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Cancer syndrome to consider based on indication Flashcards

1
Q

>5 cumulative basal cell carcinomas (BCCs) or BCC dx at age 30 or under

A

Nevoid basal cell carcinoma syndrome (NBCCS) (Gorlin Syndrome)

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2
Q

Brain tumor dx before 18

A

Mismatch repair cancer syndrome (CMMRD)

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3
Q

Brain tumor and two additional cases of any LS-associated cancer in the same person or in relatives

A

Lynch Syndrome (LS)

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4
Q

Brain tumor and one additional tumor in the same person or in two relatives, one dx 45 or under

A

Li Fraumeni syndrome (tumor should be a LFS-associated tumor)

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5
Q

Astrocytoma and melanoma in the same person or in two first-degree relatives

A

Melanoma-Astrocytoma Syndrome (MAS)

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6
Q

Subependymal giant cell astrocytoma and one additional criteria in the same person

A

Tuberous Sclerosis Complex

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7
Q

Medulloblastoma and >10 cumulative adenomatous colon polyps in the same person

A

FAP

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8
Q

Medulloblastoma (PNET) dx at age 18 or under

A

Nevoid basal cell carcinoma syndrome (NBCCS) (Gorlin Syndrome)

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9
Q

Breast cancer dx at 35 or younger

A

HBOC or Li-Fraumeni

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10
Q

Triple-negative breast cancer dx at 60 or younger

A

HBOC

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11
Q

2+ primary breast cancers in the same person

A

HBOC

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12
Q

AJ ancestry and breast cancer at any age

A

HBOC

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13
Q

3 or more cases of breast, ovarian, pancreatic, and/or aggressive prostate cancer in close relatives, inclinding the patient

A

HBOC

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14
Q

Breast cancer and one additional LFS tumor in the same person or in two relatives, one dx at age 45 or younger

A

Li-Fraumeni Syndrome

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15
Q

Breast cancer and 1+ PJ polyp in the same person

A

Peutz-Jeghers Syndrome (PJS)

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16
Q

Lobular breast cancer and diffuse gastric cancer in the same person

A

Hereditary diffuse gastric cancer (HDGC)

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17
Q

Lobular breast cancer in one relative and diffuse gastric cancer in another, one dx at age 50 or under

A

Hereditary diffuse gastric cancer (HDGC)

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18
Q

Breast cancer and 2 additional criteria (ex. macrocephaly, LDD tumor)

A

Cowden syndrome

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19
Q

Male breast cancer

A

HBOC

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20
Q

Colorectal cancer dx before 50 years of age

A

Lynch-Syndrome (LS), Mismatch repair cancer syndrome (CMMRD), MUTYH-associated polyposis (MAP)

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21
Q

Colorectal cancer dx 50+ with an first-degree relative with colorectal or endometrial cancer at any age

A

Lynch-Syndrome (LS), Mismatch repair cancer syndrome (CMMRD), MUTYH-associated polyposis (MAP)

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22
Q

Synchronous or metachronous colorectal or endometrial cancers in the same person

A

Lynch-Syndrome (LS), Mismatch repair cancer syndrome (CMMRD), MUTYH-associated polyposis (MAP)

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23
Q

Colorectal cancer showing mismatch repair deficiency on tumor screening

A

Lynch-Syndrome (LS) or Mismatch repair cancer syndrome (CMMRD)

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24
Q

Colorectal cancer and two additional cases of any LS-associated cancer in the same person or in close relatives

A

Lynch-Syndrome (LS), Mismatch repair cancer syndrome (CMMRD)

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25
Q

Colorectal cancer and two additional criteria (ex. macrocephaly, LDD tumor)

A

Cowden Syndrome (criteria = cowden syndrome criteria)

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26
Q

Colorectal cancer and one additional tumor in the same person or in two relatives, one dx at 45 or younger

A

Lynch Syndrome

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27
Q

Colorectal cancer with 10+ cumulative adenomatous colon polyps in the same person

A

FAP, AFAP, MUTYH-associated polyposis (MAP)

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28
Q

10+ cumulative adenomatous colon polyps in the same person

A

FAP, MAP, AFAP

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29
Q

3-5 cumulative histologically proven juvenile polyps in the same person

A

Juvenile-polyposis syndrome (JPS)

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30
Q

Any number of juvenile polyps with a positive family hx

A

Juvenile-polyposis syndrome (JPS)

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31
Q

Multiple juvenile polyps throughout the GI tract in the same person

A

Juvenile-polyposis syndrome (JPS)

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32
Q

One PJ polyp and mucocutaneous hyperpigmentation in the same person

A

Peutz-Jeghers Syndrome (PJS)

33
Q

GI hamartoma or ganglioneuroma and two additional critera

A

Cowden Syndrome

34
Q

Rectal hamartomatous polyps and one additional criterion

A

Tuberous Sclerosis Complex

35
Q

Diffuse ganglioneuromatosis of the GI tract

36
Q

5+ serrated polyps proximal to the sigmoid colon, two of which are >1 cm in diameter, in the same person

A

Serrated Polyposis Syndrome (SPS)

37
Q

20+ serrated polyps at any site in the large bowel in the same person

A

Serrated Polyposis Syndrome (SPS)

38
Q

Any number of SPs proximal to the sigmoid colon and a positive family history

A

Serrated Polyposis Syndrome (SPS)

39
Q

10+ cumulative polyps with >1 histology in the same person

A

Hereditary Mixed Polyposis Syndrome (HMPS)

40
Q

Endometrial cancer diagnosed at younger than 50 years of age

A

Lynch Syndrome

41
Q

Endometrial cancer dx at age 50+ with a first degree relative with colorectal or endometrial cancer at any age

A

Lynch Syndrome

42
Q

Synchronous or metachronous colorectal or endometrial cancer

A

Lynch Syndrome

43
Q

Endometrial cancer showing mismatch repair deficiency on tumor screening

A

Lynch Syndrome

44
Q

Epithelial endometrial cancer and macrocephaly

A

Cowden Syndrome

45
Q

2 or more cases of gastric cancer, one dx younger than 50 years of age

A

Hereditary diffuse gastric cancer (HDGC)

46
Q

3 or more cases of gastric cancer in close relatives

A

Hereditary diffuse gastric cancer (HDGC)

47
Q

Diffuse gastric cancer at younger than 40 years of age

A

Hereditary diffuse gastric cancer (HDGC)

48
Q

Diffuse gastric cancer and lobular breast cancer in the same person

A

Hereditary diffuse gastric cancer (HDGC)

49
Q

Diffuse gastric cancer in one relative and lobular breast cancer in another, one dx before 50 years of age

A

Hereditary diffuse gastric cancer (HDGC)

50
Q

Gastric cancer and 2 additional cases of any LS-associated cancer in the same person or in close relatives

A

Lynch Syndrome

51
Q

Leukemia dx before 18 years of age plus cafe-au-lait macules and/or other signs of NF1, or hypopigmented skin lesions, or consaguineous parents, or family history of LS-associated cancers, second primary cancer, sibling with a childhood cancer

A

Mismatch repair cancer syndrome (CMMRD)

52
Q

Leukemia and one additional tumor in the same person or in 2 close relatives, one dx at 45 years or younger

A

Li-Fraumeni Syndrome (tumor should be a LFS criteria one)

53
Q

3+ cases of melanoma and/or pancreatic cancer in close relatives

A

Hereditary Melanoma (HM)

54
Q

3 or more primary melanomas in the same person

A

Hereditary Melanoma (HM)

55
Q

Melanoma and pancreatic cancer in the same person

A

Hereditary Melanoma (HM)

56
Q

Melanoma and astrocytoma in the same person or in 2 first-degree relatives

A

Hereditary Melanoma (HM) or Melanoma-Astrocytoma Syndrome (MAS)

57
Q

Ovarian/Fallopian tube/Primary peritoneal cancer

A

HBOC, Lynch Syndrome

58
Q

Pancreatic cancer dx at any age, if any of the following criteria are met: - 2+ cases of pancreas cancer in close relatives - 2+ cases of breast, ovarian, and/or aggressive prostate cancer in close relatives - AJ ancestry

A

HBOC, Familial Pancreatic Cancer

59
Q

Pancreatic cancer and 1 or more PJ polyp in the same person

A

Peutz-Jeghers Syndrome (PJS)

60
Q

Pancreatic cancer and two additional cases of any Lynch-associated cancer in the same person or in close relatives

A

Lynch Syndrome

61
Q

3+ cases of pancreatic cancer and/or melanoma in close relatives

A

Hereditary Melanoma (OMIM 155600)

62
Q

2+ cases of prostate cancer at age 55 or younger in close relatives

A

Familial Prostate Cancer (FP)

63
Q

3 or more first degree relatives with prostate cancer

A

Familial Prostate Cancer (FP)

64
Q

Aggressive (Gleason score >7) prostate cancer and 2+ cases of breast, ovarian, and/or pancreas cancer in close relatives

65
Q

Renal cell carcinoma (RCC) with clear cell histology, if any of the following criteria are met: diagnosed before age 50, bilateral or multifocal tumors, 1 close relative with clear cell RCC

A

von-Hippel Lindau (VHL), Birt-Hogg-Dube (BHD)

66
Q

RCC with papillary type 1 histology

A

Hereditary papillary renal cancer (HPRC)

67
Q

RCC with papillary type 2 histology

A

Hereditary leiomyomatosis and renal cell carcinoma (HLRCC)

68
Q

RCC with collecting duct histology

A

Hereditary leiomyomatosis and renal cell carcinoma (HLRCC)

69
Q

RCC with tubulopapillary histology

A

Hereditary leiomyomatosis and renal cell carcinoma (HLRCC)

70
Q

RCC with crhomophobe, oncocytoma, or oncocytic hybrid

A

Birt-Hogg-Dube (BHD)

71
Q

Urothelial carcinoma (or transitional cell carcinoma) and 2 additional cases of cancer in the same person or in relatives

A

Lynch Syndrome

72
Q

RCC and macrocephaly

A

Cowden Syndrome

73
Q

Angiomyolipomas of the kidney and one addtional criteria

A

Tuberous Sclerosis complex

74
Q

Medullary Thyroid Cancer

75
Q

Nonmedullary thyroid cancer and one additional criteria

76
Q

Nonmedullary thyroid cancer and 2 additional criteria

77
Q

Papillary thyroid cancer (cribriform-morular variant)

78
Q

Colorectal adenocarcinoma

A

Lynch Syndrome associated tumor

Comps (24 decks)

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