Carbapenems Flashcards

1
Q

CARBAPENEMICOS

A

Compuestos biciclicoa b-lactamicos con un anillo común= Carbapemen

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2
Q

Carbapenemasas que afectan a los Carbapenems

A
  • P. aeruginosa
  • Acinetobacter Baumani
  • Enterobacterias
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3
Q

Tipos de Carbapenemasas

A

A- KPC
B- Metalo b-lactamasas
C- OXA-48

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4
Q

Mecanismos de resistencia de Carbapenems

A
  • Alteración en PBP (SARM)

* Modificación de porinas (Pseudomonas)

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5
Q

Carbapenemasas A

KPC

A

Las inhibe:
•Ácido Clavilanico
•Ácido borónico

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6
Q

Carbapenemasas B

MBL

A

EDTA- Las inhibe

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7
Q

Carbapenemasas C

OXA-48

A

No hidrolizan cefalosporinas

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8
Q

Nombres de Carbapenems

A
  • Imipenem-Cilastatina
  • Meropenem
  • Ertapenem
  • Doripenem
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9
Q

IMIPENEM-CILASTATINA

Espectro

A
  • Acinetobacter
  • Enterococus faecalis
  • P. Aeruginosa
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10
Q

MEROPENEM

Espectro

A
  • HIB
  • Enterobacterias
  • P. Aeruginosa
  • Acinetobacter
  • E. Faecalis
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11
Q

ERTAPENEM

Espectro

A
  • SASM
  • Estrepto
  • Enterobacterias
  • HIB
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12
Q

DORIPENEM

Espectro

A

P. Aeruginosa

+ potente que imipenem y meropenem

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13
Q

Carbapenem que no funciona con P. Aeruginosa

A

ERTAPENEM

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