Cancer associations

Question 1

BCR-ABL

Answer 1

tyrosine kinase

CML, ALL

Question 2

bcl-2

Answer 2

anti-apoptotic molecule (inhibits apoptosis)

follicular and undifferentiated lymphomas

Question 3

BRAF

Answer 3

serine/threonine kinase

melanoma

Question 4

c-kit

Answer 4

cytokine receptor (stem cell factor)

gastrointestinal stromal tumor (GIST)

Question 5

c-myc

Answer 5

transcription factor

Burkitt lymphoma

Question 6

HER2/neu

c-erbB2

Answer 6

tyrosine kinase

breast, ovarian, and gastric carcinomas

Question 7

L-myc

Answer 7

transcription factor

Lung tumor

Question 8

N-myc

Answer 8

transcription factor

Neuroblastoma

Question 9

ras

Answer 9

GTPase

colon cancer, lung cancer, pancreatic cancer

Question 10

ret

Answer 10

Tyrosine kinase

MEN 2A and 2B

Question 11

APC

Answer 11

Colorectal cancer (associated with FAP)

Question 12

BRCA1

Answer 12

DNA repair protein

breast and ovarian cancer

Question 13

BRCA2

Answer 13

DNA repair protein

breast and ovarian cancer

Question 14

CPD4/SMAD4

Answer 14

DPC (Deleted in Pancreatic Cancer)

Pancreatic cancer

Question 15

DCC

Answer 15

DCC (Deleted in Colon Cancer)

Colon cancer

Question 16

MEN1

Answer 16

MEN type 1:

• Pituitary
• Pancreas
• Parathyroid

Question 17

NF1

Answer 17

RAS GTPase activating protein (neurofibromin)

Neurofibromatosis 1

Question 18

NF2

Answer 18

Merlin (schwannomin) protein

Neurofibromatosis 2

Question 19

p16

Answer 19

cyclin-dependent kinase inhibitor 2A

melanoma

Question 20

p53

Answer 20

transcription factor for p21, blocks G1 to S phase

most human cancers
Li-Fraumeni syndrome

Question 21

PTEN

Answer 21

breast, prostate, endometrial cancer

Question 22

Rb

Answer 22

Inhibits E2F; blocks G1 to S phase

Retinoblastoma, osteosarcoma

Question 23

TSC1

Answer 23

hamartin protein

tuberous sclerosis

Question 24

TSC2

Answer 24

tuberin protein

tuberous sclerosis

Question 25

VHL

Answer 25

Inhibits hypoxia inducible factor 1a von Hippel-Lindau disease

Question 26

WT1

Answer 26

Wilms Tumor | nephroblastoma

Question 27

WT2

Answer 27

Wilms Tumor | nephroblastoma

Question 28

Alk phos

Answer 28

bone metastasis Paget disease Seminoma

Question 29

alpha-fetoprotein

Answer 29

``` HCC hepatoblastoma yolk sac tumors testicular cancer mixed germ cell tumor (with HCG) ```

Question 30

beta-hCG

Answer 30

Hydatidiform moles Choriocarcinomas Testicular cancer

Question 31

CA-15-3 | CA-27-29

Answer 31

breast cancer

Question 32

CA-19-9

Answer 32

pancreatic adenocarcinoma

Question 33

CA-125

Answer 33

ovarian cancer

Question 34

calcitonin

Answer 34

medullary thyroid carcinoma

Question 35

CEA

Answer 35

CarcinoEmbryonic Antigen: 70% of colorectal and pancreatic cancers also: breast, gastric, and medullary thyroid carcinomas

Question 36

S-100

Answer 36

neural crest origin: - melanoma - neural tumors - schwannomas - Langerhans cell histiocytosis

Question 37

TRAP

Answer 37

TRAP: Tartate-Resistant Acid Phosphatase Hairy cell (B-cell) leukemia

Question 38

EBV

Answer 38

Burkitt Lymphoma Hodgkin Lymphoma nasopharyngeal cancer CNS lymphoma (immunocompromised pts)

Question 39

Hep B/Hep C

Answer 39

HCC

Question 40

HHV-8

Answer 40

Kaposi sarcoma | body cavity fluid B-cell lymphoma

Question 41

HPV

Answer 41

HPV 16, 18: cervical and penile/anal carcinoma, head/neck/throat cancer

Question 42

H.pylori

Answer 42

Gastric adenocarcinoma | MALT lymphoma

Question 43

HTLV-1

Answer 43

Adult T-cell leukemia/lymphoma

Question 44

Liver fluke | Clonorchis sinensis

Answer 44

Cholangiocarcinoma

Question 45

Schistosoma haematobium

Answer 45

Bladder cancer (squamous cell)