Alcohol Use Disorder Flashcards

1
Q

which of the following is true about binge drinking
1. binge drinking can have the same effect as having the same amount over a longer period of time
2. it is linked with higher rates of behaviours that put people’s health at risk
3. is never safe
4. all of the above

A

4

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2
Q

Among healthy individuals, there is a continuum of risk for alcohol related harms where the risk is
Negligible to low for individuals who consume __ standard drinks or less / wk
Mod for ____ standard drinks/wk
Increasingly high for ____ standard drinks/ wk

A

2
3-6
>6

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3
Q

On any occasion, any level of consumption has risks, and with more than ____ standard drinks, most individuals will have an increased risk of______________

A

2
injury or other problems

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4
Q

which of the following statistics is true
1. Disproportionately more injuries, violence, and deaths result from men’s drinking
2. Above low levels of alcohol consumption, the health risks increase more steeply for women than for men
3. Having <2 drinks per week is safe in breastfeeding, but is strongly recommended against
4. any level of alcohol consumption is associated with some risk

A

3

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5
Q

how often should you screen for alcohol use disorder

A

annually and with major life events

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6
Q

name 2 tools used to screen for AUD

A

CAGE
AUDIT-C

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7
Q

what are 2 pros of CAGE

A

easy Y/N questions, doesn’t require quantification of alcohol (tends to underreport)

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8
Q

what is a con for CAGE

A

less sensitive than AUDIT-C for detecting high risk drinking patterns

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9
Q

what is a con for AUDIT-C

A

may be less sensitive for specific groups like women, older adults, other ethnicities, etc

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10
Q

T or F: screening alone is enough to improve AUD outcomes

A

F

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11
Q

A variety of approaches exist for brief interventions- what is consistent is that they include a ________________

A

brief variant of motivational interviewing

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12
Q

what is the 5 A model for delivering alcohol use brief interventiosn

A

ask, advise, assess, assist, arrange

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13
Q

what is included in the “assess” piece of alcohol use brief interventions

A

is the pt willing to make a change rn

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14
Q

what is included in the “advise” piece of alcohol use brief interventions

A

advising pts in a clear, strong, and personalized manner that they may be at risk of alcohol related harms

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15
Q

define alcohol use disorder + how long the time period must be

A

a problematic pattern of alcohol use leading to clinically significant impairment or distress, as manifested by at least 2 of the designated criteria, occurring within a 12mth period

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16
Q

define the following
clinically significant problematic behavioural or psychological changes that develop during, or shortly after alcohol ingestion

A

alcohol intoxication

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17
Q

T or F: a person may have BAD of >40 but still be functional if they have been a heavy user

A

T

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18
Q

T or F: a patient may undergo alcohol withdrawal even if they still have alcohol in their blood

A

T- is a relative change

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19
Q

what would we expect to see at 5mg/dL

A

legally impaired

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20
Q

what would we expect to see at 10mg/dL

A

significantly impaired

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21
Q

what would we expect to see at 20mg/dL

A

impaired ability to walk

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22
Q

what would we expect to see at 30mg/dL

A

loss of consciousness

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23
Q

what would we expect to see at 40mg/dL

A

respiratory arrest, coma, death

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24
Q

define alcohol withdrawal

A

cessation of (or reduction in) alcohol use that has been heavy and prolonged (hangover = mild sx of alcohol withdrawal)

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25
Q

when is alcohol withdrawal expected to set in

A

48-72hrs up to 5 days

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26
Q

sx expected <6-12hrs from alcohol cessation

A

Hand tremors, N/V, mild agitation, anxiety, insomnia, HA, diaphoresis

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27
Q

sx expected 12-24hrs after alcohol cessation

A

Alcohol hallucinosis: transient tactile disturbances (pruritus, pins and needles, burning, numbness), transient auditory and visual hallucinations

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28
Q

when does alcohol hallucinosis usually resolve

A

after 48hrs

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29
Q

sx expected 24-48hrs after alcohol cessation

A

Tachycardia, HPTN, marked agitation, withdrawal seizures

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30
Q

sx expected 48-72hrs after alcohol cessation

A

delirium tremens, seizures, hallucinations, profuse diaphoresis , tachycardia, tremors

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31
Q

depending on tolerance, people can go into severe withdrawal early than ____

A

48hrs

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32
Q

if a patient has stopped alcohol 50 hours ago and has not had a seizure, is it likely that they will have one?

A

no- if >48hrs

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33
Q

T or F: alcohol withdrawal is fatal

A

T

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34
Q

how dose alcohol withdrawal result in seizures

A

With chronic alcohol use, brain and body adapts so GABA mediated systems becomes less sensitive and GLU systems become hypersensitive- sudden stop = increased sensitivity to excitation (hypersensitive glutamate system) = lowers seizure threshold

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35
Q

list 3 factors that increase withdrawal

A

seizure withdrawal, previous tremens, + hx for impatient residential tx programs, blacked out, use of other CNS depressants or illicit substances, evidence of increased autonomic activity (if HPTN + HR already high)

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36
Q

T or F: delirium tremens can be fatal

A

T

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37
Q

what are some lab liver function test findings with alcohol use disorder

A

increased GGT + increased AST, ALT, bilirubin

38
Q

lab findings of complete blood count in AUD

A

increased MCV, macrocytic anemia
lowered folate and thiamine

39
Q

electrolyte changes in AUD

A

disturbances in phosphate, potassium, magnesium

40
Q

changes in blood glucose with AUD

A

decreased BG
ketoacidosis possible

41
Q

which tool helps identify pts who may be msot at risk for developing severe alcohol withdrawal sx

A

PAWSS

42
Q

waht is a tool used to assess level of withdrawal

A

CIWA-Ar

43
Q

list 4 complications from alcohol withdrawal

A

seizures, delerium tremens, Wernicke’s encephalopathy, korsakoff’s dementia

44
Q

what is Wernicke’s encephalopathy

A

complication from alcohol withdrawal secondary to severe thiamine deficiency

45
Q

what causes wernicke’s encephalopathy

A

decreased food consumption and absorption + storage in liver = less thiamine

46
Q

sx of wernicke’s encephalopathy

A

CNS depression, wide ataxic gait, pupil abnormality, nystagmus, hemorrhage, decreased BP and temp

47
Q

sx of korsakoff’s dementia

A

persistent psychosis, confabulation, retrograde and anterograde amnesia

48
Q

T or F: most people with korsakoff’s dementia do not recover

A

T

49
Q

tx for korsakoff’s dementia

A

prevention is essential as most do not recover
AP, cholinesterase inhibitors, thiamine replacement

50
Q

how to prevent Wernicke’s encephalopathy

A

thiamine vit B1, then give glucose

51
Q

describe the pathology of Wernicke’s

A

alcohol metabolism increases demand for thiamine, but poor nutrition decreases supply = decreased coenzyme thiamine pyrophosphate required for glucose metabolism in the brain = no glucose available for brain = WK encephalopathy

52
Q

1st line for alcohol withdrawal tx

A

benzodiazepines

53
Q

3 most common BZDs used for alcohol withdrawal tx

A

lorazepam, diazepam, chlordiazepoxide

54
Q

what type of BZDs are preferred for alcohol withdrawal

A

longer acting agents for seizure prevention and less breakthrough sx

55
Q

there is an increased risk of addiction with the 3 following BZDs due to their fast onset

A

diazepam, alprazolam, lorazepam

56
Q

BZDs in alcohol withdrawal should be dosed ___

A

PRN by sx

57
Q

which BZD is preferred in elderly

A

lorazepam

58
Q

lorazepam is the preferred BZD in

A

elderly, those with respiratory depression, hepatic disease

59
Q

why is lorazepam the preferred BZD in elderly, resp dep, and hepatic disease

A

no active secondary metabolites

60
Q

T or F: BZDs in alcohol withdrawal are dosed very conservatively to avoid respiratory depression

A

F- aggressive dosing, but is still limited by sedation, confusion, and resp dep

61
Q

T or F: LDs may be used for BZDs in alcohol withdrawal

A

T

62
Q

how long is the length of BZD therapy for AW

A

usually <7d

63
Q

list the 3 on label anticraving meds for AW

A

acamprosate
naltrexone
disulfiram

64
Q

acamprosate MOA

A

may restore balance between glutamate mediated excitation and GABA mediated inhibition of neural activity + decrease neuronal hyperexcitability

65
Q

with acamprosate, there is a significant decrease in _____ and an increase in ____________ compared to placebo

A

decrease in returning to drinking
increase cumulative duration of abstinence by 11 days compared to placebo

66
Q

describe the typical dosing of acamprosate

A

333mg PO TID F3D, then increase to 666mg PO TID

67
Q

when should acamprosate be started

A

4 days after last alcohol consumption

68
Q

when should acamprosate dosing be adjusted

A

CrCL 30-50 = decrease 50%
avoid if CrCL <30
wt <60kg = use BID dosing

69
Q

can acamprosate by used in pregnancy

A

yes- must use risk /benefit analysis
not much evidence for risks, much evidence for risks of alcohol

70
Q

what is a major pro for acamprosate

A

no drug interactions

71
Q

which of the following has no drug intx
1. acamprosate
2. naltrexone
3. disulfiram
4. topiramate

A

1

72
Q

acamprosate is preferred in

A

opioid users, those not at risk of polypharmacy

73
Q

acamprosate AE

A

GI upset

74
Q

naltrexone MOA

A

mu opioid receptor antagonist that blocks euphoria associated with alcohol

75
Q

naltrexone is effective in preventing/ lowering (3)

A

relapse rates, # of drinking days, cravings,

76
Q

naltrexone is dosed
1. daily
2. PRN
3. either

A

3

77
Q

naltrexone CIs

A

acute hepatitis, severe liver dysfunction, those requiring/ taking concurrent opioids

78
Q

naltrexone SEs

A

GI upset, mood, hepatotoxicity

79
Q

naltrexone is preferred in

A

renal dysfunction, struggles with polypharmacy, nonopioid users

80
Q

disulfiram works as an

A

alcohol deterrent tx

81
Q

disulfiram MOA

A

inhibits metabolism of alcohol by blocking acetaldehyde dehydrogenase = acetaldehyde build up and causes disulfiram reaction

82
Q

how soon does the reaction start after disulfiram + how long does it last

A

can happen right after alcohol ingestion + last for several hours up to 2wks

83
Q

what are some severe reactions to disulfiram

A

MI, CHF, arrhythmias, resp dep, seizures, death

84
Q

T or F: there is no advantage of disulfiram over placebo in achieving abstinence or decreasing relapse

A

T

85
Q

disulfiram should be started at least ____ after last drink

A

36hrs

86
Q

what is important to counsel the patient on if they start disulfiram to stop alcohol

A

hidden forms of alcohol in mouthwashes, cough syrup, etc

87
Q

disulfiram SEs

A

poor after taste, dermatitis, hepatitis, N/V, HA

88
Q

what are 2 off label treatments for AW

A

gabapentin
topiramate

89
Q

how might topiramate decrease AW

A

decreases dopamine release and alcohol cravings = decreases heavy drinking days
may alter GABA function at a nonBZD site on the GABAA receptor + antagonize glutamate activity

90
Q

topiramate SEs

A

paresthesias, anorexia, pruritis, difficulty concnetrating, somnolence, fatigue, confusion

91
Q

what are managed alcohol programs? who are they targeted towards

A

provides prescribed doses of alcohol at regular intervals
done in acute care to support those in hospital where forced detox is harmful and abstinence is not a realistic ST goal while admitted
there are now also some community programs