Cardiac Conditions Drugs

Question 1

What are the indications for aspirin?

Answer 1

Suspected ACS
C-APO

Question 2

What are the contraindications for aspirin?

Answer 2

Allergy AND/OR ADR to aspirin OR any NSAID
Bleeding OR clotting disorders
Current GI bleeding OR peptic ulcers
Patients less than 18 years of age

Question 3

What are the precautions for aspirin?

Answer 3

Possible AAA or any other condition that may require surgery
Pregnancy
History of GI bleeding or peptic ulcers
Concurrent anticoagulant therapy

Question 4

What are the side effects of aspirin?

Answer 4

Epigastric pain/discomfort
N and/or V
Gastritis
GI bleeding
NSAID induced bronchospasm

Question 5

What is the onset, duration, and half-life of aspirin?

Answer 5

10 mins
1 week
3.2 hrs

Question 6

What is the adult dose of aspirin?

Answer 6

PO: 300mg
chewed and followed by a small sip of water

Question 7

What are the indications for clopidogrel?

Answer 7

Patients with a STEMI:
- who have been accepted for pPCI
- who have received tenecteplase

Question 8

What is the adult dose of clopidogrel?

Answer 8

pPCI- PO: 600mg/8 tablets

Fibrinolysis: PO: 300mg/4 tablets

Question 9

What is the indication for enoxaparin?

Answer 9

Patients with STEMI who have been approved for fibrinolysis

Question 10

What is the adult dose of enoxaparin?

Answer 10

IV: loading dose - 30mg

SUBCUT: Maintenance dose -1mg/kg
single dose only, not to exceed 100mg
To be administered 15 mins following IV enoxaparin

Question 11

What is the indication for tenectaplase?

Answer 11

Patient with STEMI who are accepted for fibrinolysis

Question 12

What is the adult dose for tenectaplase?

Answer 12

IV:
< 60 yrs = 30mg or 6mL
> 60 - < 70 yrs = 35mg or 7mL
> 70 - < 80 yrs = 40mg or 8mL
> 80 - < 90 yrs = 45mg or 9mL
> 90 yrs = 50mg or 10mL

Question 13

What is the indication for ticagrelor?

Answer 13

Patients with STEMI who have been accepted for pPCI

Question 14

What is the adult dose for ticagrelor?

Answer 14

PO: 180mg or 2 tablets