Capillaries I Flashcards

Solute exchange

1
Q

Functions of cell membranes [4 marks]

A
  • Provide support and protection
  • Cell-to-cell recognition
  • Regulates entry/exit of substances to and from the cell
  • Regulates cell function
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2
Q

What is passive transport? [2 marks]

A
  • Movement DOWN a gradient

- Doesn’t require energy

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3
Q

What is active transport? [2 marks]

A
  • Movement AGAINST a gradient

- Requires energy

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4
Q

What gradient does diffusion go through? [1 mark]

A

Concentration

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5
Q

What gradient does convection go through? [1 mark]

A

Pressure

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6
Q

What gradient does osmosis go through? [1 mark]

A

Osmotic pressure

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7
Q

What gradient does electrochemical flux go through? [1 mark]

A

Electrical & concentration

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8
Q

What does the concept of permeability include? [3 marks]

A
  • Passive diffusion properties (e.g. conc, rate)
  • Solute and membrane properties (e.g. Fick’s law)
  • Capillaries properties
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9
Q

What is the formula for time taken to move a specific distance for diffusion? [4 marks]

A

time = (net distance)^2/2 x diffusion coefficent

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10
Q

What properties of the solute affect transport? [3 marks]

A
  • Concentration gradient
  • Size of solute
  • Lipid solubility
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11
Q

What properties of the membrane affect transport? [4 marks]

A
  • Membrane thickness/composition
  • Aqueous pores
  • Carriers
  • Active transport mechanisms
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12
Q

What does Fick’s law consider? [1 mark]

A

Properties of solutes and membranes affecting transport

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13
Q

What factors determine Fick’s law? [4 marks]

A
  • Diffusion coefficient
  • Area that solute diffuses through
  • Concentration gradient
  • Distance between point A and B
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14
Q

What is the diffusion coefficient? [1 mark]

A

How easily a solute can move through the solvent

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15
Q

What are the structure of continuous capillaries? [2 marks]

A
  • Continuous basement membrane

- Tight junctions between epithelial cells

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16
Q

What are the structure of fenestrated capillaries? [2 marks]

A
  • Disruption of membrane

- Fenestrated structures

17
Q

What are the structure of discontinuous capillaries? [2 marks]

A
  • Very large fenestrated structures

- Disrupted membrane

18
Q

What are structures of capillaries that can affect solute transfer? [4 marks]

A
  • Fibrous basement membrane
  • Caveolae and vesicles
  • Intercellular clefts
  • Glycocalyx
19
Q

What is the glycocalyx? [2 marks]

A
  • Negatively charged carbohydrates

- Dynamic barrier that covers endothelium and blocks solute permeation

20
Q

What is permeability? [2 marks]

A
  • The rate of solute transfer by diffusion across unit area of membrane per unit concentration difference
  • How freely a solute crosses a membrane
21
Q

How does a porous membrane interfere with diffusion of lipid insoluble solute? [3 marks]

A
  • Reduce area for diffusion
  • Increases path length through membrane
  • Restricted diffusion in pore produces hydrostatic issues
22
Q

What is the formula for Fick’s law? [4 marks]

A

Rate of solute transport = Permeability x Area available for membrane x concentration gradient