Carbohydrates Flashcards
What are the insulin independent transporters?
GLUT 1, GLUT 2, GLUT 3
What is the insulin dependent transporter?
GLUT 4
Normal blood glucose levels?
4-6 mM
Converts glucose into 2 pyruvate
Glycolysis
Where does glycolysis occur?
Cytosol
What regulates glycolysis?
- Glucose transport
- Glucokinase
- Phosphofructokinase-1
- Pyruvate kinase
What is: a complex polymer of glucose molecules?
Glycogen
Glycogen is the stored form of what and where?
Glucose, in liver and muscle.
The synthesis of glycogen
Glycogenesis
Regulations of glycogenesis?
Glucose transport & glycogen synthase
The breakdown of glycogen
Glycogenolysis
Regulation of glycogenolysis?
Glycogen phosphorylase
Biosynthesis of glucose
Gluconeogenesis
The function of gluconneogenesis?
Maintenance of blood glucose
Precursors of gluconeogensis?
Lactate, glycerol, and amino acids.
Regulations of gluconeogenesis?
- Pyruvate carboxylase
- Phosphoenolpyruvate carboxykinase
- Fructose 1,6-bisphosphatase
- Glucose 6-phosphatase
Normal blood glucose levels?
4.5-5.5 molecules/L
After a meal blood glucose levels?
6.5-7.2 mmol/L
Starvation blood glucose levels?
3.3-3.9 mmol/L
Where does blood glucose come from?
- Dietary carbohydrates
- Liver glycogen
- Gluconeogenesis
Regulations of blood glucose?
- Transport
- Glucokinase
Fate of pyruvate can be what? (3 options)
- Fatty acid synthesis
- Lactate
- Citric acid cycle
Oxidation of acetyl-CoA resulting in formation of ATP
Citric acid cycle
True of false: The Citric acid cycle is aerobic.
True
Regulations of the Citric Acid cycle?
- Pyruvate dehydrogenase
- Isocitrate dehydrogenase
Steps of the Citric Acid cycle?
**Pyruvate dehydrogenase —-> Acetyl CoA
1. Acetyl CoA to citrate
2. Citrate to isocitrate
3. Isocritrate to a-ketoglutarate
4. A-ketoglutarate to succinyl-CoA
5. Succinyl-CoA to succinate
6. Succinate to Fumarate
7. Fumarate to malate
8. Malate to Oxaloacetate— start over
Glycolysis steps?
Glucose
Glucose-6- Phosphate
Fructose-6- Phosphate
Fructose-1,6-Biphosphate
DHAP
GLAP
1-3 Biphophoglycerate
3-Phosphoglycerate
2-Phosphoglycerate
Phosphenol pyruvate
Pyruvate