Cancer Cell Biology Flashcards

1
Q

A cancer without invasion of tissue

A

Benign

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2
Q

It has tissue invasion

A

Malignant

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3
Q

Cancers that are derived from EPITHELIAL TISSUE are called?

A

Carcinoma

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4
Q

Cancer that is derived from MESYNCHYMAL tissue is called?

A

Sarcoma

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5
Q

Those derived from hematopoietic cell is called?

A

Leukemia, lymphoma and plasma cell dyscrasias

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6
Q

It is a cell Cycle check point that function for growth and preparation for DNA synthesis?

A

G1

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7
Q

DNA synthesis cell cycle check point

A

S phase

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8
Q

What pathway is activated when DNA damage is detected

A

P53 pathway

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9
Q

What is the most frequent mutations in human CA?

A

P53 MUTATION ON CHROMOSOME 17p

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10
Q

What are the 2 oncogenes of virus

A

E6 and e7

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11
Q

It acts to INCREASE the rapid turn over of p53

A

E6

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12
Q

It INHIBITS the Rb function

A

E7

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13
Q

An abnormality in spindle checkpoint facilitate the development of what?

A

Aneuploidy

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14
Q

Human cancer become clinically detectable if the size of primary mass is?

A

1 cm or about 10 to the power of 9 cells

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15
Q

Most human present the cancer of how many tumor?

A

10 to the power of 10 cells

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16
Q

Lethal tumor is about?

A

10^12 to 10^13 cells

17
Q

It is a cellular changes in vitro propagation?

A

DNA polymerase

18
Q

Unable to replicate the tips of chromosome

A

DNA polymerase