Antidepressants Flashcards
0
Q
SSRI treatments
A
- depression
- OCD
- panic disorders
- anxiety
- eating disorders
1
Q
SSRI drugs
A
- fluoxetine
- paroxetine
- sertraline (also DA reuptake inhibitor)
- citalopram
- venlafaxine
2
Q
General properties of SSRIs
A
block reuptake of serotonin
more specific, less side effects than TCAs
high therapeutic index
taper to prevent withdrawal sx
SEROTONIN SYNDROME: (SSRI+MAOI or fenfleuramine)
3
Q
fluoxetine
A
fluoxetine: Prozac SSRI - inhibits CYP2D6, 3A4 - possible suicide in children - shorter duration, withdrawal sx more likely (dizziness) - akathisia
4
Q
sertraline
A
sertraline: Zoloft
SSRI + DA reuptake inhibitor
5
Q
paroxetine
A
paroxetine: Paxil
SSRI
inhibits CYP2D6
6
Q
SNRIs
A
- venlafaxine
- duloxetine
7
Q
venlafaxine
A
venlafaxine: Effexor
SNRI
-shorter duration, withdrawal sx more likely (dizziness)
8
Q
duloxetine
A
duloxetine: Cymbalta
SNRI
9
Q
Adverse effects of SSRIs
A
- HEADACHE
- GI UPSET, nausea, wt loss
- SEXUAL DYSFUNCTION
- CNS stimulation: anxiety, insomnia, agitation
- akathisia (esp. fluoxetine)
10
Q
Conditions SNRIs can treat
A
- depression
- pain disorders: neuropathies, fibromyalgia
- anxiety
- stress urinary incontinence
11
Q
trazodone
A
trazodone: Desyrel
-weak serotonin reuptake inhibitor
-serotonin receptor antagonist
(some alpha-1, H1 block NO MUSCARINIC BLOCK)
side effects: SEDATION, orthostatic hypotension, nausea, dizziness
