Cardiac Arrhythmias Flashcards
arrhythmias
What is the cause?
abnormal heart rhytms
altered impulse formation, impulse conduction or both
bradycardias
It has ______ (increase/decrease) firing rate
slow heart rhythms
decreased
tachycaridas
It has _________ (decrease/increase) firing rate
fast heart rhytms
increased
What are the factors cause the altered impulse formation in tachycardias?
increase automaticity of SA node & of latent pacemakers
automaticity of atrial/ ventricular myocytes
triggered activity
What are the factors cause the altered impulse formation in bradycardias?
decrease automaticity of SA node
What are the factors cause the altered impulse conduction in tachycardias?
What are the factors cause the altered impulse formation in bradycardias?
unidirectional block & reentry
conduction block
T/F: In normal conditions, only SA node cells are able to depolarize itself to threshold
False.
AV node, Bundle of His & Purkinje fibers cells can also depolarize itself
Why does triggered activity lead to the tachycaridas?
some action potentials can trigger abnormal depolarizations that result in extra heart beats or rapid arrhythmias
T/F: cardiac tissue damage can cause myocytes outside the specialized conduction system to acquire automaticity
True
Which pacemaker cells have the fastest firing rate? 2nd & 3rd?
SA node > AV node & Bundle of His > Purkinje fibers
Describe the cells depolarization & repolarization
1) phase 4 depolarization: the Na+ channels slowly open
2) phase 0: progressive decline in K+ efflux & Na+ channels is inactive while Ca2+ slowly influx
3) K+ efflux progressively while Ca2+ channels slowly closes
What are factors that determine firing rates?
slope of phase 4 depolarization
the maximum negative diastolic potential
the threshold potential
the rate of pacemaker current (If) is equivalent to ___________
What does If depend on?
the slope of phase 4 depolarization
the # and kinetics of individual pacemaker channels through the current flows
The more negative MDP (maximum diastolic potential), the _______ firing rate as the slop of phase 4 depolarization _________ (less steeper/ more steeper)
longer
less steeper
The less negative threshold potential, the ______ firing rate as the slope of phase 4 depolarization is ________ (longer/shorter)
longer
longer
What modulate SA node?
sympathetic nervous system
Why do we say that SA node is a native pacemaker?
Because it has the highest firing rate -> set the HR
True/False: Automaticity of SA node can increase under exercise or emotional stress
True
Through what cells receptors does sympathetic system stimulate SA node?
what are hormones that these receptors react with?
ß-adrenergic receptors
epinephrine or norepinephrines
What are two factors of firing rate depends on that sympathetic stimulation affect?
steeper the slope of phase 4 depolarization
shift threshold to more negative values
What are the factors of firing rate depends on that parasympathetic system affect?
shifts maximum negative diastolic potential (MDP) is more negative
decreases the slope of phase 4 depolarization