Cancer Therapeutics Flashcards
What is the most treatable type of cancer?
Non-malignant melanoma
Why do survival rates differ between Local, Regional and Distant tumours?
Local tumours show no sign of spreading and thus if excised will result in halting of tumour progression, high survival chance.
Regional tumours that start spreading to neighbouring tissues can have good survival rates if treated after diagnosis.
Distant tumours that have spread to different sites are difficult to treat as they are spread throughout the body.
What current treatments are there for breast cancer?
Masectomy - removal of breast tissue
Chemotherapy
What is the estimated level of over-diagnosis for breast cancer?
For every 56 cases, 5 diagnosed breast cancer and saved lives, 2 overdiagnosed.
It is thought that 5-10 women undergo unnecessary surgery for each women whose life was saved by surgery.
What are the chances of a women dying from breast cancer she never undergoes screening?
1/200 chance that is a fatal decision
What are the chances a women who is diagnosed with breast cancer will undergo unnecessary surgery?
1/65 chance of unnecessary surgery
What factors affect the effectiveness of screening and successful treatment?
Efficacy of the screening method
Potential of effective treatment
Efficacy and accuracy of the screening method must outweigh the associated costs of the screening and the associated risks of the treatment = Balance
What is the purpose of a Pap smear?
Pap smears attempt to detect cervical cancer (introduced in the 1930s)
Why have survival rates of cervical cancer improved significantly over the last 40 years?
Screening improvements
What is the current screening technique used to diagnose bowel cancer?
FOBT Foecal Occult Blood Test
Blood in the foeces can be triggered by the formation of polyps on the colon lining.
What techniques are avaiable to diagnose bowel cancer?
FOBT Foecal Occult Blood Test
Colonoscopy
Is FOBT or Colonoscopy more specific for the detection of polyps and colon cancer?
Colonoscopy detects 4-5x more polyps and cancers than FOBT
What is the difference in cost between FOBT and Colonoscopy?
Colonoscopy is 10x more expensive than FOBT but Colonoscopy is 10x better at polyp detection.
What is a future technique for the detection of polpys and colon cancer?
Virtual colonoscopy
Computerised tomography (CAT scan). A series of X-rays. Almost as sensitive as colonoscopy but 1/3 cost and lower risk.
What are the advantages of chemotherapy?
Very toxic to target cells
Knowledge of the tumour is not required
Radiation can be targeted