Cancer Chemotherapy Drugs Flashcards
(95 cards)
1
Q
Casodex/eulixin/nilandron MOA (2):
A
- Blocks androgen-induced growth.
- Normally combined with leuprolide or other LH releasing hormone agonist.
2
Q
Mercaptopurine toxicities (2):
A
- Cholestasis
- Oral and intestinal ulcers
3
Q
Bendamustine cell cycle profile:
A
CCNS
4
Q
Cyclophosphamide cell cycle profile:
A
CCNS
5
Q
Pentostatin/cladribine/fludarabine use:
A
Hairy cell leukemia.
6
Q
Busulfan cell cycle profile:
A
CCNS
7
Q
Docetaxel MOA:
A
Prevents MT depolymerization by binding to and stabilizing polymerized tubulin.
8
Q
Leucovorin rescue:
A
Drug is used to minimize the toxic effects of folate depletion in normal cells. Bypasses the metabolic block induced by MTX.
9
Q
Vincristine/vinblastine/vinorelbine toxicities (3):
A
- Peripheral neuropathy
- Alopecia
- Nephrogenic SIADH secretion
10
Q
Interferons cell cycle profile:
A
CCNS
11
Q
Prednisone MOA (2):
A
- Anti-inflammatory properties and alter immune responses.
- Cause apoptosis in leukemic cells.
12
Q
Procarbazine MOA:
A
Blocks DNA replication and transcription. Damages DNA.
13
Q
Doxorubicin/daunorubicin cell cycle profile:
A
CCNS
14
Q
CVD use:
A
Pheochromocytoma
15
Q
Vincristine/vinblastine/vinorelbine MOA:
A
Bind specifically to soluble tubulin of MTs, block polymerization and arrest cellular mitosis in metaphase.
16
Q
Cytarabine cell cycle profile:
A
S phase
17
Q
Dacarbazine/temozolomide:
A
Methylates DNA and RNA.
18
Q
Dactinomycin Toxicity (2):
A
- Oral and GI ulceration.
- Stomatitis
19
Q
Fluorouracil 5-FU toxicities (2):
A
- Oral and GI ulceration.
- Stop at early signs of stomatitis and diarrhea.
20
Q
Carmustine/Lomustine/Semustine/Streptozocin toxicity (3):
A
- Pulmonary fibrosis
- Nephrotoxicity
- Streptozotocin: pancreatic
21
Q
Dacarbazine/temozolomide MOA:
A
Blocks DNA replication and transcription. Damages DNA.
22
Q
CHOP use:
A
Non-hodgkin’s disease
23
Q
Bleomycins toxicity (3):
A
- Pulmonary fibrosis.
- Pneumonitis.
- Cutaneous reaction.
24
Q
Docetaxel toxicity:
A
Peripheral neuropathy
25
BEP use:
Ovarian
26
Cytarabine toxicity:
Oral ulceration
27
BIP use:
Cervical
28
Procarbazine (4):
- Decrease DNA, RNA, protein synthesis.
- Chromatid breakage and translocation.
- Inhibits G1 --> S.
- Avoid MAO inhibitors and alcohol.
29
Camptothecin/topotecan/irinotecan cell cycle profile:
S-phase
30
CAF use:
Breast
31
Chlorambucil toxicity:
Hepatotoxicity
32
Mercaptopurine cell cycle profile:
S phase
33
Etoposide/Tenopside MOA:
Forms a ternary complex with DNA and topisomerase II.
34
Procarbazine cell cycle profile:
CCNS
35
Pentostatin/cladribine/fludarabine MOA:
Inhibit adenosine deaminase directly or via metabolites --> build up of adenosine and deoxyadenosine decreases DNA synthesis by inhibiting ribonucleotide reductase.
36
Doxorubicin/daunorubicin MOA (2):
- Blocks activity of topoisomerase II.
| - Binds between base pairs of DNA --> ROS.
37
Denusomab MOA:
Blocks RANK-RANKL in bone.
38
Interferons MOA (2):
- Inhibits tumors by regulating the host immune system.
| - Direct activity against cancer cells.
39
Dactinomycin:
Peptide loops of dG-dC.
40
Cisplatin/Carboplatin/oxaloplatin cell cycle profile:
CCNS
41
Crizotinib MOA:
Blocks ALK-1 kinase
42
Prednisone uses (2):
- Hodgkin's disease.
| - Manage hemolytic anemia and hemorrhagic complications.
43
Bleomycins MOA:
Creates ROS.
44
Paclitaxel MOA:
Prevents MT depolymerization by binding to and stabilizing polymerized tubulin.
45
Mercaptopurine 6-MP MOA:
Inhibits synthesis of adenine and guanine by blocking conversion of inosinate to purine precursors.
46
Imatinib MOA:
Blocks Bcr-Abl kinase
47
Estramustine phosphate cell cycle profile:
CCNS and M-phase.
48
Cisplatin/Carboplatin/oxaloplatin toxicity (3):
- Nephrotoxicity
- Peripheral neuropathy
- Ototoxicity
49
Progestins MOA:
Used in hormone responsive cancers expressing progesterone receptors.
50
PACE use:
Small cell lung cancer
51
CMF use:
Breast
52
Bleomycins cell cycle profile:
G2 phase.
53
Chlorambucil MOA:
Blocks DNA replication and transcription. Damages DNA.
54
PEB use:
Testicular
55
Cisplatin/Carboplatin/oxaloplatin MOA:
Binds guanine in DNA and forms intra-strand crosslinks/adducts.
56
Busulfan toxicity (2):
- Pulmonary fibrosis.
| - Hyperpigmentation.
57
VIP use:
Germ cell
58
Cyclophosphamide:
Must be activated by CYP 450 in the liver.
59
Doxorubicin/daunorubicin toxicity (2):
Cardiotoxicity
| - Can be prevented with dexrazoxane, expensive.
60
Carmustine/Lomustine/Semustine/Streptozocin MOA:
Blocks DNA replication and transcription. Damages DNA.
61
Tamoxifen/foremefine use:
Used in estrogen receptor positive breast cancer.
62
Busulfan MOA:
Blocks DNA replication and transcription. Damages DNA.
63
MOPP use:
Hodgkin's disease.
64
Vincristine/vinblastine/vinorelbine cell cycle profile:
M phase
65
Dactinomycin MOA:
Interaction of peptide loops at purine-pyrimidine base pairs of DNA and intercalate between the DNA strands, prevents transcription.
66
Etoposide/Tenopside cell cycle profile:
CCNS but kills in S and G2 phases.
67
ABVD use:
Hodgkin's disease.
68
Mitoxantrone MOA:
Binds to DNA and blocks topisomerase II leading to DNA strand breaks.
69
Cyclophosphamide MOA:
Blocks DNA replication and transcription. Damages DNA.
70
Fluorouracil 5-FU cell cycle profile:
CCNS
71
Bendamustine MOA:
Blocks DNA replication and transcription. Damages DNA.
72
Methotrexate/Trimetrexate/pemetrexed cell cycle profile:
S phase
73
Trastuzumab MOA:
Blocks Her2/c-Neu
74
Estramustine phosphate MOA:
Blocks DNA replication and transcription. Damages DNA.
75
Docetaxel cell cycle profile:
M phase
76
MESNA (2):
- Reacts with acrolein in urine to detoxify and prevent binding to bladder wall.
- Decrease hemorrhagic cystitis produced by acrolein.
77
M-BACOD
Lymphomas
78
Methotrexate/Trimetrexate/pemetrexed toxicities (3):
- Oral and GI ulceration
- Hepatotoxicity
- Pulmonary toxicity
79
Camptothecin/topotecan/irinotecan MOA:
Inhibitors of topoisomerase I.
80
Erlotinib/gefitinib MOA:
Blocks EGFR signaling.
81
Carmustine/Lomustine/Semustine/Streptozocin cell cycle profile:
CCNS
82
Chlorambucil cell cycle profile:
CCNS
83
Mechlorethamine MOA:
Blocks DNA replication and transcription. Damages DNA.
84
Fluorouracil 5-FU MOA:
Decrease DNA synthesis by blocking thymidylate synthesis --> not enough nucleotides and will use FUTP and FdUTP --> cell damage and death.
85
Thioguianine 6-TG MOA:
Inhibits several steps in biosynthesis of purines.
86
Bevuczimab MOA:
Blocks VEGF-R and prevents angiogenesis.
87
Dacarbazine/temozolomide cell cycle profile:
CCNS
88
Methotrexate/Trimetrexate/pemetrexed MOA (2):
- MTX inhibits DHF reductase to block biosynthesis of thymidylate and purines --> decrease in DNA synthesis.
- Pemetrexed directly inhibits thymidylate synthase.
89
Estramustine phosphate (4):
- Given orally.
- Phosphate cleaved during absorption.
- In vivo binds to beta-tubulin.
- Anti-mitotic effects.
90
Cyclophosphamide toxicity (2):
- Hemorrhagic cystitis.
| - SIADH.
91
Paclitaxel toxicity:
Peripheral neuropathy.
92
Paclitaxel cell cycle profile:
M phase
93
Mechlorethamine cell cycle profile:
CCNS
94
Thioguianine cell cycle profile:
S phase
95
Cytarabine MOA:
Inhibits DNA polymerase alpha incorporation into DNA --> unstable.
