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Comps > Cancer Syndrome Criteria > Flashcards

Cancer Syndrome Criteria Flashcards

1
Q
  • Spotty skin pigmentation on lips, conjunctiva and inner or outer canthi, and/or vaginal or penila mucosa
A

Carney Complex criteria

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2
Q
  • Large cell calcifying Sertoli cell tumor or characterstic calcification on testicular U/S
A

Carney Complex criteria

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3
Q
  • Myxoma (cutaneous and mucosal)
A

Carney Complex criteria

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4
Q
  • Cardiac myxoma
A

Carney Complex criteria

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5
Q
  • Breast myxomatosis or fat-suppressed MRI findings suggestive of this dx
A

Carney Complex criteria

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6
Q
  • Acromegaly due to growth hormone-producing adenoma
A

Carney Complex criteria

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7
Q
  • Primary pigmented nodular adrenocortical dysplasia
A

Carney Complex criteria

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8
Q

Thyroid carcinoma (nonmedullary) or multiple hypoechoic nodules on thyroid U/S in a young patient

A

Carney Complex criteria

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9
Q

Psammomatous melanotic schwannoma

A

Carney Complex criteria

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10
Q

Blue nevus, epithelioid blue nevus (multiple)

A

Carney Complex criteria

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11
Q

Breast ductal adenoma (multiple)

A

Carney Complex criteria

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12
Q

Osteochondromyxoma

A

Carney Complex criteria

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13
Q

Breast cancer is a major criteria piece for _________

A

Cowden Syndrome Major Criteria

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14
Q

Endometrial cancer (epithelial)

A

Cowden Syndrome Major Criteria

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15
Q

Follicular Thyroid Cancer

A

Cowden Syndrome Major Criteria

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16
Q

GI hamartomas (including ganglioneuromas but excluding hyperplastic polyps; 3 or more)

A

Cowden Syndrome Major Criteria

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17
Q

Lhermitte-Duclos disease (adult)

A

Cowden Syndrome Major Criteria

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18
Q

Macrocephaly (58 cm for women, 60 cm for men; 97th+ percentile)

A

Cowden Syndrome Major Criteria

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19
Q

Macular pigmentation of the glans penis

A

Cowden Syndrome Major Criteria

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20
Q

Multiple mucocutaneous lesions (any of the following): - multiple trichilemmomas (3+, at least 1 proven by biopsy) - Acral keratoses (3+ palmoplantar keratotic pits and/or acral hyperkeratotic papules) - Mucocutaneous neuromas (3+) - Oral papillomas (particularly on tongue and gingival), multiple (3+) OR biopsy proven OR dermatologist diagnosed

A

Cowden Syndrome Major Criteria

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21
Q

Autism spectrum disorder

A

Cowden Syndrome Minor Criteria

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22
Q

Colon cancer

A

Cowden Syndrome Minor Criteria

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23
Q

Esophageal glycogenic acanthosis (3+)

A

Cowden Syndrome Minor Criteria

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24
Q

Lipomas (3+)

A

Cowden Syndrome Minor Criteria

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25
Q

Intellectual disability (ie. IQ

A

Cowden Syndrome Minor Criteria

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26
Q

Renal cell carcinoma

A

Cowden Syndrome Minor Criteria

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27
Q

Testicular lipomatosis

A

Cowden Syndrome Minor Criteria

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28
Q

Thyroid cancer (papillary or follicular variant of papillary)

A

Cowden Syndrome Minor Criteria

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29
Q

Thyroid structural lesions (e.g. adenoma, multinodular goiter)

A

Cowden Syndrome Minor Criteria

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30
Q

Vascular anomalies (including multiple intracranial developmental

A

Cowden Syndrome Minor Criteria

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31
Q

Soft-tissue sarcoma

A

Li-Fraumeni Syndrome associated tumor

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32
Q

Osteosarcoma

A

Li-Fraumeni Syndrome associated tumor

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33
Q

Brain tumor

A

Li-Fraumeni Syndrome associated tumor

34
Q

Breast cancer (often before 35)

A

Li-Fraumeni Syndrome associated tumor

35
Q

Adrenocortical tumor

A

Li-Fraumeni Syndrome associated tumor

36
Q

Leukemia

A

Li-Fraumeni Syndrome associated tumor

37
Q

Bronchoalveolar cancer (type of lung cancer)

A

Li-Fraumeni Syndrome associated tumor

38
Q

Colorectal cancer

A

Li-Fraumeni Syndrome associated tumor

39
Q

Colorectal adenocarcinoma

A

Lynch Syndrome associated tumor

40
Q

Endometrial adenocarcinoma

A

Lynch Syndrome associated tumor

41
Q

Urothelial carcinoma (ureter and renal collecting ducts)

A

Lynch Syndrome associated tumor

42
Q

Gastric cancer

A

Lynch Syndrome associated tumor

43
Q

Ovarian

A

Lynch Syndrome associated tumor

44
Q

Small bowel cancer

A

Lynch Syndrome associated tumor

45
Q

Glioblastoma

A

Lynch Syndrome associated tumor

46
Q

Sebaceous Adenocarcnioma

A

Lynch Syndrome associated tumor

47
Q

Biliary tract cancer

A

Lynch Syndrome associated tumor

48
Q

Pancreatic cancer

A

Lynch Syndrome associated tumor

49
Q

Lamellar calcification of the falx in an individual younger than age 20

A

Nevoid basal cell carcinoma syndrome (Gorlin Syndrome) major criteria

50
Q

Jaw keratocyst

A

Nevoid basal cell carcinoma syndrome (Gorlin Syndrome) major criteria

51
Q

Palmar or Plantar pits

A

Nevoid basal cell carcinoma syndrome (Gorlin Syndrome) major criteria

52
Q

Multiple basal cell carinomas (>5 in a lifetime) or a basal cell carcinoma dx before age 30 (excluding BCC that develop after radiotherapy)

A

Nevoid basal cell carcinoma syndrome (Gorlin Syndrome) major criteria

53
Q

Childhood medulloblastoma (primitive neuroectodermal tumor)

A

Nevoid basal cell carcinoma syndrome (Gorlin Syndrome) minor criteria

54
Q

Lymphomesenteric or pleural cysts

A

Nevoid basal cell carcinoma syndrome (Gorlin Syndrome) minor criteria

55
Q

Macrocephaly (occipital frontal circumference >97th percentile)

A

Nevoid basal cell carcinoma syndrome (Gorlin Syndrome) minor criteria

56
Q

Cleft lip or cleft palate

A

Nevoid basal cell carcinoma syndrome (Gorlin Syndrome) minor criteria

57
Q

Vertebral or rib anomalies observed on X-ray

A

Nevoid basal cell carcinoma syndrome (Gorlin Syndrome) minor criteria

58
Q

Preaxial or post axial polydactyly

A

Nevoid basal cell carcinoma syndrome (Gorlin Syndrome) minor criteria

59
Q

Ovarian or cardiac fibromas

A

Nevoid basal cell carcinoma syndrome (Gorlin Syndrome) minor criteria

60
Q

Ocular anomalies (cataract, developmental defects, and pigmentary changes of the retinal epithelium)

A

Nevoid basal cell carcinoma syndrome (Gorlin Syndrome) minor criteria

61
Q

Facial angiofibromas or forehead plaque

A

Tuberous sclerosis complex major criteria

62
Q

Nontraumatic ungual or periungual fibroma

A

Tuberous sclerosis complex major criteria

63
Q

Hypomelanotic macules (3+)

A

Tuberous sclerosis complex major criteria

64
Q

Shagreen patch (connective tissue nevus)

A

Tuberous sclerosis complex major criteria

65
Q

Cortical tuber in the brain

A

Tuberous sclerosis complex major criteria

66
Q

Subependymal glial nodule

A

Tuberous sclerosis complex major criteria

67
Q

Subependymal giant cell astrocytoma

A

Tuberous sclerosis complex major criteria

68
Q

Multiple retinal nodular hamartomas

A

Tuberous sclerosis complex major criteria

69
Q

Cardiac rhabdomyomas, single or multiple

A

Tuberous sclerosis complex major criteria

70
Q

Lymphangiomyomatosis

A

Tuberous sclerosis complex major criteria

71
Q

Renal angiomyolipoma

A

Tuberous sclerosis complex major criteria

72
Q

Multiple, randomly distributed pits in dental enamel

A

Tuberous sclerosis complex minor criteria

73
Q

Hamartomatous rectal polyps

A

Tuberous sclerosis complex minor criteria

74
Q

Bone cysts

A

Tuberous sclerosis complex minor criteria

75
Q

“Confetti” skin lesions

A

Tuberous sclerosis complex minor criteria

76
Q

Multiple renal cysts

A

Tuberous sclerosis complex minor criteria

77
Q

Nonrenal hamartoma

A

Tuberous sclerosis complex minor criteria

78
Q

Cerebral white matter radial migration lines

A

Tuberous sclerosis complex minor criteria

79
Q

Retinal achromic patch

A

Tuberous sclerosis complex minor criteria

80
Q

Gingival fibromas

A

Tuberous sclerosis complex minor criteria

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