cancer

Question 1

gets converted to active metabolite by liver and causes hemorrhagic cystitis unless given with MESNA

Answer 1

cyclophosphamide

Question 2

causes nephrotoxicity, ototoxicity, and neuropathy at high doses

Answer 2

cisplatin

Question 3

causes cold-induced neuropathy

Answer 3

oxaliplatin

Question 4

active as administered, and used with leucovorin to prevent toxic effects

Answer 4

MTX

Question 5

converted by deoxycytidine kinase to active drug, which terminates DNA synthesis

Answer 5

cytarabine

Question 6

prodrug metabolized by HGPRT to TIMP, which inhibits DNA synth… used to maintain remission in ALL. Interacts with allopurinol

Answer 6

Mercaptopurine

Question 7

Intercalates G-C pairs of DNA. Used in Wilm’s tumors, but causes sever hematopoietic suppression with pancytopenia.

Answer 7

Dactinomycin

Question 8

Intercalates and forms OH radical, which cleaves DNA.

Answer 8

Daunorubicin

Question 9

Less cardiotoxic than other Intercalating agents

Answer 9

mitoxantrone

Question 10

intercalating agent that causes pulmonary toxicity

Answer 10

bleomycin

Question 11

Blocks tubulin polymerization into microtubules

Answer 11

vinblastine

Question 12

blocks microtubule depolymerization into tubulin

Answer 12

paclitaxel

Question 13

blocks tubulin polymerization with relatively low bone marrow toxicity

Answer 13

vincristine

Question 14

Inhibits topoisomerase I

Answer 14

irinotecan

Question 15

Androgen ablation therapy along with AR blockers by inhibiting release of FSH and LH

Answer 15

leuprolide

Question 16

Inhibits abl kinase… first line therapy for CML

Answer 16

imatinib

Question 17

CD20 B cell antibody that causes apoptosis…. for non-hodgkins lymphoma

Answer 17

rituximab

Question 18

HER2/neu receptor antibody

Answer 18

trastuzumab

Question 19

ATRA induces terminal differentiation in malignant immature promyelocytes… used in APL

Answer 19

retinoids

Question 20

Trial phases

Answer 20

I: safety
II: efficacy
III: compare