CAD 2 Flashcards by Zoya Kosmodemyanskaya | Brainscape

Q

Clopidogrel use

A

Acute MI
Aspirin intolerance
Recent angioplasty with stenting

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Q

Clopidogrel side effect

A

Thrombotic thrombocytopenic purpura

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Q

Ticlopedine side effect

A

Neutropenia

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Q

Prasugrel (antiplatelet med) use in

A

Angioplasty & stenting
All acute MI
intolerant of aspirin

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Q

Prasugrel SE

A

> 75 increased hemorrhagic stroke

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Q

ACE inh. use

A

low EF/systolic dysfunction

* regurgitant valvular disease

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Q

Statins ( HMG-CoA reductase inhibitors) CAD with

A

LDL> 100 mg/dl

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Q

CAD+ DM treat with statins when

A

LDL>70

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Q

CAD equivalents(LDL>100= statins)

A

PAD. • DM
Carotid disease
Aortic atherosclerosis

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Q

Most common SE of statins

A

Liver dysfunction => check AST/ALT

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Q

Why statins improve mortality

A

Antioxidant effect on endothelial lining of CA

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Q

Niacin SE

A

Glucose intolerance
elev. of uric acid
itchiness( histamine)

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Q

Niacin increase HDL, add to statins if

A

statins not control enough LDL

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Q

Fibric acid derivative

A

Gemfibrozil

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Q

Caution when use fibrates+ statins

A

Increased myositis

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Q

Cholestyramine ( bile acid sequestrant) SE

A

Constipation & flatus, abd cramping

* interactions with med in gut

Q

Ezetimibe use if statin doesn’t work

A

No benefit on mortality( MI, stroke)

Q

Lower mortality the most

A

Statins

Q

Myositis SE of

A

Statins

Q

May increase mortality with CAD( inc HR)

A

Calcium channel blockers

Q

CCB use ( verapamil, diltiazem DO NOT inr. HR)

A

Asthma ( can’t use bblockers)

Q

Cocaine induced chest pain

* prinzmetal

A

CCB ( v/d)

Q

SE of CCB

A

Edema • Constipation

* Heart block

Q

CABG

A

3 vessels with > 70 % stenosis each
L main
2v+ DM

Q

CABG Internal mammary grafts lasts

A

10 years

Q

CABG saphenous vein grafts lasts

A

5 years

Q

Percutaneous coronary intervention PCI= angioplasty best in

A

ACS with ST segment elevation

Q

PCI does NOT provide mortality benefit for stable pts

A

Better medications( asp, bb, ACE, statins)