACOLOGY (HYPERLIPIDEMIA) Flashcards

1
Q

how to treat HYPERLIPIDEMIA

A

increase HDL
decrease LDL
decrease TRIGLYCERIDES

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2
Q

enzyme responsible for the production of cholesterols

A

HMG-CoA REDUCTASE

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3
Q

managing HYPERLIPIDEMIA

A
  • inhibit HMG-CoA REDUCTASE
  • increase LDL receptors on HEPATOCYTES
  • increase lipoprotein lipase
  • decrease VLDL production
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4
Q

increase in lipoprotein lipase results to

A

increase peripheral clearance of lipoproteins

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5
Q

agent that decreases cholesterol synthesis in the liver

A

HMG-CoA REDUCTASE INHIBITORS

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6
Q

drugs that lowers cholesterol levels

A

ARTOVASTATIN, LOVASTATIN, PRAVASTATIN, SIMVASTATIN

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7
Q

trade name of ARTOVASTATIN

A

LIPITOR

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8
Q

trade name of SIMVASTATIN

A

PROVAST

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9
Q

SE of HMG-CoA REDUCTASE INHIBITORS

A
  • increase in serum transaminases

- muscle tenderness

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10
Q

agent that increases LDL receptors on hepatocytes and decreases bile acid absorption

A

BILE ACID SEQUESTRANTS

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11
Q

BILE ACID SEQUESTRANTS

A

CHOLESTYRAMINE & COLESTIPOL

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12
Q

SE of BILE ACID SEQUESTRANTS

A
  • constipation

- flatulence

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13
Q

increases activity of lipoprotein lipase, thus enhances clearance of triglycerides

A

FIBRIC ACID DERIVATIVES

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14
Q

FIBRIC ACID DERIVATIVES

A
  • GEMFIBROZIL
  • CLOFIBRATE
  • BENZAFIBRATE
  • FENOFIBRATE
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15
Q

SE of FIBRIC ACID DERIVATIVES

A
  • flushing
  • rashes
  • itchiness
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16
Q

trade name of GLEMFIBROZIL

A

LOPID

17
Q

agent that decreases production of VLDL

A

NICOTINIC ACID

18
Q

precursor of LDL

A

VLDL

19
Q

NICOTINIC ACID

A

NIACIN

20
Q

SE of NICOTINIC ACID

A
  • flushing
  • rashes
  • itchiness
21
Q

agents would be more toxic if

A

COMBINED

22
Q

used for assessing if there is still a need to take drugs for HYPERLIPIDEMIA

A

SERUM CHOLESTEROL

PHARMACOLOGY (7 decks)

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