Carcinogenic Genes

Question 1

SIS

Answer 1

proto-oncogene
over-expression
^ GF expr (PDGF)
(X) astrocytoma
(X) osteosarcoma

Question 2

ERB-B2

Answer 2

proto-oncogene
amplify
^ expr of HER2/Neu GF-R
(X) breast, ovary CA

Question 3

cKIT

Answer 3

proto-oncogene
pt mutation
tyrosine kinase*
(X) GI stromal tumor (GIST)

Question 4

RAS

Answer 4

proto-oncogene
pt mutation
reduced GTPase activity
(X) 15-20% ALL CA
(X) pancreas, lung

Question 5

ABL

Answer 5

proto-oncogene
translocation t(9;22)
brc;abl–> tyrosine kinase
(X) CML, ALL

Question 6

MYC

Answer 6

proto-oncogene
translocation t(8;14) or amplify
IgH:myc--> ^ transcrip
(X) Burkitt lymphoma (cMyc)
(X) neuroblastoma (nMyc)

Question 7

Cyclin D1

Answer 7

proto-oncogene
translocation t(11;14)
IgH:cyclinD= ^ cyclinD= ^ cell prolif
(X) mantle cell lymphome

Question 8

APC/B- catenin

Answer 8

tumor suppressor
mutation
^ B catenin:TCF> ^ GF
(X) FAP- Familial Adenomatous Polyposis
(X) GI and pancreatic CA

Question 9

Rb

Answer 9

tumor suppressor
mutation
E2F(TF)**= unregulated cell growth
(X) retinoblastoma
(X) osteosarcoma

Question 10

P53

Answer 10

tumor suppressor
mutation
1. no cell cycle arrest
2. no apoptosis 
(X) Li-fraumeni- inherited p53mut

Question 11

BCl2

Answer 11

Anti-apoptotic
Translocation t(14;18)
IgH;Bcl2= ^ Bcl2--/apoptosis
(X) lymphoma
SLOW grow