Cancer Flashcards
Cachexia
Anorexia anemia, malaise, fatigue. Eight loss, generalized wasting
What causes sx in cachexia?
tNF alpha cytokine
How does sepsis present?
Warm and well perfused caused by massive vasodilated by lipopolysaccarides (cause what?), hypotension also from vasodilatación not from low volume or volume loss,
Acute phase reactants are made by what?
Liver
These are products made by lover in inflammation or infection.Liver goes into overdrive and makes acute reactantas like
Ceruloplasmin, haptoglobin, amiloid, complement, ferritin
What gene causes resistance to chemotherapy.
MDR1
Chemotherapy resistance is caused by what?
Increased flux of drug out of cytosine, reduces influx to cytosine, self heals itself from chemotherapy, amplify resistance genes, mutations
Tumor lysis syndorme
Emergency during chemotherapy. All tumor cells lose at same time because susceptible to the agent and release all potassium that sits inside of their cells. All of this at once gets hyperKalemia. Also hypocalcemia because calcium binds to all the ohospahate to for, the calcium phospahate salts. Hyoerphospahatemia because all of it ha suene released from the cell so it increases in blood.
Nucleotide release by tumor lysis causes
Uriel acid which damages kidney.
Uriel acid precipitates in an
Acidic environment
Hypocalcemia in tumor lysis syndrome gives you
Calcium stones, tetany, seizure y myopathies.
Rasburicase is used for?
Wash out the Uric acid from the kidney. It is approved by FDA for Tumor lysis Syndrome. Does not work for gout.
Turns uric acid into allantoin whcih then gets excreted.
Number three cancer for everything
Colcorectal
Number one killer of man and women
Lung cancer
Number two killer are
Breast and prostate
Number one cancer incidence is
Breast and prostate
Number two cancer in terms of incidence and prevalence
Lung cancer
Number one cancer over all, everything accounted for
.
Breast cancer, estimated 271,000 new cases for 2019
Number three cancer is
Prostate
Number four cancer across the board
Skin cancer
Metaolasia
One type of cell is replaced with another bc new cell can handle better the new hostile environment.
Squamous epithelial replaced by columnar epithelium is an example of a ——— better examples by barrett’s esophagus.
Metaplasia
Why do we worry about Barrett’s?
Structures which could cause dysphasia.
Carcinoma in situ is example of
High grade dysphasia which does not violate the BM.
High grade dysphasia involves
Entire epithelium that doesn’t penetrate Bm
Description of dysplastic cells
Cells pleomorphic so they vary in shape and size, o sea, cells are diff from each other, the stain intensely bc they are replicating, mitifica cells increases so epithelium does not look normal, nucleares to cytoplasm is elevated bc these cells have very little cytoplasm bc they are replicating their DNA
Metastasis
Violation of BM. Then get into vasculature, etc.
How can cancer cells can hide themselves?
Hide by adhering to platelets.
When tumor cells detach what decreases?
There is decrease in e cadherin
Laminin binds to —— in Bm
Enactin
Metástasis steps
- Cells detach from other cells by decrease e cedhering
- Increase expression of laminin and adhesion molecules to adhere to the BM
- Secrets proteolytic enzymes
What do metalloproreinases do?
They degrade both extracellukar Matrix and BM laminin y type 4 y 7 collagen
First step of invasion?
Penetration of BM
First place of breast cancer to go?
Lymphatic, to LN. From lymphatics can drain into circulation through thoracic duct, or from subcutaneous to small blood vessel.
Breast cancer goes to
Bones, brain liver and lungs
Colon cancer goes to
Liver, lungs, bones, and brain
Prostate goes only to
The bones
Melanoma
Bones, brain liver and lungs