Cannabinoids

Question 1

define cannabis

Answer 1

plant based only

Question 2

define cannabinoids

Answer 2

anything that acts on CB receptors- can include nonplants

Question 3

T or F: cannabis has mostly been approved based on low quality evidence, anecdotal reports, individual testimonials, and public opinion

Answer 3

T

Question 4

cannabis is a genus of ___________

Answer 4

flowering plant in the family cannabaceae

Question 5

T or F: C. sativa is more studied and less variable

Answer 5

F- highly variable

Question 6

what is the most abundant GPCR in the CNS

Answer 6

CB1

Question 7

CB1 inhibits NT by

Answer 7

inhibition of voltage gated Ca2+ channels and reversing K+ channels

Question 8

which receptor regulates neuronal growth and synapse formation

Answer 8

CB1

Question 9

CB1 receptor effects

Answer 9

modulates pain perception, mood, anxiety, satiety, hormonal control, and voluntary motor control

Question 10

CB2 is expressed on

Answer 10

glia and immunomod cells throughout body

Question 11

CB2 receptor effect

Answer 11

activation limits cell migration and release of proinflammatory stimuli = limits inflammatory response

Question 12

what is the most studied component of cannabis

Answer 12

THC

Question 13

THC is _____ active and a ____ agonist at CB1 and 2

Answer 13

psychlogically
partial

Question 14

CBD is considered _______ and has _____ at CB1 and 2

Answer 14

nonpsychoactive
weak antagonism at CB1 and 2

Question 15

besides CB1 and 2, does CBD bind to anything else?

Answer 15

orphan GPCR55, 5HT1A

Question 16

what may inhibit endocannabinoid (anamdamide) uptake and metabolism?

Answer 16

CBD

Question 17

4 indications cannabinoids may be effective for

Answer 17

prevention of chemo induced nausea and vomiting
decreasing spasticity of MS and spinal cord injury
preventing seizures in Lennox-Gastaut and Dravet syndrome (CBD)
decreasing pain in chronic neuropathic pain

Question 18

_______ had the most robust data for pain

Answer 18

nabiximols

Question 19

how were cannabinoids compared against other analgesics in studies?

Answer 19

placebo vs cannabinoids being added to stable doses of analgesics

Question 20

T or F: higher doses of cannabinoids produce higher analgesic effects

Answer 20

F- just cause more AEs

Question 21

T or F: THC content used in studies is generally higher than whawt is currently available

Answer 21

F- much lower

Question 22

effect of cannabis use in pregnancy

Answer 22

lower birth weight
preterm/stillbirth
negative effect on neurodevelopment

Question 23

cannabis effect on lactation

Answer 23

does transfer into breastmilk = effect on neurodevelopment

Question 24

to classify as cannabinoid hyperemesis syndrome, the pt must use it for

Answer 24

more than one year, at least weekly

Question 25

CHS is characterized by

Answer 25

severe N/V, resolutin of sx after stopping cannabinoid, compulsive hot bathing/ showering for symptomatic relief

Question 26

tx for CHS

Answer 26

stop cannabinoid
supportive measures
capsacin cream

Question 27

THC is a CYP_______ substrate

Answer 27

2C9 and 3A4

Question 28

CBD is a ____ inhibitor and substrate and a ___ substrate

Answer 28

2C19
3A4

Question 29

smoking cannabis may reuslt in _____ induction

Answer 29

CYp1A2

Question 30

drug interactions with cannabis

Answer 30

ethanol, opioids, BZs, anticholinergics