Cancer Proteins and their tumor Flashcards
MiR-200
Genera metastasis
MiR-155
B cell lymphoma(block MYC)
MiR-15,16
Chronic Lymphoid leukemia
BCL-2
HPV
Strains…
Viral protein
Host protein
Cancer
16,18
E6,E7
p53, RB
Cervical, oropharyngeal
BCL-2
Follicular lymphoma(B cell)
ERB1
Cancer
Protein
Lung adenocarcinoma
EGFR
ERB2
Cancer
Protein
Breast cancer
HER2
EML4-ALK
Lung adenocarcinoma
RAS
CARCINOMA
Pancreas, gall bladder, colon, lung, endometrial, thyroid, myeloid leukemia
BRAF
Hairy cell leukemia, melanoma, benign nevi(Moles)
SHH
Holoprosenceohaly, basal cell carcinoma
Brain, lung, prostate, mammary
MYC
Burkett Lymphoma, neuroblastoma, CARCINOMAS
APC
Colon cancer,
VHL
carcinoma
Retina, cerebellum, kidney
RB
Retinoblastoma, osteosarcoma, glioblastoma, small cell carcinoma lung, breast, bladder, oropharyngeal(E7)
P53
Lung, colon, breast carcinomas
Wt-1
Pediatric kidney cancer
MLL-1
Acute leukemia
MLL-2
Follicular lymphoma
SNF5
Malignant rhabdoid tumor
Radiation
Targets (4)
Resistant(3)
Myeloid leukemia, breast, lung, salivary
Skin, bone, GI