Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Cancer > Cancer as a Disease – Breast Cancer > Flashcards

Cancer as a Disease – Breast Cancer Flashcards

1
Q

What is special about the breast as an organ?

A

It is the only organ that develops after birth

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Where do the vast majority of breast cancers originate?

A

In the luminal epithelium of the breast (> 90%)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Describe the two layers of epithelial cells in the mammary gland.

A

Luminal epithelium

Myoepithelium - contractile cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is found between the tubules?

A

Fatty stromal cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is special about the myoepithelial cells?

A

They have a contractile phenotype

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Where are oestrogen receptors expressed in the breast?

A

They are ONLY expressed by luminal cells

But not all luminal cells express oestrogen receptors (only about 10-15%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Describe the response to oestrogen in a normal breast.

A

The response to oestrogen is to stimulate growth
The cell that express oestrogen receptors do NOT grow in response to oestrogen
They act as a beacon and produce growth factors the stimulate the growth of nearby cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

How is this response different in breast cancer?

A

The cells displaying oestrogen receptors directly respond to oestrogen as a growth factor and stimulate their own growth

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the difference between lobular and medullary carcinoma?

A

Lobular – the tumour has some resemblance of the architecture of the gland (there are tubules of some form)
Medullary – the tumour cells don’t look anything like the epithelial cells from the mammary gland

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What specific type of breast cancer accounts for almost 80% of breast cancers?

A

Infiltrating ductal carcinoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What percentage of breast cancers is ER positive?

A

80%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

State some risk factors for breast cancer.

A 
Early age of onset of menstruation  
Late age to menopause  
Age to first full-time pregnancy  
Some contraceptive pills  
Some HRT
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Where is the oestrogen receptor normally located?

A

It is a cytosolic receptor

It is found in the cytosol bound to a heatshock protein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What happens when oestrogen binds to ER?

A

The oestrogen binds to ER and then two ERs dimerise and translocate to the nucleus (with oestrogen bound)
The dimer then binds to response elements in the DNA sequence and regulates transcription

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are the most important target genes for the ER transcription factor?

A

Progesterone receptor
Cyclin D1
c-myc
TGF-alpha

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Why does high dose therapy with synthetic oestrogens cause breast tumour regression in post-menopausal women with breast cancer?

A

High-dose therapy overstimulates the hormonal system leading to downregulation of ER so the cells are no longer responsive to oestrogen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

How does the presence of ER affect prognosis

A

GOOD prognosis in women

Worse prognosis in male breast cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What are three methods of reducing oestrogen action in the breast?

A

Ovarian suppression
Blocking oestrogen production by enzymatic inhibition
Inhibiting oestrogen responses

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

At what point during the menstrual cycle is oestrogen at its highest?

A

End of the follicular phase

20
Q

How do post-menopausal women make oestrogen?

A

Aromatisation of androgens

21
Q

What are two methods of ovarian ablation?

A

Surgical oophorectomy

Ovarian irradiation

22
Q

What are the problems associated with these methods?

A

They are irreversible

23
Q

Describe a reversible and reliable medical ovarian ablation technique.

A

LHRH agonists bind to LHRH receptors in the pituitary leading to receptor downregulation and suppression of LH release and inhibitionof ovarian function, including oestrogen production

24
Q

Give an example of a LHRH agonist.

A

Goserelin
Buserelin
Triptorelin
Leuprolife

25
Q

Name an important ER receptor blocker.

A

Tamoxifen

26
Q

What is a SERM?

A

Selective oestrogen receptor modulator

27
Q

Why is tamoxifen considered a SERM?

A

It is anti-oestrogenic in the breast

It is oestrogenic in bone and cardiovascular system

28
Q

Name a drug that is a pure anti-oestrogen, showing no oestrogen like activity at all.

A

Faslodex

29
Q

What is raloxifene?

A

A SERM – it is oestrogenic in bone and anti-oestrogenic in the breast and uterus

30
Q

What are the problems associated with tamoxifen?

A

Increased incidence of endometrial cancer (oestrogenic in the uterus)
Increased risk of stroke, DVT, cataracts

31
Q

Which adrenal hormones are aromatised in post-menopausal women?

A

Androstenedione (and testosterone, to a lesser extent)

32
Q

What type of oestrogen is produced in aromatisation?

A

Oestrone

33
Q

What does the aromatase complex consist of?

A

CYP450 heme containing protein

NADPH CYP450 reductase

34
Q

What are the two types of aromatase inhibitor?

A

Suicide inhibitors

Competitive inhibitors

35
Q

How do suicide inhibitors work?

A

They initially compete with the natural substrate for the active site
The enzyme then specifically acts on the inhibitor to yield reactivealkylating species, which form covalent bonds at or near the active site of the enzyme
Through this mechanism the enzyme is irreversibly inactivated

36
Q

Give an example of a suicide inhibitor.

A

Exemestane

37
Q

Give an example of a competitive aromatase inhibitor.

A

Anastrozole

38
Q

What can progestin therapy be used for?

A

Metastatic breast cancer

39
Q

What is the main progestin used for metastatic breast cancer?

A

Megestrol acetate

40
Q

What is a big problem with endocrine therapy?

A

Resistance develops

41
Q

Women in which age range are targeted for breast cancer screening? How often are they asked to go for screening?

A

50-64 yrs (this is being extended to 70 yrs)

Every 3 years

42
Q

What proportion of breast tumours are first spotted by the women themselves?

A

> 90%

43
Q

What is the leading female cancer, and what is the proportion of cancer deaths for this?

A

Breast cancer, 1 in 5.

44
Q

What is the incidence rate for women in the UK and the US for developing breast cancer

A

1 in 8

45
Q

What are some of the reasons for the fall in breast cancer mortality?

A

Early diagnosis, chemo/radio therapies, hormonal therapies

46
Q

How is milk expressed into the luminal space?

A

Myoepithelial cells contract and squeeze the luminal epithelial cells, squeezing the milk globules from the ducts into the luminal space and into the nipple

Cancer (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions