Cancer Flashcards
term related to a deviation from the
normal functioning anatomy of the generalized cell.
Aberration
Group of disorders characterized by
abnormal - cell growth and the ability to metastasize with
potential in killing the host.
Cellular Aberrations
efers to the group of diseases in which cells
grow and spread unrestrained throughout the body.
CANCER/CA
Process of transformation from normal cell to a
neoplastic cell
CARCINOGENESIS
Occurs when cancer cells infiltrate adjacent tissues
surrounding the neoplasm.
INVASION
Occurs when malignant cells travel through the blood
or lymph and invade other tissues
METASTASIS
s develop specific
structures and function in order to specialize in certain
tasks.
DIFFERENTIATION
four epidemic non-communicable
diseases (NCDs) or lifestyle-related diseases (LRDs) which
include
-cardiovascular diseases,
- diabetes mellitus,
- chronic respiratory diseases.
Refers to a tumor arises from epithelial
tissue, the name of the cancer identifies the location.
CARCINOMA -
tumor arising from supportive
tissue; the name of the cancer identifies the specific tissue
SARCOMA -
malignant disorder of the blood-forming
tissues of the bone marrow, spleen, and lymph system
LEUKEMIA -
group of malignant neoplasm that affects
the lymphatic system resulting in the proliferation of
lymphocytes
LYMPHOMA
characterized by unregulated proliferation of WBCs and their
precursors.
LEUKEMIA
Cancer of the plasma cells
MYELOMA -
- Increase in size of normal cells
*HYPERTROPHY -
- Shrinkage of cell size
ATROPHY -
increase in number of normal cells
*HYPERPLASIA
Conversion from the normal pattern of
differentiation of one type of cells into another type of cell not
normal for that tissue
*METAPLASIA -
Alteration in the shape, size, appearance, and
distribution of cells
*DYSPLASIA -
Disorganized, irregular cells that have no
structure and have lots of differentiation; the result is almost
malignant.
*ANAPLASIA -
Stages of Tumor Progression
HAHMDA
Hypetrophy-Atrophy-Hyperplasia-Metaplasia-Dysplasia-Anaplasia
conceptualizes that normal cells may be transformed into
cancer cells due to exposure to some etiologic agents
Cellular Transformation and Derangement Theory
advocates that all individuals possess cancer cells. However,
the cancer cells are recognized by the immune response
system.
Failure of the Immune Response Theory
2 PATHOGENESIS OF CANCER
Cellular Transformation and Derangement Theory
Failure of the Immune Response Theory
development of a malignant tumor in
otherwise healthy tissue is the result of a complex
series of events beginning with a single cell that has
acquired malignant properties through cellular DNA
damage
CARCINOGENESIS
Steps: of Carcinogenesis
IPLPI
- Imitation
- Promotions
- Latency
- Progression
- Invasion to neighboring organs
Most common and useful staging system for most types of
cancer by
AJCC and UICC
y American Joint Committee on Cancer (AJCC) and
the Union for International Cancer Control (UICC)
TNM?
Tumor
Nodes
Metastasis
no available information on primary tumor
Tx
T0
No evidence of primary tumor
TIS
only carcinoma in situ
T1
<2cm
T2
2-4 cm
> 4 cm tumor
T3
T4
> 4cm, involved natrum, based of tongue
(regional Lymph Node)
N
Nx
- cannot be assessed clinically
● NO - no evidence of regular node met
NO
no evidence of regular node metastasis
N1
Single ipsilateral <3cm
Single ipsilateral 3-6 cm
N2A