Cardiac amyloidosis Flashcards
1
Q
most commonly…
A
restrictive cardiomyopathy w/ impaired compliance
2
Q
Cause
A
deposition of amyloid in interstitium of heart
3
Q
epidemiology
A
older adults
4
Q
Senile amyloidosis
A
transthyretin deposition commonly limited to heart
familial
autosomal dominant
AA
5
Q
gross pathology
A
heart is
- -enlarged,
- -firm,
- -tan,
- -waxy
6
Q
microscopic pathology
A
interstitial deposits of hyaline smooth eosinophilic material initially perivascular
…Congo red stain!!
7
Q
complications
A
HF
heart block
arrhythmias
8
Q
symptoms
A
exercise intolerance
fatigue
dyspnea
9
Q
signs
A
JVD increased w/ inspiration (Kussmaul’s sign!)
peripheral edema
ascites
enlarged tender liver
rales
10
Q
diagnosis
A
biopsy
11
Q
treatment
A
transplantation and try to prevent recurrence
12
Q
Common presentation:
A
older adult w/ HF
