Cancer Markers

Question 1

α-Fetoprotein (AFP)

Answer 1

Hepatocellular carcinoma and yolk sac tumors

Question 2

Actin

Answer 2

Muscle tumors

Question 3

BCL-2

anti-apoptotic gene BCL2 is overexpressed due to a (14;18) translocation.

Answer 3

Follicular lymphomas

Question 4

Ca-125

Answer 4

Ovarian carcinoma

Question 5

Calcitonin

Answer 5

Thyroid medullary carcinoma

Question 6

Carcinoembryonic antigen (CEA) and CA-19-9

Answer 6

Colon and pancreatic carcinoma

Question 7

Catecholamines and derivatives

Answer 7

Pheochromocytoma

Question 8

CD markers, e.g., CD20

Answer 8

Lymphomas and leukemias

Question 9

CD31

Answer 9

Blood vessel tumors = endothelial tumors

Question 10

Estrogen receptors and HER2 (ERBB2)

Answer 10

Breast carcinoma

Question 11

Glial fibrillary acidic protein (GFAP)

Answer 11

Gliomas

Question 12

HMB-45

Answer 12

Melanoma

Question 13

Human chorionic gonadotropin (hCG)

Answer 13

Choriocarcinoma

Question 14

Intermediate filaments: cytokeratin, desmin, vimentin

Answer 14

Epithelial, mesenchymal, and neural tumors

Question 15

Neuron-specific enolase

Answer 15

Small cell lung carcinoma, neuroblastoma

Question 16

Prostate-specific antigen (PSA)

Answer 16

Prostate carcinoma

Question 17

S100

Answer 17

Melanoma and neural tumors

Question 18

Cag A

Answer 18

Gastric cancer caused by H Pylori