Capillary Filtration Flashcards

1
Q

features of capillaries

A

0.5-1mm long
5-8µ in diameter
0.2µ thick
allow for mass exchange of materials

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2
Q

pressure and flow of capillaries

A

32cm H20 at arterial end
22cm H20 at venous end
average flow velocity 700mm/sec
average transit time 0.25 - 2 seconds

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3
Q

what makes up capillary structure

A

endothelial tube
vacuoles
intercellular junctions
pericytes

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4
Q

2 types of capillary junctions

A

Gap/tight junctions

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5
Q

mechanisms of transport in endothelial cell

A

O2/CO2/solutes - diffusion
water - filtration
macromolecules - transcytosis(similar to active transport)

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6
Q

endothelial glycocalyx

A

fibrillar glycoproteins
cover intellectual gaps
important to capillary filtration

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7
Q

determinants of capillary filtration(starling forces)

A

balance of osmotic and hydrostatic pressure

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8
Q

how does venous pressure lead to swelling

A

increase venous pressure
increased hydrostatic capillary pressure
increases fluid filtration rate
tissue swells

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9
Q

revised model of forces on cell

A

hydrostatic capillary pressure opposed by interstitial pressure which is opposed by osmotic pressure exerted by endothelial glycocalyx

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10
Q

Starling equation

A

Jv = Lp .A .[(Pc- Pi) – σ(Π𝑖−Π𝑔)]
Jv: Fluid Filtration Rate
Lp: Hydraulic Conductivity
A: Capillary surface area
Pc: Hydrostatic Capillary Pressure
Pi: Hydrostatic pressure in the interstitium
Π𝑝: Plasma colloid osmotic pressure
Π𝑔: Glycocalyx osmotic pressure
σ: Reflection coefficient

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11
Q

reflection coefficient

A

how likely it is larger molecules cant make it through gap in glycocalyx

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12
Q

hydraulic conductivity

A

is affected by number of open endothelial junctions, size of intellectual cleft gaps, permeability of glycocalyx

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13
Q

oedma

A

swelling of tissue
fluid accumulates in tissue
caused by increased venous pressure NOT arteriolar

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