Call points and products for each Flashcards
Industry (Biopharma and Biotech)
you would call on industry when a company is developing new treatments or drugs and needs to conduct large-scale genomic analysis, targeted sequencing or genetic variant identification to inform their research or clinical trials.
common twist products for industry
- Twist targeted panels (specific gene panels for oncology, immunology, etc)
- Twist Custom panels (for tailoring sequences to a particular project)
case example for usage with industry leaders
a biopharma company is working on a new cancer drug, they need to understand genetic mutations in certain genes (KRAS EGFR) in cancer patients to determine if their drug could target those mutations. They would use the Twist targeted panels for oncology to sequence and analyze these specific genes in the patients DNA. Twist panels would allow them to only focus on the genes of interest and save time/money.
CRO’s (contract research organizations)
You would call on CRO’s when they’re hired by companies to perform the genomic analysis for clinical trials or research projects. CRO’s are hired to conduct experiments and generate data on behalf of pharma companies, biotech firms or academic institutions.
common twist products used for CRO’s
- Targeted panels (for clinical research or trials)
- Custom panels ( for specific, custom sequencing projects)
- Whole exome panels (for broad genetic analysis)
case example for usage with CRO’s
A CRO is tasked with helping a pharma company run a clinical trial for a new treatment aimed at a rare disease. The trial participants have specific genetic mutations that need to be identified to evaluate how the treatment responds to these genetic changes. The CRO uses Twist custom panels to design a panel tailored to the specific genes of interest, allowing them to identify rare variants efficiently.
Analogy
Think of this like a custom tailored suit- The CRO can design a sequence panel to match exactly what the pharma company is studying, rather than using a generic, one-size fits all option.
Academic medical centers
you should call on AMC’s when researchers, doctors, or medical scientists are conducting basic research, clinical diagnostics, or gene therapy studies. These centers typically explore a broad range of genetic diseases, from cancer to rare genetic conditions.
common panels used with AMC’s
- twist targeted panels (cancer research, neurological diseases)
- Whole exome panels (for broader studies like identifying rare genetic diseases)
- Twist custom panels (for highly specialized or rare disease)
case example for AMC’s
in a university-affiliated medical center, a research team is studying a rare genetic disorder and needs to sequence the genomes of a group of patients. Instead of sequencing the entire genome (which would be more expensive) they use Twist whole exome panels to focus on the coding regions of the genome (where more disease-causing mutations) happen. This helps them identify which specific mutations could be causing the disorder.
Analogy
this is like looking for a specific piece of a puzzle. Instead of trying to find every piece in a giant pile, by focusing on the most relevant parts (the exomes) they save reseources and still get valuable data.
Summary of products by institution
Industry (biopharma)
Twist targeted panels
Twist custom panels
- cancer research focused. identifying mutations in genes like KRAS, EGFR to inform drug development
CRO’s
Twist targeted panels
Twist custom panels
Twist whole exome panels
*clinical trials, identifying rare genetic mutations in patients to study drug responses in a clinical setting.
AMC’s
Twist targeted panels
Twist custom panels
Twist whole exome panels
*Genetic disorder research, focusing on specific genes or exomes to identify mutations linked to diseases.
