Cardiac Drugs (42) Flashcards
Cardiac Functions:
____ –> contraction
Chronotropic –> ____
____ –> electrical impulses
inotropic… heart rate… dromotropic..
Cardiac glycosides:
____ & similar drugs –> ____ plant (digitalis)
Digoxin… Foxglove
Congestive Heart Failure (CHF) –> ____ can’t pump entire amount of blood received, which causes cardiac ____.
ventricles… distention.
CHF heart adapts leads to ____.
Decrease of renal blood flow, which leads to ____ and ____ retention.
hypertrophy…Na+ & water.
CHF Signs and Symptoms: Weight \_\_\_\_ Edema SOB Pulmonary \_\_\_\_
gain… congestion
Cardiac glycosides give a ____ inotropic action, which ____ force of heart contraction –> will ____ mechanical efficiency which will ____ size of heart.
positive…increases… increase… decreases
Positive inotropic action of cardiac glycosides –> it increases ____ to kidneys, which will have a ____ effect and relieve ____ retention
blood flow… diuretic… Na+ & water
Negative chronotropic action of cardiac glycosides –> slows heart rate (Tx: CHF, ____)
arrhythmias…
Stay with the ____ brand when choosing the drug of choice for cardiac effects.
same
Digitoxin - rarely prescribed but has a very long half-life.
Digoxin (Lanoxin) - commonly used
DO NOT ____ THE TWO.
CONFUSE
Digitalization - bring ____ levels up to therapeutic levels
serum
Dosage of Digoxin/Digitoxin:
Digitalization - p.o. 0.5 - 1mg in 2 divided doses.
Maintenance - p.o. 0.125 - 0.5 mg/day
SEE OTHER SIDE
What are the therapeutic blood levels 0.8 - 2mg
Low therapeutic index - very low to toxic levels so monitor clients.
SEE OTHER SIDE
S/S Drug toxicity of Digoxin/Digitoxin:
GI distress (n/v, diarrhea, abd pain)
Euro effects (visual disturbances, restless, ____)
Cardiac effects: ____
HA…Bradycardia
Predisposing factors to toxicity:
Hypokalemia
____ impairment
IV drug administration
renal…
Antidote for severe intoxication:
Digoxin ____ - binds with digoxin and forms complex molecules that are then excreted in the ____.
immune fab… urine.
milrinone lactate (Primacor) gives a \_\_\_\_ inotropic effect on heart and direct relaxant effect on vascular smooth muscle which leads to \_\_\_\_ (helps increase \_\_\_\_)
positive….vasodilation
milrinone lactate is for ____ management and those who do not respond well to other meds.
short-term
Miltrinone only give through ____ –> 0.375 - 0.75 mcg/kg/min
IV
Check apical pulse for one minute before administering Digoxin/Digitoxin and do not give if pulse rate is less than ____ bpm.
60…
Monitor serum digoxin levels:
normal range –> ____ mg/mL
toxic –> ____ mg/mL
0.8 - 2… greater than 2
Monitor serum potassium levels (Normal range: ____)
Report ____.
3.5 - 5.3 mEq/L… hypokalemia
Instruct client how to check pulse rate when taking Digoxin/Digitoxin.
SEE OTHER SIDE
Report side effects to health care provider:
Low ____
n/v, ____, ____ disturbances
pulse rate… HA… visual