ADHD Flashcards

1
Q

Essential feature of ADHD is a persistent pattern of _______- impulsivity that interferes with functioning and development

A

inattention and/or hyperactivity

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2
Q

ADHD is
1. often changing once in adulthood
2. more often diagnosed in adulthood
3. a chronic, lifelong condition
4. a neurodevelopmental disorder
5. 3+4
6. all of the above

A

5

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3
Q

____% of those diagnosed in childhood continue to have significant sx in adult life

A

50

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4
Q

what is the prevalence hap between M and F in ADHD

A

M higher, but gap is shrinking
F tend to have inattentive ADHD which is harder to catch

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5
Q

which of the following is false
1. 70% school aged children with ADHD have at least 2 other psychiatric condition
2. those with ADHD are more likely to have an intellectual disability
3. tends to come with anxiety and depression in adulthood
4. stimulants in adulthood are protective against substance use disorder

A

1- 1 other psyc condtiion

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6
Q

describe inattentive ADHD

A

wandering of task, lacking persistence, difficulty sustaining focus, and disorganization not due to defiance or lack of comprehension

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7
Q

describe hyperactive/ impulsivity in adhd

A

excess motor activity when it is not appropriate (excessive fidgeting, tapping, talkativeness)/ hasty actions that occur in the moment without forethought + have high potential to harm that individual- desire for immediate rewards or inability to delay gratification

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8
Q

list the 3 types of ADHD

A

inattentive
hyperactive
combined

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9
Q

what are the 6 diagnostic criteria of ADHD

A

Meets 6 or more of sx criteria (if >17yrs old only req 5)
Present for last 6 mths
Sx interfere with functioning or development
Several sx present prior to 12yrs old
Sx present in 2 or more settings (home/ school)
Sx not explained by another mental disorder, and do not occur exclusively during the course of another psychotic disorder

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10
Q

how many points does one need from either the A1 or A2 category to get an inattentive or hyperactive ADHD diagnosis if they’re under 17? what if they’re older than 17?

A

6/9 on A1 or 6/9 on A2
5/9 if >17yrs old

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11
Q

what is typically the natural hx of ADHD

A

Hyperactivity predominant → inattention predominant → inattention and impulsivity predominant

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12
Q

describe mild ADHD

A

few, if any sx in excess of those required to make a dx are present +sx result in no more than minor impairment in social/ occupational function

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13
Q

describe moderate ADHD

A

ADHD that is not mild or severe, but in between

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14
Q

describe severe ADHD

A

many sx in excess fo those required for dx, or several that are severe, or the sx result in significant impairment in social/ occupational functioning

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15
Q

list the 3 categories of RF for ADHD

A

genetics
environment
temperament

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16
Q

what are 2 temperament descriptors for ADHD

A

reduced behavioral inhibition, novelty seeking

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17
Q

what are some environmental RF for ADHD

A

v low birth weight (but most do not develop ADHD), childhood trauma, neurological infections, EtOH/ substances during pregnancy, toxins (ex- lead)

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18
Q

describe genetic risks for ADHD

A

heritable, elevated risk for 1st degree relatives who have ADHD, no causal genes identified

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19
Q

describe the 2 points for pathophys of ADHD

A

altered brain anatomy
NT dysregulation

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20
Q

describe the NT dysregulation of ADHD

A

low tonic pool of DA and NE = not enough negative feedback to presynaptic neuron = neuron doesn’t know what to do if burst
when a burst happens = no negative feedback = DA/NE overwhelms the postsynaptic receptors = impaired attention and hyperactivity

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21
Q

how do stimulants help with NT dysregulation in ADHD

A

Stimulants reduce reuptake of DA/NE = higher baseline pool = ↑ negative feedback
when a burst happens = better able to control it as the burst amount and stimulus DA/NE amount are more similar, negative feedback not as overwhelmed

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22
Q

describe the altered brain anatomy in ADHD

A

impaired connectivity between frontal decision making parts of the brain and middle processing parts

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23
Q

what are the causal genes for ADHD

A

there are none

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24
Q

what are some nonpharm options for ADHD

A

psychoeducation
psychosocial interventions to promote success in different settings/ interactions
manualized interventions
exercise, sleep hygiene, diet

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25
which of the following is false 1. ADHD meds should be dosed by weight in children 2. caution with MP in 1st trimseter due to risk of cardiac malformations 3. MP is CI in those with FHx/ personal Hx of glaucoma 4. there is no max age for stimulants
1- not weight dosed
26
list the 4 issues that should be treated before ADHD
psychosis, severe mood disorders ,SUD, suicidality/ violence
27
name the 2 stimulants used in ADHD
amphetamines, methylphenidate
28
what is a nonstimulant used for ADHD
atomoxetine
29
alpha 2a receptor agonists for ADHD
guaifenesin, clonidine
30
1st line tx for ADHD is
long acting stimulants- methylphenidate or amphetamine based
31
pros of LA stimulants
↑adherence (comp SA), privacy, compliance, sx coverage, ↓diversion potential, rebound
32
cons of LA stimulants
cost, often not covered
33
if a pt has trialed vyvanse and failed, what should be next line?
another LA stimulant- either an amphetamine or methylphenidate trial at least 2
34
2nd line tx for ADHD
Short/ intermediate acting stimulants (amphetamine or methylphenidate based) atomoxetine and guanfacine XR
35
pros for atomoxetine and guanfacine XR
low abuse potential, alternate SE profile compared to stimulants
36
cons for atomoxetine and guanfacine XR
less robust evidence, delayed onset at 6-8wks
37
what agents may be combined with a long acting stimulant for augmentation in suboptimal responders
atomoxetine and guanfacine XR
38
when should 3rd line agents be used in ADHD
CI to 1st + 2nd line not indicated in uncomplicated ADHD- would have specialist at this point
39
what are the 4 3rd line agents for ADHD
Clonidine (a2- adrenergic agonist) Bupropion (NDRI) Imipramine (TCA) Modafinil (unclear MOA- CNS stimulant, DA activity)
40
which agent is incorrectly matched with it's SE 1. atomoxetine = increased BP 2. methylphenidate = decreased appetite 3. rebound LA agents = rebound 4. guanfacine = increased HR
4 - guanfacine = decreased HR/ BP
41
how to treat ADHD rebound
Dividing daily doses into 2 tablets taken at different times to ensure they wear off over a longer period (ex- 9am + 12pm dose) Supplement with a low dose of SA stimulant to overlap end of LA
42
which of the following is a pro for drug holidays in ADHD- choose the one with the best evidence 1. avoid being shorter than peers 2. avoids exposure to SEs 3. allows for reassessment of therapy 4. 2+3 5. all of the above
4 not much evidence for growth delay
43
how to manage insomnia with ADHD
AM dosing preferred, avoid late afternoon/evening doses if possible Strict sleep schedule and sleep hygiene non pharm/ pharm measures for sleep if necessary
44
how to manage rebound hyperactivity with ADHD
May be due to wearing off of therapy Consider using LA product if not already/ supplemental IR dose
45
how to manage psychosis/ anxiety with ADHD meds
Not an absolute CI to stimulant therapy Collaborate, consider adjunct AP, AD, or stabilizing tx Titrate slowly
46
how to manage reduced appetite/ growth with ADHD meds
Dose with meals rather than before or supplement meals with boost/ ensure Schedule means to accommodate hunger Drug holidays if necessary
47
how to manage CV risk with ADHD meds
Monographs and most professional societies rec baseline ECG + cardiac eval if any hx of sx CVD- if no hx, not necessary
48
amphetamines 3 MOA
↑ release of DA and NE from presynaptic neuron, ↓ presynaptic reuptake (competitive inhib), ↑ cerebral cortex and subcortical stimulation
49
methylphenidate 2 MOA
↑ cerebral cortex stimulation + subcortical stimulation (ACC and precuneus), ↓ presynaptic reuptake of DA and NE (requires effective endogenous catecholamine release)
50
2 intermediate acting amphetamines are
dextroamphetamine (dexedrine spansules), mixed amphetamine salts (Adderall XR)
51
lisdexamphetamine onset and peak
<60min/ 3-5hrs
52
what is the longest acting crushable tablet
vyvanse
53
which ADHD med is a prodrug
Lisdexamfetamine (vyvanse)
54
amphetamines are mostly metabolized by
2D6
55
dexedrine spansules contain a mix of
50/50 of IR/CR sprinkles. Open and sprinkle if needed
56
onset/ peak of biphentin
30-60min/ 2hrs
57
Foquest onset/ peak
onset 60min peak 2, 10hrs
58
duration of foquest
16hrs
59
what is the longest acting stimulant
foquest
60
which of the following can not be crushed/ sprinkled (choose all that apply) 1. Adderall XR 2. ritalin SR 3. biphentin 4. dexedrine spansules
1, 2
61
how is methylphenidate mtabolized
deesterificatio n
62
are methylphenidate ER-C and Concerta interchangeable?
no- T max v different, pt will feel effects at different time
63
biphentin is
metylphenidate CR capsule
64
concerta is
methylphenidate CR tablet
65
atomoxetine class
nonstimulants
66
atomoxetine onset and max effect
2-4wks max effect in 6-8wks
67
atomoxetine half life
5hrs as a parent drug, 6-8hrs for metabolites
68
which can not be used in children <6yrs 1. atomoxetine 2. guaifenesin
1
69
atomoxetine caution with
SSRIs/ NDRIs that are 2D6 inhibitors like fluoxetine, paroxetine, buproprion
70
atomoxetime SEs
Insomnia, weight loss/ ↓ appetite, anxiety, incr BP/tachy, somnolence
71
guaifenesin class
Alpha 2a receptor agonists
72
guifenesin onset
4-8wks
73
which has no evidence in adults 1. atomoxetine 2. guaifenesin
2
74
what is the only agent indicated for adj treatment with stimulants
guaifenesin
75
you should not take guaifenesin with
grapefruit or fatty meals
76
guaifenesin metabolism by
CYP 3A4
77
guaifenesin SEs
Drowsiness, HA, hypotension/ bradycardia, upper abdominal pain, somnolence
78
modafinil 2 MOAs
↓DA reuptake into presynaptic terminal = ↑ DA activity Inhibits GABA NT via many effects of 5HT + receptors (GABA system often inhibits = ↓ inhibition = stimulating CNS)
79
stimulant doses should be titrated _____, and nonstimulants ____
stimulants qwk nonstimulnts q2wks
80
Can observe improvements with stimulants in _______ and nonstimulants
stimulants: days to weeks nonstimulants: wks-mths
81
what is a CI for stimulants
FHx/ Hx glaucoma