Cardiac Drugs Flashcards
0
Q
what does sympathetically released NA or A do?
A
B1 adrenoreceptors on heart muscle cells
PKA
phosphorylation of Ltype Ca in t tubules
more Ca enters during AP
more Ca taken up & released from SR.
1
Q
what does parasympathetically released ACh act on?
A
M2 muscarinic receptors on SAN –> opens receptir operated K+ channel.
2
Q
what is the mechanism of; lidocaine, amiodarone and verapamil and what type of drugs are they?
A
block fast Na channels block repolarising K+ channel blocks L type Ca channels. antiarrythmics (reduce excitability / prolong AP & refractory peroiod).
