Cancer Chemotherapy - Anti-metabolites

Question 1

What are Antimetabolites?

Answer 1

Toxic analogues of essential precursors for macromolecules

Question 2

Antimetabolites are designed for what 2 purposes?

Answer 2

• To inhibit essential enzymes
• Distrupt the formation of macromolecules (includes DNA and RNA)

Question 3

Folic acid if important in the formation of _________ _________

Answer 3

Pyrimidine bases

Question 4

Pyrimidine bases are involved in the synthesis of _____ , ______ and ________.

Answer 4

DNA / RNA / Proteins

Question 5

5-FdUMP (5-fluoro-deoxyuridine monophosphate) is MORE POTENT than 5-FU (5-fuorouracil). True or False

Answer 5

True - Therefor 5-FU needs to be metabolised to 5-FdUMP.

Question 6

5-FU is incorporated into ______ and ______.

Answer 6

RNA and DNA

Question 7

Why is 5-FU less incorporated into DNA?

Answer 7

5-FU is a uracil analogue

Question 8

Capecitabine is a prodrug of _________

Answer 8

5-FU

Question 9

Antifolates inhibit the synthesis or DNA, RNA and what else?

Answer 9

Thymidylates and proteins

Question 10

What do Anti-metabolites inhibit?

Answer 10

They inhibit metabolic processes that generate nucleic acids required in proliferating cells

Question 11

5-FU generates a ‘frozen’ transition state complex when inhibiting….

Answer 11

Thymidylate synthase

Question 12

What are newer versions of anti-metabolites called?

Answer 12

Prodrugs