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Finals > Cardiac Classes > Flashcards

Cardiac Classes Flashcards

1
Q

Class 1a antiarrhythmic

  • Mechanism
  • Examples
  • Uses
A

Mechanism

  • Block Myocyte Phase 0 Na+ influx (depolarisation)
  • Sodium blocker
  • Intermediate half life

Examples

  • Quinidine
  • Procainamide
  • Disopyramide

Uses

  • SVT, VT
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2
Q

Class 1b antiarrhythmic

  • Mechanism
  • Examples
  • Uses
A

Mechanism

  • Block Myocyte Phase 0 Na+ influx (depolarisation)
  • Sodium blocker
  • Fast half life/ weak

Examples

  • Lidocaine
  • Phenytoin

Uses

  • MI associated VT
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3
Q

Class 1c antiarrhythmic

  • Mechanism
  • Examples
  • Uses
A

Mechanism

  • Block Myocyte Phase 0 Na+ influx (depolarisation)
  • Sodium blocker
  • Slow half life/ strong

Examples

  • Flecainide

Uses

  • Rhythm control
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4
Q

Class 2 antiarrhythmic

  • Mechanism
  • Examples
  • Uses
A

Mechanism

  • Block sympathetic adrenergic input
  • Slowing Nodal Phase 0
  • B-blockers

Examples + Uses

  • Carvedilol - HF Sotalol (2+3) - 1st Rhythm control
  • Atenolol - Rate control, MI, Stable Angina (4th), SVT (3rd)
  • Bisoprolol - Stable Angina (4th)
  • Metoprolol - Stable Angina (4th)
  • Propanolol - Migraine prophyl
  • Last stage of hypertension
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5
Q

Class 3 antiarrhythmic

  • Mechanism
  • Examples
  • Uses
A

Mechanism

  • Block Myocyte Phase 3 K+ efflux
  • Potassium blocker

Examples + Uses

  • Sotalol (2+3) - 1st Rhythm control
  • Amiodarone - Rhythm control, 1st VT (stable)
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6
Q

Class 4 antiarrhythmic

  • Mechanism
  • Examples
  • Uses
A

Mechanism

  • Non-DHP Calcium ‘SLOW’ channels
  • Nodal Phase O (-ve chronotrope)
  • Myocyte Phase 2 (-ve inotrope)

Examples + Uses

  • Rate control (Diltiazem> Verapamil)
  • SVT(2nd)/ asthmatic (Verapamil)
  • Angina 4th (Diltiazem, Verapamil)
  • Angina 5th Duo (DHP: Nifedipine mod. release + B-blocker)
  • Reynauds (Diltiazem + DHP: Nifedipine)
  • Cluster prophyl (Verapamil)

DHP CCB are not Class 4 antiarrhythmics.

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7
Q

Cardiac Glycosides

  • Mechanism
  • Examples
  • Uses
A

Mechanism

  1. ++Parasympathetic to SA node (-chronotrope)
  2. ++NaCa exchange, increasing intracellular Ca and force of contraction (+inotrope)

Example + Use

  • Digoxin - Rate control(2)
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8
Q

Adenosine

  • Mechanism
  • Uses
A

Mechanism

  • Opens Nodal K+ INFLUX -> HyPERpolarisation
  • Short half life
  • C: Total stop

Uses

  • Narrow Complex Tachy/ SVTs (stable)
    • (asthmatic: Verapamil)
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9
Q

Magnesium Sulphate Indications

A

MgSO4 uses

  • Torsades de Pointes
  • Hypomagnesium
  • Asthma: Severe Exacerbation
  • Pre-Eclampsia: Severe/ neuro signs
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10
Q

Magnesium Sulphate

  • Signs of Toxicity
  • Management of Toxicity
A

Toxicity Signs

  • Loss of reflexes ← Monitor every 4-6hrs
  • Flushing
  • Double vision
  • Slurred speech

Treatment

  • Stop MgSO4 infusion
  • Calcium gluconate → relieves vascular spasm
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11
Q

Atropine

  • Mechanism
  • Uses
A

Mechanism

  • Anti-muscarinic Inhibits parasympathetic input to NODES

Uses

  • Bradycardia

IM/SC - initial M1 presynaptic block prevents reuptake⇒ bradycardia

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Finals (23 decks)

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