Caffeine W10 Flashcards
Where is caffeine metabolised?
The liver
What is caffeine?
1,3,7-trimthylxanthine
When do peak blood caffeine concentration occur?
Typically occurs 60min after ingestion in a dose-dependent way
What are the effects of caffeine?
Improved vigilance and alertness
Reduced perception of effort
Reduced fatigue and pain
What is the number 1 mechanism of caffeine? (Central Effect)
When adenosine binds to its receptor, this causes fatigue. Caffeine prevents adenosine binding and thereby delays fatigue
What is the number 2 mechanism of caffeine? (Metabolic effect)
Caffeine stimulates lipolysis (breakdown of triglycerides), directly and via an increase in adrenaline. This may spare muscle glycogen
What is the number 3 mechanism of caffeine? (Muscle ion effect)
Caffeine stimulates calcium release which is important for muscle contraction
How does caffeine increase calcium release in muscle?
Caffeine increases the release of intramuscular calcium ions (Ca2+), responsible for muscle contractions, although this seems to happen with very high doses of caffeine
How does caffeine increase fat metabolism and oxidation?
Caffeine can directly (increase triglycerides breakdown) or indirectly (increase epinephrine)
Does caffeine and carbohydrate co-ingestion work in influencing substrate metabolism?
No- there is no effect on substrate metabolism
How does caffeine block adenosine?
The MAIN MECHANISM
Caffeine has similar chemical structure to a molecule called adenosine (responsible for feelings of tiredness, fatigue and even pain sensation)
Therefore, caffeine can stop adenosine from binding to its receptors in the brain, reducing the sensations of both tiredness and pain
What is an advantage of using caffeinated gum?
Most of the caffeine bypasses the gut
- increases absorption
- decreases GI distress
What is the optimal dose of caffeine to enhance athletic performance?
3mg/kg BM
When should you consume caffeine to enhance performance?
40-60min prior
How much caffeine should you ingest doing exercise?
1.5mg/kg