Bone Drugs Flashcards
Calcitonin
Anti-resorptive
(X) Osteoporosis
Bisphosphate
Anti-resorptive
(X) Osteoporosis
Indomethacin
NSAID
(X) Gout sxs- wi 24 hrs
(-) GI bleeding
(O) peptic ulcer
Naproxen
NSAID
(X) Gout sxs wi 24 hrs
(-) GI bleeding
(O) peptic ulcer
Glucocorticoid
Corticosteroid
PREDNISONE
Anti-inflammmatory Steroid
–/transcrip to–/T cell activation and IL2 prod
–/PG formation
(X) Gout sxs - short term
for pt who can’t take NSAID
(!) single dose/short course- NO harmful SE
Colchicine
G1 anti-mitotic--/microtubule of Neut --/neutrophil activation/migr (X1) Acute Gout (X2) Prophylactic chronic -oral admin, rapid abs (distrib to tubulin) (!) CYP3A4 and Pgp export (-) Narrow window: GI sxs (O) hepatic, renal disease -elderly pts,
Allopurinol
Xanthine Oxidase (red) Inhibitor–/uric acid biosynth
(!) analog of hypoxanthine->oxypurinol*
(X) Gout prophylaxis
(-) hypersensitivity
- acute gout attack - mobilized uric acid stores (use + colchicine or NSAID)
(O) Azothioprine, Mercaptopurine
Febuxostat
Xanthine Oxidase Inhibitor–/uric acid biosynth
non-purine–/ox and red XO
(X) Gout prophylaxis
(+)more potent, pt w impaired renal funct
(-) CV side effects ,dizziness, GI,
Probenacid
Uricosuric Agent- ^ UA excr --/OAT/URAT1 reabsorber (X) Gout prophylaxis, chronic gout - oral admin, dose-dep t 1/2 (-) GI side effects (O) renal insufficiency, uric acid kidney stones
Pegloticase
Uricase analog: inactivate uric acid > allantoin (X) Refractory Chronic Gout - IV every 2 weeks (-) infusion site rxn gout flare immune response to PEG
Etanercept
DMARD, BRM TNFalpha (soluble)inhibitor: recombinant fusion protein (X1) mod-severe RA (X2) juvenile RA (X3) early stage RA -IV, subQ, slow onset, elim (-1) injection site rxn (-2)^ risk of infection (-3) lymphoma in children (O) immunosuppressed, TB
Infliximab
anti-TNFalpha (tm and s) IgG monoclonal Ab (all human) (X1) mod,sever RA (+ MTX) (X2) juvenile RA (+MTX) subQ admin every other week (-1) injection site rxn (-2)^ risk of infection (-3) lymphoma in children (O) immunosuppressed, TB
Adalimumab
anti TNF-alpha (tm and s): IgG monoclonal Ab (all human) (X1) mod,sever RA (+ MTX) (X2) juvenile RA (+MTX) subQ admin every other week (-1) injection site rxn (-2)^ risk of infection (-3) lymphoma in children (O) immunosuppressed, TB
Tocilizumab
anti-l IL-6 (sol and tm): humanized
(X) ADULT pt mod,severe RA
IV admin every 4 weeks/ subQ every other day
(-) injection site rxn
(-) ^ risk of infection
(-) ^ in lipids:cholesterol, TG, LDL, and HDL
Tofacitinib
anti-Janus Kinase (JAK)
–/cytokine/GF gene expr
(X) mod, severe RA w inadeq resp to MTX
-ORAL
(!) detox via: CYP3A4 with minor CYP2C19
(-) ^ risk of infection
(-) ^ in lipids:cholesterol, TG, LDL, and HDL
