Cancer Case Studies

Question 1

Chronic Myeloid leukaemia presentation

Answer 1

No clinical symptoms
good health
Splenomegaly (palpable)

Question 2

CML cells of origin

Answer 2

Neutrophil
Eosinophil
Basophil (mast cell)
Platelets

Question 3

CML incidence

Answer 3

1.5 in 100,000 per year

675 new diagnosis UK 2011

Question 4

Tyrosine Kinase Inhibitors (TKIs) 1st generation

Answer 4

Imatinib

Question 5

TKI 2nd generation

Answer 5

Nilotinib

Dasatinib

Question 6

TKI 3rd generation

Answer 6

Ponatinib

Bosutinib

Question 7

CML Treatment algorithm

Answer 7

1st or 2nd generation TKI
If no response, 2nd generation TKI
Then allogeneic stem cell transplant

Question 8

Hodgkins Classification

Answer 8

It is a Lymphoid neoplasm
Hodgkin Lymphoma
Non-Hodgkins Lymphoma (B Cell or T Cell)

Question 9

B Cell non Hodgkins Lymphoma

Answer 9

Aggressive or Indolent
Aggressive- rapid, treat with chemo
Indolent- slow, watch and wait, patient asymptomatic

Question 10

Chemoimmunotherapy- used against Lymphoid neoplasms

Answer 10

Cytostatic drugs + targeted immunotherapy (Rituximab)

Question 11

Thalidomide

Lenalidomide

Answer 11

Anti-proliferative
Co-stimulation of T cells + NK cell activation
Anti-angiogenic

Question 12

Bortezomib

Answer 12

Proteasome inhibitor

Question 13

Temsirolimus

Answer 13

mTOR inhibitor