Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PathoPhys-FPP > Anti-Neoplastic Drugs > Flashcards

Anti-Neoplastic Drugs Flashcards

1
Q

Cyclophosphamide

A 
Alkylating, Class III (specific, non phase)
pro-drug w wide spectrum
(-) GI
limited myelosup
alopecia
bladder toxicity (acrolein)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Mechlorethamine

A 
alkylating, Class I (non-specif)
(X) Hodkin's, Non-Hodgkin's
(X) Breast, ovarian,lung
(-) GI
myelosupp
mild alopecia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Carmustine

A 
alkylating 
*cross BBB
(X) brain tumor, multiple myeloma, melanoma
(-) GI
delayed myelosupp
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Procarbazine

A 
atypical alkylating (G1, S)
methylation of DNA
(X) Hodgkin's lymphoma
(-) GI
myelosupp
**2o malignancy
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Methotrexate

A 
Anti-metabolite: anti-folate
bind DHFR--/THF production
(!) rescue with leucovorin (folinic acid) 
(X) acute lymphocytic leukemia
(X) choriocarcinoma
(-) intestinal epi damage
bone marrow supp
renal tube necrosis
displaced drugs from Albumin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Fluorouracil

A 
anti-metabolite: pyrimidine analog
FUTP--/RNA
FdUMP--/thymidylate synthase--/DNA
(X) GI CA
(X) bladder
(X) ovary, breast, neck
(-) GI + anorexia
myelosupp
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Cytarabine

A 
anti-metabolite: pyrimidine analog 
cytidine competition- chain termination
(X) acute leukemia -AML
(-) myelosuppression
neurotoxicity
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Mercaptopurine

A 
anti-metabolite: purine analog
--/RNA and DNA synth
(!) TPMT polymorphism- reduced metabolism= ^ toxic
(X) acute leukemia
(-) BM suppression
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Hydroxyurea

A 
Misc. Anti-neo: G1/S interface
block r-NT> dNTP==/DNA synth
\+ radiation
(X) granulocytic leukemia
(-) GI sxs
hemato depr
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Vincristine

A 
Natural agents- M phase
bind tubulin--/microtub and mitotic spindle formation
(X) acute lymphocytic anemia
(X) lymphoma
(X) neuroblastoma
(-) alopecia
NMJ abn- periph neurop
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Vinblastine

A 
natural agent- M phase
bind tubulin--/microtub and mitotic spindle formation
(X) lymphoma
(X) breast CA 
(-) myelosuppressive (dose-limiting)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Paclitaxel

A

Natural agent- G2/M phase
bind B-tubulin- ^^ assembly and stability
(X) radiosensitizer- refraf ovarian cancer
+ cisplatin- breast CA
(-) leukopenia
periph neuropathy
myalgia/arthralgia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Etoposide

A 
Natural agent- G2/M phase
DNA topoisom II--/dsDNA break repair
(X) Lymphoma, acute leukemia
small lung
testis
(-) GI sxs
leukopenia
alopecia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Doxorubicin

A 
Natural- Abx- non-phase specif
anti-angiogenic 
1. distort DNA helix
2. lipid peroxidation, ROS
3. bind DNA + topo-II
(X) lymphoma
(X) breast, ovary CA
(X) small cell lung 
(-) cardiomyopathy
BM depr, alopecia
GI sxs
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Bleomycin

A 
Natural Product Abx- G2/M
iron-chelating glycopeptide
oxidative 
(X) germ cell tumors (testes, ovary)
(X) head, neck, lung lymphoma
(-) pulmonary toxicity
skin 
hyper-pigmentation 
(lung, skin have little bleomycin hydrolase)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Trastuzumab

A 
Natural product-monoAb-
--/HER2+-R= block prolif of cells
(X) metastatic breast CA 
\+ Paclitaxel 
(-) cardiomyopathy
hypersensitivity
17
Q

Filgrastim

A

Natural product- BRM
(X) limit chemotx-induced neutropenia
-promote progen of neutrophils = ^ pop of neutrophils
(-) bone pain

18
Q

Cisplatin

A 
Natural Product- Class III
platinum DNA crossplinks 
--/ thioredoxin reductase (TrxR) 
^ apoptosis
(X) testicular CA
cisplatin + etoposide + bleomycin
(X) ovarian cancer
cisplatin + paclitaxel 
(-) nephrotoxicity
ototoxicity
peripheral neuropathy 
electrolyte disturbances
19
Q

Prednisone

A

Hormone-Steroid
bind steroid R–/growth genes
–>*nuclease> cell lysis
(X) leukemia, lymphoma
(+) anti-emetic, appetite stim, anti-inflamm
(-) immuno/myelosupp, wt gain, fluid retention, psych effect

20
Q

Tamoxifen

A 
Hormone- anti-estrogen
CYP2D6> TAM*= ^ sex hormone binding globulin
(X) adv post-men BC
metastatic pre-men BC
BC prophylaxis
(-) CYP2D6 ultrametab= & SE
hot flash, fatigue, 
bone, musc-sk pain
^ risk of uterine/endometrial CA
21
Q

Letrozole

A 
Hormone- anti-estrogen
Aromatase(CYP19) inhibitor 
(X) metastatic post-men BC
(+) oral, rapid onset w NO androgenic SE
(-) hot flash, fatigue
bone, musc-sk pain
loss of bone, mineral density
22
Q

Leuprolide

A 
Hormone- anti-testosterone
GnRH analog= ^ LH, FSH, then sudden drop!
(X) 1st line prostate CA
--monthly subQ inject/implant
(-) hot flashes, impotence
23
Q

Flutamide

A 
Hormone- anti-testosterone 
Ar-R blocker
(X) 2nd line metastatic prostate CA
\+ GnRH agonist (Leuprolide) 
(-) gynecomastia, diarrhea
hepatotoxic

PathoPhys-FPP (5 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions