Cancer Cell Biology Flashcards
A cancer without invasion of tissue
Benign
It has tissue invasion
Malignant
Cancers that are derived from EPITHELIAL TISSUE are called?
Carcinoma
Cancer that is derived from MESYNCHYMAL tissue is called?
Sarcoma
Those derived from hematopoietic cell is called?
Leukemia, lymphoma and plasma cell dyscrasias
It is a cell Cycle check point that function for growth and preparation for DNA synthesis?
G1
DNA synthesis cell cycle check point
S phase
What pathway is activated when DNA damage is detected
P53 pathway
What is the most frequent mutations in human CA?
P53 MUTATION ON CHROMOSOME 17p
What are the 2 oncogenes of virus
E6 and e7
It acts to INCREASE the rapid turn over of p53
E6
It INHIBITS the Rb function
E7
An abnormality in spindle checkpoint facilitate the development of what?
Aneuploidy
Human cancer become clinically detectable if the size of primary mass is?
1 cm or about 10 to the power of 9 cells
Most human present the cancer of how many tumor?
10 to the power of 10 cells