Carcinoid Syndrome Flashcards

1
Q

Definition of carcinoid syndrome?

A

Constellation of symptoms caused by systemic release of humoral factors from carcinoid tumours

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2
Q

What humoral factors are commonly secreted by carcinoid tumours?

A

Serotonin
HIstamine
Tachykinins
Prostaglandins

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3
Q

Common sites for carcinoid tumours?

A

Appendix

Rectum

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4
Q

Presentation of carcinoid syndrome?

A
Paroxysmal flushing
Diarrhoea
Cramping abdominal pain
Wheeze
Sweating
Palpitations
(think about what the humoral factors released will cause e.g. tachykinins causing palpitations/tachycardia)
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5
Q

Investigations appropriate in suspected carcinoid syndrome?

A

24 hour urine collection (looking for elevated 5-HIAA levels = serotonin metabolite)
CT/MRI to localise tumour
Worth looking for underlying MEN if additional endocrine symptoms present (systemic malignant symptoms likely to already be present)

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