Cardiac Pathology Part I Flashcards
what valvular changes occur with age?
fibrous mitral valve –> atrial dilation and arhythmia
calcium deposits –> aortic stenosis and CHF
lambl excrescenses
what changes occur to the chambers of the heart with age?
left ventricular hypertrophy secondary to HTN
atrial dilation
what atherosclerotic changes occur with age?
stenosis –> MI, aortic dissection, etc.
what changes occur to the epicardium and myocardium with age?
increased epicardial fat lipofuscin accumulation basophilic degeneration myocyte loss amyloid deposition –> senile amyloidosis –> CHF
what causes pump failure?
inadequate contraction (systole) inadequate filling (diastole)
what causes flow obstruction?
increased resistance pressure (stenosis, HTN)
decreased blood flow (atherosclerosis, ischemia)
what causes regurgitant flow?
incompetent valve
what causes shunted flow?
congenital disease (VSD, ASD or PDA) post-MI
what causes cardiac conduction abnormalities?
ischemic injury
heritable arrhythmias
what causes vessel rupture?
aortic dissection
trauma (MVC)
what occurs with MVC trauma reguarding the heart?
blow to the chest may cause tearing of the ligamentum arteriosum
results in aortic dissection
what is the most important measurement in cardiomegaly?
weight NOT wall thickness
what is congestive heart failure (CHF)?
progressive pump failure causing poor blood delivery
diastolic –> inability to fill ventricles
systolic–> inability to empty ventricles
what causes systolic dysfunction?
ischemic injury
dilated cardiomyopathy
valve regurgitation
what EF changes are consistent with systolic dysfunction?
decreased EF
what causes diastolic dysfunction?
HTN --> LVH aortic stenosis --> LVH hypertrophic cardiomyopathy fibrosis restrictive cardiomyopathy
what EF changes are consistent with diastolic dysfunction?
normal EF but lower total volume due to less filling
what causes left CHF?
myocardial ischemia
HTN
left valve disease (aortic/mitral)
what is the clinial presentation of left CHF?
pulmonary congestion (crackles) low tissue perfusion paroxysmal nocturnal dyspnea orthopnea dyspnea on exertion cyanosis confusion due to low cerebral perfusion azotemia due to low renal perfusion
what would be seen on CXR for a patient with left CHF?
Kerley B lines
what histologic findings would be seen on a patient with left CHF?
hemosiderin-laden macrophages
what is the most common cause of right CHF?
left CHF
*increases pulmonary pressure which results in right CHF
what causes isolated right CHF?
parenchymal lung disease (most common)
lung thromboemboli
primary pulmonary HTN (rare)
what is the clinical presentation of right CHF?
HSM (nutmeg liver) distended veins LE edema exertional dyspnea ascites weight gain
what is the most common congenital heart disease?
septal defects (ASD or VSD)
which septal defect is most common?
VSD
what is the most common cause of genetic heart disease?
Down syndrome
what defects are associated with down syndrome?
VSD or ASD
what is marfan syndrome and what cardiac defects are associated with it?
Fibrillin-1 mutation causing defective TGF-B activity
aortic aneurysm
aortic dissection
mitral or aortic valve prolapse
what is DiGeorge syndrome?
CATCH-22
cardiac abnormalities abnormal facies thymic aplasia cleft palate hypocalcemia 22q11 deletion
what cardiac defects are associated with DiGeorge syndrome?
tetrology of Fallot
transposition of great vessels
ASD
VSD
what cardiac defects are associated with Turner syndrome (45, XO)?
coarctation of the aorta
what cardiac defects are associated with Trisomy 18 and 13?
PDA
VSD
ASD
what are examples of a left-to-right shunt?
ASD
VSD
PDA
how do patients with a left-to-right shunt present?
asymptomatic without cyanosis