Cardiac Amyloidosis Imaging

Question 1

what is the purpose of the cardiac amyloidosis imaging?

Answer 1

to detect and determine the type of amyloidosis present in cardiac tissues

Question 2

what are amyloidosis?

Answer 2

group of disease describing clumps of amyloids (protein) build-ups in systemic tissues

Question 3

cardiac amyloidosis aka?

Answer 3

stiff heart syndrome

Question 4

stiff heart syndrome

Answer 4

when amyloid deposits take the place of normal myocardium causing electrical signals to be affected - arrhythmias

Question 5

2 main types of amyloidosis in cardiac?

Answer 5

1. transthyretin (ATTR/TTR)
2. light chain (AL)

Question 6

ROI are drawn on what view? and where?

Answer 6

ANT planar image, over heart and over same area of the right side of the chest

Question 7

what is the H:CLC ratio?

Answer 7

heart to contralateral chest ratio - heart mean counts/pixel divided by contralateral mean counts/pixel

Question 8

visual score of 0 =

Answer 8

myocardial uptake absent

Question 9

visual score of 1 =

Answer 9

myocardial uptake greater in ribs

Question 10

visual score of 2 =

Answer 10

myocardial uptake equal to ribs

Question 11

visual score of 3 =

Answer 11

myocardial uptake great than in ribs

Question 12

normal images have a visual score of? H:CLC ratio of?

Answer 12

visual score of 0
H:CLC = equal to or less than 1.0

Question 13

should there be uptake of PYP in the myocardium?

Answer 13

no, the more activity in the heart, the worse the prognosis is for the patient

Question 14

AL amyloid will have a H:CLC ratio of?

Answer 14

1.0 < H:CLC < 1.3

Question 15

ATTR amyloid will have a H:CLC ratio of?

Answer 15

> 1.3

Question 16

which amyloid has less uptake of PYP?

Answer 16

AL