Cancer Risk Models

Question 1

GAIL/BCRAT includes

Answer 1

only first degree female relatives
Age at menarche and first live birth
Breast biopsies

Question 2

GAIL/BCRAT risks calculated

Answer 2

Lifetime and 5 year

Question 3

CLAUS includes

Answer 3

affected first and second degree relatives, with age of onset

Question 4

Claus risk calculated

Answer 4

lifetime

Question 5

Tyrer-Cuzick includes

Answer 5

affected and unaffected 1st, 2nd, and 3rd degree female relatives with age of onset
Age at menarche, first live birth, menopause, HRT, BMI
Breast biopsies

Question 6

Tyrer-Cuzick risks calculated

Answer 6

lifetime and 10 year

Question 7

BRCAPRO includes

Answer 7

affected and unaffected 1st, 2nd, and 3rd degree relatives (male and female) with age of onset

Question 8

BRCAPRO risk calcualted

Answer 8

lifetime

Question 9

BOADICEA includes

Answer 9

affected and unaffected 1st and 2nd degree female relatives with age of onset

Question 10

BOADICEA risk calculated

Answer 10

Lifetime

Question 11

Gail limitations

Answer 11

can’t be used for females under 35
only includes 1st degree relatives and no ages of diagnosis

Question 12

Tyrer-Cuzick limitations

Answer 12

may overestimate risk of breast cancer

Question 13

BRCAPRO limitations

Answer 13

underestimates carrier frequency of ovarian and prostate risks

Question 14

Conditional Probability

Answer 14

(R(y)-R(x))/(1-R(x))

Question 15

Myriad II Prevalence Tables use

Answer 15

predict prior probability of BRCA1/2 mutation

Question 16

PENN II use

Answer 16

a priori risk of BRCA1/2 pathogenic variant

Question 17

Which in situ form is considered cancer

Answer 17

DCIS
LCIS (not considered cancer)