Angina and ACS Flashcards
Stable Angina
CP for >2m precipitated by exertion or emotional distress that is not getting worse
3 types of ACS
- Unstable Angina
- NSTEMI
- STEMI
Difference between unstable angina and NSTEMI
NSTEMI= elevated cardiac enzymes
Modifiable risk factors for development of CAD
HHCD
- Hyperlipidemia
- HTN
- Cigarrette smoking
- Diabetes (bedus)
What are CKD, proteinuria, and chronic inflammatory states risk factors for?
CAD
Explain the steps of plaque formation (5 steps)
- Endothelial injury
- LDL and Macrophage deposition
- Foam cell formation
- smooth muscle recruitment into tunica intima
- deposition of ECM
Fibrous Cap with a Necrotic Center
3 outcomes of atherslerotic plaque deposition
- Aneurysm and Rupture
- Occlusion via Thrombus
- Stenosis
Clinical presentation of ACS
CP that radiates to neck, jaw, arms (angina pectoris) Dyspnea NV Diaphoresis Fatigue
What groups of people should you suspect atypical presentations of ACS in?
Elderly
Women
Wilford Brimley (Diabetics)
Diamond Forrester Criteria of CP
- Substernal CP
- Provoked by exertion/emotion
- Relieved by Nitro
Using the Diamond Forrester Criteria, define typical, atypical, and Non-Angina CP
Typical- all 3 components
Atypical- 2/3
Non-Anginal- <1
What would you see on ECG in stable angina, unstable angina, NSTEMI, and STEMI?
Stable= NORMAL Unstable/NSTEMI= ST depression/Inverted T wave STEMI= ST elevation with hyper acute T wave
Different stressors of a cardiac stress test
- Exercise
2. Pharmacology- Vasodilators or Dobutamine
3 testing modalities of a stress test
- Stress ECG
- ECHO
- Myocardial Perfusion Imaging (MPI)
If a person has abnormalities on ECG during a stress test, what is the next step of treatment?
Coronary Angiography
STEMI ECG criteria
ST elevation >2mm in continuous leads or new LBBB
NSTEMI ECG criteria
- New ST depression >0.5mm in two contiguous leads
- T wave inversions
- prominent R waves (R/S ratio >1)
What usually precipitates a STEMI vs a NSTEMI?
STEMI- occlusion of blood flow in a coronary vessel
NSTEMI- partial occlusion or complete occlusion with collateral flow
When do Troponins typically peak?
10-24h
Treatment of Stable Angina
Lifestyle mods
Aspirin
Statin
Anti-Anginal drugs: B-blockers, CCB
Describe External Enhanced Counterpulsations (EECP) Therapy
Option to treat stable Angina. Compresses LE’s during diastole
CABG Indications
- 3 vessels @ >70% stenosis
- Left main artery disease
- LV dysfxn
Describe MONA treatment for ACS
Morphine
Oxygen
Nitrates
Aspirin
Antiplatelet therapy
Dual Antiplatelet Therapy (DAPT)
Aspirin and P2Y12 Inhibitor
Drugs shown to improve mortality rates in MI patients
- ASA
- B-blockers
- ACE Inhbitors
Why does Aspirin help decrease platelet aggregation?
COX1 and COX2 Inhibition leads to decreased Thromboxane A2.
Management of a STEMI
Percutaneous Coronary Intervention (PCI=Cath Lab) capable hospital: <90m
Non-PCI: If PCI is <120m away, transfer or Thrombolytics <30m then transfer
Inferior MI’s are usually due to what artery occlusion?
LCx or RCA
Lateral MI artery occlusion
LCx or branch of LAD
Anterior MI artery occlusion
LAD
Dressler Syndrome
Post MI autoimmune reaction that causes pericarditis
Ddx of Acute MI should include what other 2 things?
- PE
2. Aortic Dissection
Stanford Classification of Aortic Dissections
Type A: Involves the ascending aorta
Type B: No ascending Aorta
Which stanford classification type of Aortic Dissections is the most common?
Type A
What risk factors are associated with a young person having an aortic dissection?
CT disorders
Nose candy
Trauma
3 ways an aortic dissection can occur
- Tear in the intima that creates a false lumen
- Intramural hematoma caused by rupture of vasa vasorum
- Athersclerotic plaque ulcerating through intima and causing a hematoma
Classic presentation of an aortic dissection
Tearing pain that radiates to the back
Remember also on the Ddx is: MI, PE
Other findings: Tamponade, Horner Syndrome, Mesenteric Ischemia, Hemothorax, MI, Aortic Regurge (diastolic murmur)
Most commonly used imaging method to diagnosis aortic dissection
CT Angiography
Anti-impulse therapy for Aortic Dissection
IV-Beta blockers +/- Vasodilators to get BP <120 and HR<60
Which Stanford classification of Aortic Dissection has a higher mortality rate?
Type A- surgical management needed