Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

STEP Pharm II > Cancer Drugs MOAs and AEs > Flashcards

Cancer Drugs MOAs and AEs Flashcards

1
Q

Carboplatin/Cisplatin

A

Forms DNA intrastrand crosslinks and adducts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Cyclophosphamide/Ifosfamide

A

Pro-drug of active alkylating moiety

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Docetaxel/Paclitaxel

A

Microtubule stabilizer inhibiting depolymerization

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Doxorubicin

A

Intercalator, free radical generator, too II inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Etoposide, VP-16

A

DNA-topo II complex stabilizer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Gemcitabine

A

DNA polymerase inhibitor via incorporation of triphosphate form during DNA synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Irinotecan/Topotecan

A

DNA-topo I complex stabilizer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Pemetrexad

A

DHFR Inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Vincristine/Vinorelbine

A

Microtubule inhibitor; tubules disintegrate into spiral aggregates/ protofilaments

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Which is more toxic, Cisplatin or Carboplatin?

A

Cisplatin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Toxicities of Carboplatin/Cisplatin?

A

-**Nephro and ototoxicity (dose-limiting toxicity)-peripheral neuropathy (more in cisplatin- numbness in distal extremities)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What drug is often given with Carboplatin/Cisplatin to prevent nephrotoxicity?

A

Amifostine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

AEs of Cyclophosphamide /Ifosfamide

A

Hemorrhagic cystitis from acrolein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

AEs of Docetaxel/Paclitaxel

A

-hypersensitivity-diarrhea-mucositis-peripheral neuropathy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

AEs of Doxorubicin?

A

-red-orange urine -chronic cardiomyopathy and CHF from free radicals-cardiac arryhthmias

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

How are the CV AEs of Doxorubicin avoided?

A

Dexrazoxane

17
Q

AEs of Etoposide, VP-16

A

-hypotension-hypersensitivity-N/V

18
Q

AEs of Gemcitabine?

A

-interstitial pneumonitis-mucositis-diarrhea

19
Q

AEs of Irinotecan/Topotecan?

A

-asthenia-N/V

20
Q

AEs of Pemetrexed?

A

-hepatic fibrosis-pneumonitis-mucositis-diarrhea

21
Q

What drug is given to prevent the toxicities of Pemetrexed?

A

Leucovorin

22
Q

AEs of Vinblastine/Vinorelbine?

A

-SIADH with vincristine-constipation-peripheral neuropathy

23
Q

Two other drugs associated with peripheral neuropathy?

A

bortezomib and thalidomide

STEP Pharm II (42 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions